<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05945

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMSVSLSDFEAKVKNLFKEHAKSGIAHFFFRPYLITSSEEYEKEIVISTANELMEIFTSLPQNLQESAFSIVISHRVLSNSANKIVDFFVRNVIQRQMLSIKCICEKLLTCAELNINSCGWNDTFAFFMENISLLDYKGVRDTLKRLLDIPIPVHLQVDQRKSVEAVEKLIKTICDRKNNLLPAYFVITEIIKNLPEQRCFSHWRMADCFTEIIESFRPLAQLNSVCGRTFMTPIPGHVGFYFNAFWKLEALSLRFPLKGLLPYSQDLLNPQMRLLTHVFMHYTYRDAIAVLLGTAKPEKSRIPYFEEVITEIILELMFTAECDHSQLNPQAWRIISTQIIYLTLQQSICFTRLVKILHTKLTHYPYRYARNQLMWCLFNFLSGGMQKYSVEEFAVILDLYRLLYTGRDIFTVSGSDSSCVLMLAPTCIWIHILKKSPSMEVELPPTVNTQRKFLQEALKNKTQFNTDNYMVAVLCNAYSSTSEIFQQDLLPILLENLDNTRGHNSTQASGNFASNTTSSMPYPNGAVSEVKLRPLKLEFLDSVSVHVRMNIANSLIGTFGRFMQGKSAWPSPALVETYCRMLTYPDLEILGLKQFTSHIVLTAARHQCCEMMYICCEILNYRLFNIPSTYRVHAIVTLQQTLAFAKFQTNASLYWMLERTLLLQFQWYPHYEIFQAPFARLLNSFVAVAADGTKQSIAENEELMRIIILTLARSTVISSNSDSCFIEGVYRELLNKLPSYSWPQSTLSVFPQVFCSHYTQQQQQQQQQQQQQQQQQQQQQPQQPQQQQQQQQPQPQQSNVVVGSSQQPQQQQQSRFLLKQQVDEEYIKHRTFGSELSLIDYFTNTSTSTVYLCLLWRLVYDTGELPAVSMKILEVLGPRKVLVHLKSLADFLVYETNSADVNRCVDVLNRLIFKYAVVPLERFMLTMLLRDYEGNDAFYALLIVMLLVQRSEELRSAVADCVAMLPSDYWHCQDWNDKYQAYQIKHAERTWSQVYVELSRASLTPNDCPLPVYFGTRCLQMLPVVDLLLQKLVESPAACLKFLDSTLSILGPLYRFHPYPVSFLYSTFRFYEKRLVESPAIKQKLALAVHGACVPSRDDHWLLSAEFVGWVGQATDRGPWVPDLNYYGALVRRLIDTFSEPRQQWSRKTDLRFVEFNNFQTHALYSICIELMSLPVGVVDVGNALVTLVTHWHSLVDKNTVMYWVNAIGLIFSALPISYMEPFYQTILTTLCSDNMNSINTDVSNKLDFEKRSKLMEDCYPARILALCHAVWLHSTSGYLQLLPQALRSTWIPHVRSEGQFLYVCHLVAPFLQRFYQERTKFTMDITTDLYQMLYNVDCEVGNWKYEDLICDFFYHVKYMYVGDSVRQDTDRIIPMLRPSLQQKLRYISFAQGEQSAGTPFSEMINPIKLLGIQMVVWLQRLPIFGETAQHFWLAVTKLGDPVMTFSLYFPALFPFFGTAALDMVIVGAFSEISNCILKWILLDDRPYWWVHTAGVSGQLSHPLKQFQWTCETGPGSPSGHAMVSASVWFNLLYNLQSDLVLGDLCGICWLLYVVFLIAVSISRTYISAHFPDQVILGIVVGICIALVTRSLVGHRRRRWSNLIAFMIALLLIALSVHEVHRFFGVDTHRSIELAAKYCHRAEWIHQSTTPLASFFRDVGVLISVAILLANKSVFTNNNKIASKFFSTKFAQALLGVSLNQFVAFIPIGRLPTALFYGMLFVEHFFCFFTTAVLLPVLFTNNSNKLQ
Length1747
PositionTail
OrganismTrichinella murrelli
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.12
Grand average of hydropathy0.069
Instability index46.18
Isoelectric point7.62
Molecular weight200910.57
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05945
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.47|      16|      16|     760|     775|       1
---------------------------------------------------------------------------
  760-  775 (35.39/18.16)	QQQQQ........QQQQQQQQ.....QQQ
  777-  792 (36.59/18.99)	QQQQP........QQPQQQQQ.....QQQ
  793-  821 (22.49/ 9.25)	PQPQQsnvvvgssQQPQQQQQsrfllKQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     155.41|      47|      81|     918|     967|       2
---------------------------------------------------------------------------
  918-  967 (77.00/52.17)	VPLERFMLT...MLLRDYEGNDAFYALLIVMLLVQRseeLRSAVADCVAMLPS
  996- 1045 (78.41/46.25)	VELSRASLTpndCPLPVYFGTRCLQMLPVVDLLLQK...LVESPAACLKFLDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     293.53|      64|      81|    1563|    1626|       3
---------------------------------------------------------------------------
 1449- 1511 (78.09/52.63)	...YFPALFPffgtaalDMVIVGAFSEISNCILKWILLDDRPYWWVH.....TAGVSGQLS.HPLKQFqWTC
 1531- 1559 (27.00/12.41)	NLLY...NLQ.......SDLVLGDLCGICWLLYVVFLIA.................................
 1563- 1626 (102.52/71.86)	SRTYISAHFP.......DQVILGIVVGICIALVTRSLVGHRRRRWSNLIAFMIALLLIALSVHEVHRF.FGV
 1648- 1708 (85.91/58.79)	STTPLASFFR.......D...VGVLISVAILLANKSVFTNNNKIASKFFSTKFAQALLGVSLNQFVAF.IPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.72|      15|      81|     273|     287|       4
---------------------------------------------------------------------------
  273-  287 (28.85/20.34)	RLLTHVFMHYTYRDA
  355-  369 (28.86/20.35)	KILHTKLTHYPYRYA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     171.89|      43|      82|     112|     154|       5
---------------------------------------------------------------------------
   82-  110 (31.80/13.59)	.............NKIVDFFVRNVIQRQMLSIKCICEKLLTC.....
  112-  154 (74.91/41.30)	ELNINSC..GW..NDTFAFFMENISLLDYKGVRDTLKRLLDIPIPVH
  193-  237 (65.19/35.05)	NLPEQRCfsHWrmADCFTEIIE..SFRPLAQLNSVCGRTFMTPIPGH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     223.34|      46|      85|     545|     590|       6
---------------------------------------------------------------------------
  510-  543 (40.05/26.21)	............GNFASNTTSSM.PYPNGAVSEVKLRPLK.LEFLDSV
  545-  590 (77.83/60.01)	VHVRMNIANSLIGTFGRFMQGKS.AWPSPALVETYCRMLT.YPDLEIL
  592-  626 (49.68/34.83)	LK...QFTSHIVLTAARH........QCCEMMYICCEILN.YRLFNI.
  632-  674 (55.77/40.27)	VHAIVTLQQTL..AFAKFQTNASlYW...MLERTLLLQFQwYPHYEIF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     129.68|      31|      81|    1292|    1322|       7
---------------------------------------------------------------------------
 1265- 1296 (27.55/10.93)	......L.A..LC........HAVwlhstSGYLQLLP............QAlRSTWIPHVR
 1297- 1327 (55.23/28.90)	SEG.QFL.Y..VC........HLV.....APFLQRFY............QE.RTKFTMDIT
 1328- 1378 (24.17/ 8.73)	TDLyQML.YnvDCevgnwkyeDLI.....CDF...FYhvkymyvgdsvrQD.TDRIIPMLR
 1380- 1401 (22.73/ 7.80)	SLQ.QKLrY..I..................SFAQGEQ............SA.GTPF.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.84|      22|      82|    1120|    1144|       8
---------------------------------------------------------------------------
 1120- 1141 (40.59/33.77)	WVPDLNYYG.......ALVRRLIDTFSEP
 1147- 1175 (31.24/15.37)	RKTDLRFVEfnnfqthALYSICIELMSLP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05945 with Med23 domain of Kingdom Metazoa
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