<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05944

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMSVSLSDFEAKVKNLFKEHAKSGIAHFFFRPYLITSSEEYEKEIVISTANELMEIFTSLPQNLQESAFSIVISHRVLSNSANKIVDFFVRNVIQRQMLSIKCICEKLLTCAELNINSCGWNDTFAFFMENISLLDYKGVRDTLKRLLDIPIPVHLQVDQRKSVEAVEKRMADCFTEIIESFRPLAQLNSVCGRTFMTPIPGHVGFYFNAFWKLEALSLRFPLKGLLPYSQDLLNPQMRLLTHVFMHYTYRDAIAVLLGTAKPEKSRIPYFEEVITEIILELMFTAECDHSQLNPQAWRIISTQIIYLTLQQSICFTRLVKILHTKLTHYPYRYARNQLMWCLFNFLSGGMQKYSVEEFAVILDLYRLLYTGRDIFTVSGSDSSCVLMLAPTCIWIHILKKSPSMEVELPPTVNTQRKFLQEALKNKTQFNTDNYMVAVLCNAYSSTSEIFQQDLLPILLENLDNTRGHNSTQASGNFASNTTSSMPYPNGAVSEVKLRPLKLEFLDSVSVHVRMNIANSLIGTFGRFMQGKSAWPSPALVETYCRMLTYPDLEILGLKQFTSHIVLTAARHQCCEMMYICCEILNYRLFNIPSTYRVHAIVTLQQTLAFAKFQTNASLYWMYRYYYYYYYFAPFARLLNSFVAVAADGTKQSIAENEELMRIIILTLARSTVISNSDSCFIEGVYRELLNKLPSYSWPQSTLSVFPQVFCSHYTQQQQQQQQQQQQQQQQQQQQQPQQPQQQQQQQQPQPQQSNVVVGSSQQPQQQQQSRFLLKQQVDEEYIKHRTFGSELSLIDYFTNTSTSTVYLCLLWRLVYDTGELPAVSMKILEVLGPRKVLVHLKSLADFLVYETNSADVNRCVDVLNRLIFKYAVVPLERFMLTMLLRDYEGNDAFYALLIVMLLVQRSEELRSAVADCVAMLPSDYWHCQDWNDKYQAYQIKHAERTWSQVYVELSRASLTPNDCPLPVYFGTRCLQMLPVVDLLLQKLVESPAACLKFLDSTLSILGPLYRFHPYPVSFLYSTFRFYEKRLVESPAIKQKLALAVHGACVPSRDDHWLLSAEFVGWVGQATDRGPWVPDLNYYGALVRRLIDTFSEPRQQWSRKTDLRFVEFNNFQTHALYSICIELMSLPVGVVDVGNALVTLVTHWHSLVDKNTVMYWVNAIGLIFSALPISYMEPFYQTILTTLCSDNMNSINTDVSNKLDFEKRSKLMEDCYPARILALCHAVWLHSTSGYLQLLPQALRSTWIPHVRSEGQFLYVCHLVAPFLQRFYQERTKFTMDITTDLYQMLYNVDCEVGNWKYEDLICDFFYHVKYMYVGDSVRQDTDRIIPMLRPSLQQKLRYISFAQGEQSAGTPFSEMINPIKLLGIQMVVWLQRLPIFGETAQHFWLAVTKLGDPVMTFSLYFPALFPFFGTAALDMVIVGAFSEISNCILKWILLDDRPYWWVHTAGVSGQLSHPLKQFQWTCETGPGSPSGHAMVSASVWFNLLYNLQSDLVLGDLCGICWLLYVVFLIAVSISRTYISAHFPDQVILGIVVGICIALVTRSLVGHRRRRWSNLIAFMIALLLIALSVHEVHRFFGVDTHRSIELAAKYCHRAEWIHQSTTPLASFFRDVGVLISVAILLANKSVFTNNNKIASKFFSTKFAQALLGVSLNQFVAFIPIGRLPTALFYGMLFVEHFFCFFTTAVLLPVLFTNNSNKLQ
Length1702
PositionTail
OrganismTrichinella murrelli
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.12
Grand average of hydropathy0.068
Instability index46.41
Isoelectric point7.62
Molecular weight195725.44
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05944
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.47|      16|      16|     715|     730|       1
---------------------------------------------------------------------------
  715-  730 (35.39/18.78)	QQQQQ........QQQQQQQQ.....QQQ
  732-  747 (36.59/19.63)	QQQQP........QQPQQQQQ.....QQQ
  748-  776 (22.49/ 9.66)	PQPQQsnvvvgssQQPQQQQQsrfllKQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.16|      29|      34|    1207|    1240|       2
---------------------------------------------------------------------------
 1207- 1240 (46.67/33.32)	RSKLMEDCYP.ARILALCHAVwlhstSGYLQLLPQ
 1243- 1272 (51.49/25.60)	RSTWIPHVRSeGQFLYVCHLV.....APFLQRFYQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     119.12|      37|      40|     956|     992|       3
---------------------------------------------------------------------------
  948-  965 (19.71/ 7.89)	.....................QVYVELSRASLTPNDCPL
  966- 1002 (65.92/48.05)	PVY.FGTRCLQML.PVVDLLLQKLVESPAACLKFLDSTL
 1007- 1035 (33.49/19.87)	PLYrFHPYPVSFLySTFRFYEKRLVESPA..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.39|      14|      33|    1494|    1507|       4
---------------------------------------------------------------------------
 1494- 1507 (28.00/15.73)	DLVLGDLCGICWLL
 1529- 1542 (24.39/12.82)	QVILGIVVGICIAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.16|      22|      83|     124|     147|       5
---------------------------------------------------------------------------
   87-  108 (37.90/20.46)	FFVRNVIQRQMLSIKCICEKLL
  126-  147 (36.26/20.19)	FFMENISLLDYKGVRDTLKRLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     196.81|      60|     283|    1345|    1417|       6
---------------------------------------------------------------------------
 1345- 1417 (90.07/77.49)	FAQGEQSAGTPFSEMINPiKLLGIQMVVWLQRLPIfGETAQHFWLAvtklgdpvMTFSLYFpalFPFFGTAAL
 1630- 1689 (106.74/59.41)	FTNNNKIASKFFSTKFAQ.ALLGVSLNQFVAFIPI.GRLPTALFYG........MLFVEHF...FCFFTTAVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.72|      15|      86|     238|     252|       7
---------------------------------------------------------------------------
  238-  252 (28.85/17.64)	RLLTHVFMHYTYRDA
  320-  334 (28.86/17.65)	KILHTKLTHYPYRYA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.84|      22|      83|    1075|    1099|       8
---------------------------------------------------------------------------
 1075- 1096 (40.59/34.84)	WVPDLNYYG.......ALVRRLIDTFSEP
 1102- 1130 (31.24/15.81)	RKTDLRFVEfnnfqthALYSICIELMSLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.19|      25|      33|    1568|    1592|       9
---------------------------------------------------------------------------
 1568- 1592 (43.34/29.39)	IALSVHEVHRFF...GVDTHRSIELAAK
 1600- 1627 (36.84/23.80)	IHQSTTPLASFFrdvGVLISVAILLANK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.10|      23|     283|    1146|    1205|      13
---------------------------------------------------------------------------
  210-  233 (37.54/ 6.67)	FWkLEALSLRF...PLKGLLPYSQDLL
 1158- 1183 (39.55/52.30)	YW.VNAIGLIFsalPISYMEPFYQTIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.15|      11|      34|     544|     554|      17
---------------------------------------------------------------------------
  544-  554 (21.43/13.14)	CRMLTYPDLEI
  581-  591 (20.72/12.44)	CEILNYRLFNI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05944 with Med23 domain of Kingdom Metazoa
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