<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05938

Description Mediator of RNA polymerase II transcription subunit 15 (Fragment)
SequenceLQLFFLYFLSLIMEDDWRSQRQREKVIQHLDNVIRSCTVPLNIPGDARQVENAIFLKANNQEEYMQFVSKIIYHASSGAAAMSQPQRHQAPVNQVPYGNMQPGTQFRRADMRPMQQPIQQQQQQQQQQQQQQVPGQIYSGMRAPPNAEMQPRLLRPMHQPSVTMHHMHQQQAQMGQMGMTQSAGIAAAAQQQPQNVVMLLTSGNPPRQAASAPSAVQLRQPNDIQQFLQQLPPAIRQQILQLPPEEQAEQLKKFFESRRWQQQQQLHQQQQIQQQQQQQQQQQQQQQQIQQQIQHQQQQQQQLQVQQQIQHQMHHVPQNQMHTQAVIQQQQQQQQQQQQQQQQHQQQFASVRQQQQMQMLQPMMQQPGAVRFADQSTTMLYSRPPATPVMIPQTPAPVQQPPSQPAPVTPMSGQAASPNVNIGTPYPSSSPAGAHMMGPSPAYAAETSPVCHPAATPGPKTSQMSPAANSLPPESIGAEHSPYKEKVNELLVYLEPLKRLIEQTKESTSDSSQTQKFQRMVDILEGRNDTSMDVLLKCEETLKMICQKSDIIKVKDRNINQPLLDAISAITKRERQKINLYEYFNFPLYQCSLKNTCPDCLKGICENETAQASNVEDSDQISIPLNIQREIGSLESKFRVTIDPSQRPLRSSCKFISVLCELLDITLPSVPPIYIRIPTNYPQSPPRYDLEWSQYCDSPYLNSIRKSLESFSSDTGAPNTISALLTNWETCVRDASFI
Length738
PositionTail
OrganismTrichinella nelsoni
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.05
Grand average of hydropathy-0.769
Instability index77.25
Isoelectric point7.98
Molecular weight84115.19
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05938
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     383.49|      58|      59|     250|     307|       1
---------------------------------------------------------------------------
   84-  127 (50.88/ 9.31)	.................QP..QRHQAP..VNQ.vpygnmqPGTQF....R......RADMRP.....M...QQPIQQQQQQQQQ
  128-  194 (77.19/18.62)	QQQQQ..VPGQIY..SGMR..APPNAE..MQP........RLLRPMHQPSvtmhhmHQQQAQmgqmgMTQ.SAGIAAAAQQQPQ
  217-  281 (91.14/23.56)	QLRQPNDIQQFLQ..QLPPaiRQQILQ..LPP...eeqaeQLKKFFESRR......WQQQQQ.....LHQ.QQQIQQQQQQQQQ
  282-  336 (94.30/24.67)	QQQQQQQIQQQIQ..HQQQ..QQQQLQ..VQQ....qiqhQMHHV.P............QNQ.....MHT.QAVIQQQQQQQQQ
  337-  404 (69.99/16.07)	QQQQQQQHQQQFAsvRQQQ..QMQMLQpmMQQpgavrfadQSTTMLYSRP......PATPVM.....IPQtPAPVQQPPSQ...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     119.97|      22|      54|     405|     426|       2
---------------------------------------------------------------------------
  405-  426 (44.14/28.31)	PAPVTP.MSGQAAS.PNVNIG...TPY
  431-  443 (26.96/13.93)	PAG.AH.MMG..PS.P.........AY
  444-  454 (19.71/ 7.85)	AAE.........TS.P...VC...HPA
  457-  483 (29.17/15.77)	PGPKTSqMSPAANSlPPESIGaehSPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     203.31|      50|      54|     555|     606|       3
---------------------------------------------------------------------------
  511-  547 (49.72/30.50)	.............SSQTQKFQRMVDILEGRND...TSMDVLLK..CEETLKMICQ
  555-  606 (83.67/64.30)	KDRNINQPllDAISAITKRERQKINLYEYFNF...PLYQCSLKNTCPDCLKGICE
  611-  661 (69.92/47.16)	QASNVEDS..DQISIPLNIQREIGSLESKFRVtidP.SQRPLRSSC.KFISVLCE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05938 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GAAAMSQPQRHQAPVNQVPYGNMQPGTQFRRADMRPMQQPIQQQQQQQQQQQQQQVPGQIYSGMRAPPNAEMQPRLLRPMHQPSVTMHHMHQQQAQMGQMGMTQSAGIAAAAQQQPQNVVMLLTSGNPPRQAASAPSAVQLRQPNDIQQFLQQ
2) QVQQQIQHQMHHVPQNQMHTQAVIQQQQQQQQQQQQQQQQHQQQFASVRQQQQMQMLQPMMQQPGAVRFADQSTTMLYSRPPATPVMIPQTPAPVQQPPSQPAPVTPMSGQAASPNVNIGTPYPSSSPAGAHMMGPSPAYAAETSPVCHPAATPGPKTSQMSPAANSLPPESIGAEHSP
78
304
230
482










Molecular Recognition Features






MoRF SequenceStartStop




NANANA