<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05941

Description Mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMASCTVAWEKKPLKRPRLGQPDVYPQDPKQSEANYNDRFISSNFINDELTAEKVRQGFIYKPPLLNEYESLRSQRFDENLEDYFIKLTQSYNAIVNKKAEINALQDSYKKKSGFKEPSIWHFFIAPLAAKPKGQDTWFKDLSGNKPLSALGKRFPFLNKKDEILYTLAEFNVPMVRVVWFLKMTNAHIAQQQECGKMKKKHMSDPFADWTHLVMKYLRDLCSKLGEFFSLNLEVPMNSEFECHYRHWQYTTKLTRHLFEEGLLDKEMLLNGLLDIFAEKIYASSFGILKMLVPVLLQFIDGFVMSVLLSRRLVYLACKVLSAMKIDNLQNNSENMKEEDEEEEGTLDYLNCPFHRTVLFGLSNVIHAVLIDCPTALIWNEMECEDTGENGKAYLCGSPLDLLYCSPVDLPLFMDPSTEFLCFYCCKKKVKKELERLTEMVAERSRAVESHWSYNKCQHSGLSESTIIQHFLSILDCLDKFKFEYVNETNNIDTLYKTIFQSEKKEMRVDVDSIAVQFLCHWAVSPHRYGSYRAAVVTRLFERHLQEVKHDEFQLSKKMPQVRHPFQKSLFNYLHNQAPNLGEMCSSSEIKPFTNLILLFSRLIESDIFSHDQYVSTLVSSGDLIPNGANIFYPLQNQCSSAAVENVSNTQPAVLMSSNFFSEQFKPIEVSNVDFNYFKDSDESKFDFDRIIDFADKKAMSSDTDSCSSKRVPKLSKHYFNVLHFPVPQDDQYRHECNQRQLLLFGSNSDQYSRKHILKKVYEREGKNVSCVMQIDPDLTKELNKLWSKKTSAELTTTGLIRVRKIIDSESLCSLSRKIQNLVFYDQFAVMDCCCDAGIAQFNSFISGQSNCLPTLENFDFLLGLLEESSNFISLVEFVEAIICLLPKLEAQIVERNFQCANSLTLQYAVCMVGYMRKHHCYFIQLESVMCNIWRSLLLYVKSKTVVNSFSAERCVWVYLHDLYQCCSYIRSLHADLYLNSRDCIQRCLCVETKPSCCNDLRTLLADVSQDIMLDVLFQESDLVIEPNLIQRLVENANLCYAFAIVAVKALCGLSGDTERLFNLVLFCADVTALCPNLNADWLAVFKILCCPFNSSQDQSSCDSLLNIDVSDHQCYQPLTVLVITLISRMCIRLEDFILHVAMPSLLPLWKHAGSAKVEKGSEASAKLTLHLLGKILLFFDYQGPKNALPAKTKGELSLICSSVDGMVPDAILTLLIAILMLDDSKVQELKSKENFDSKRSAAKQFVEEDTNTAGNSDIGSTAIQLLELICRQEWTKRKFLHSTDLFDPKRLLNPLVNQTQAQRLLRMITRSDSEILLKKFDSCTTKKELISKVLDSLTIMNLWVSQMDLQLLLKQVANSQSESLHLVDTIAKSCMEVFQPQATLAFGEPSDDKDENAYLNASSFDEIAPYWLVAPLISRLPSFVQGRVLKAAVSILENCQARRDRNLFVQSSSLLAHQPFLSLVLICLRGQDDQREGLLSSLLKQIQEFVMRVKEDPYILCDRDIVSEMLDALQLRLSLIGGMFDTVCRNANLENWSLVMVQLLLYGIVTEEKNQALFYTCVDILCVLLLSCLLPDSAGFSFSGQERTNEDCKRIYNNVIKKLKVKEIGDRQVPSLRCVHQLLPIPRQMVDIIVCDEYGSQPQKGSRGGFSSSEVTQRKGLQIIGKEKLNPWEIIEGYNRENIGLKWSWFQGIRLDYQPETLFEQMMRMLPHDHHHAFNRPPMPGEPRSDPFLETLQVHYLPCTNETSDSDKLTTERLKSNGPVAISGGTLVSEFSDQVQSPRTTKARARKSTRGRKTSSRVTVSSNVALSSVPPMVQNRQLGIGQPTLTAHYGYYPQQVAMTGGPSGAVPPYGQGQMWSIGNVQSASTAVPPTQYQSRNFTGAQMTPVQSSSGKQAISAMIRGRRPSGSGGQQMMTTAHIQAAPLATGQPYHQQQLHSIGQVDPMVAPMHQVQMQMDARQQLMQESMMEQQQIRTPGPRSMATQQHCLPQVNSAASQPVMHGNYSNYPGQHGGGRMQMTSGRNQYAAQQPAQPPFNCSPNYNAQFYQAQNAGQMRMSQTDVIGQSNVRYTQQPNAIGSSYQMQSQQTLRAPAGYVAQQANPMYAAPNTPQYQAAQQQNVSMYPVSRMSQYSSNVPGQEMNASQQQINYYPPQY
Length2154
PositionKinase
OrganismTrichinella murrelli
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.09
Grand average of hydropathy-0.280
Instability index48.34
Isoelectric point6.55
Molecular weight244465.53
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05941
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     186.89|      26|      67|    2026|    2051|       1
---------------------------------------------------------------------------
 1995- 2017 (33.80/14.08)	.AASQPVMHG.NY..S.NYPGQHGGGRM
 2026- 2051 (52.72/25.99)	YAAQQPAQPPFNC..SPNYNAQFYQAQN
 2062- 2085 (33.97/14.19)	VIGQSNVR..YTQ..QPNAIGSSYQMQS
 2095- 2119 (34.88/14.76)	YVAQQ.ANPMYAApnTPQYQAA..QQQN
 2131- 2153 (31.51/12.64)	YSSNVPGQE.MNA..S.QQQINYYPPQ.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.47|      19|      42|    1764|    1785|       2
---------------------------------------------------------------------------
 1746- 1773 (23.63/11.31)	ETSD...SDKLT.......terlksngpVAISGGTLVS
 1774- 1811 (14.84/12.81)	EFSDqvqSPRTTkararkstrgrktssrVTVSSNVALS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     223.52|      61|      86|     599|     667|       4
---------------------------------------------------------------------------
  538-  592 (76.62/42.54)	..RLFERHLqeVKHDEF....QLSKK...MP...QVRHPFQ....KSLFNYLH.....................NQAPNLgEMCS...SSEI..KPF
  599-  667 (91.89/73.06)	FSRLIESDI..FSHDQYVS..TLVSSgdlIPngaNIFYPLQNQCSSAAVENVS.....................NTQPAV.LMSSNffSEQF..KPI
  687-  756 (55.02/28.40)	FDRIID.....FADKKAMSsdT...................DSCSSKRVPKLSkhyfnvlhfpvpqddqyrhecNQRQLL.LFGSN..SDQYsrKHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.90|      40|      86|    1409|    1461|       5
---------------------------------------------------------------------------
 1409- 1458 (47.63/53.89)	PYWLVAPLISRLPSFVQgRVlKAAVSILenCqarrDRNlfVQSSSLLAHQ
 1475- 1514 (68.27/33.31)	REGLLSSLLKQIQEFVM.RV.KEDPYIL..C....DRD..IVSEMLDALQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     165.25|      53|      67|    1562|    1617|       6
---------------------------------------------------------------------------
 1562- 1617 (83.72/56.57)	VDIL.CVLLLSCLLPDSAGfSFSGQERTNEDCKRIYNNviKKLKVKEI..G.DRQVPSLR
 1630- 1686 (81.53/45.64)	VDIIvCDEYGSQPQKGSRG.GFSSSEVTQRKGLQIIGK..EKLNPWEIieGyNRENIGLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     107.65|      20|      69|     918|     937|       7
---------------------------------------------------------------------------
  918-  937 (37.97/21.40)	HHCYFIQLESVM..CNIWRSLL
  952-  973 (33.10/17.66)	ERCVWVYLHDLYqcCSYIRSLH
  985- 1004 (36.58/20.34)	QRCLCVETKPSC..CNDLRTLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     152.59|      32|      36|    1813|    1844|       8
---------------------------------------------------------------------------
 1813- 1837 (41.23/21.89)	............VPPM.VQNRQLGIG..QPTLTAH.YGYYP
 1838- 1876 (45.55/24.98)	QQVAMTGgpsgaVPPY.GQGQMWSIGnvQSASTAV.PPTQY
 1877- 1907 (35.62/17.88)	QSRNFTG...aqMTP..VQSSS...G..KQAISAMiRGRRP
 1913- 1934 (30.20/14.00)	QQMMTTA.........hIQAAPLATG..QP........YHQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     161.36|      42|      48|    1275|    1316|       9
---------------------------------------------------------------------------
 1229- 1273 (29.96/16.85)	.....LKSKENFDSKRsaakqfveedtntAGNSDIGSTAIQ.LLELICRQE....
 1275- 1316 (70.60/51.37)	TKRKFLHSTDLFDPKR.............LLNPLVNQTQAQRLLRMITRSDSEIL
 1325- 1364 (60.80/43.04)	TKKELI..SKVLDSLT.............IMNLWVSQMDLQLLLKQVANSQSESL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.63|      22|      70|    1059|    1081|      10
---------------------------------------------------------------------------
 1059- 1081 (36.55/26.03)	RLFNLVLFC.....ADVTAlCPNL.NADW
 1083- 1109 (24.79/11.73)	AVFK.ILCCpfnssQDQSS.CDSLlNIDV
 1132- 1149 (29.29/15.37)	RLEDFILHV.....A.....MPSL.LPLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.83|      19|      70|     378|     404|      11
---------------------------------------------------------------------------
  333-  351 (35.63/10.13)	ENMKEEDEEEEG.......TLDYLNC
  379-  404 (31.19/25.33)	NEMECEDTGENGkaylcgsPLDLLYC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     171.43|      50|      76|      26|      76|      13
---------------------------------------------------------------------------
   26-   76 (81.85/55.63)	QDPKQSEANYNDRFISSNFINdELTAEKVRQGFIYKPPLLNEYESLRSQRF
  105-  154 (89.58/56.59)	QDSYKKKSGFKEPSIWHFFIA.PLAAKPKGQDTWFKDLSGNKPLSALGKRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.43|      13|      15|     834|     847|      14
---------------------------------------------------------------------------
  834-  847 (19.98/17.39)	CDAGIAQFNsFISG
  851-  863 (24.45/15.82)	CLPTLENFD.FLLG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05941 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GTLVSEFSDQVQSPRTTKARARKSTRGRKTSSRVTVSSNVALSSVPPMVQNRQLGI
2) IGNVQSASTAVPPTQYQSRNFTGAQMTPVQSSSGKQAISAMIRGRRPSGSGGQQMMTTAHIQAAPLATGQPYHQQQLHSIGQVDPMVAPMHQVQMQMDARQQLMQESMMEQQQIRTPGPRSMATQQHCLPQVNSAASQPVMHGNYSNYPGQHGGGRMQMTSGRNQYAAQQPAQPP
3) RMLPHDHHHAFNRPPMPGEPRSDPFLETLQ
1769
1861
1708
1824
2035
1737










Molecular Recognition Features






MoRF SequenceStartStop




1) LKRPRLG
2) MASCTVAWEKK
3) YYPPQY
13
1
2149
19
11
2154