<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05937

Description Mediator of RNA polymerase II transcription subunit 15 (Fragment)
SequenceLQLFFLYFLSLIMEDDWRSQRQREKVIQHLDNVIRSCTVPLNIPGDARQVENAIFLKANNQEEYMQFVSKIIYHASSGAAAMSQPQRHQAPVNQVPYGNMQPGTQFRRADMRPMQQPIQQQQQQQQQQQQQQVPGQIYSGMRAPPNAEMQPRLLRPMHQPSVTMHHMHQQQAQMGQMGMTQSAGIAAAAQQQPQNVVMLLTSGNPPRQAASAPSAVQLRQPNDIQQFLQQLPPAIRQQILQLPPEEQAEQLKKFFESRRWQQQQQLHQQQQIQQQQQQQQQQQQQQQQIQQQIQHQQQQQQQLQVQQQIQHQMHHVPQNQMHTQAVIQQQQQQQQQQQQQQQQHFASVRQQQQMQMLQPMMQQPGAVRFADQSTTMLYSRPPATPVMIPQTPAPVQQPPSQPAPVTPMSGQAASPNVNIGTPYPSSSPAGAHMMGPSPAYAAETSPVCHPAATPGPKTSQMSPAANSLPPESIGAEHSPYKEKVNELLVYLEPLKRLIEQTKESTSDSSQTQKFQRMVDILEGRNDTSMDVLLKCEETLKMICQKSDIIKLCKQRELYVTVFSPDCLKGICENETAQASNVEDSDQISIPLNIQREIGSLESKFRVTIDPSQRPLRSSCKFISVLCELLDITLPSVPPIYIRIPTNYPQSPPRYDLEWSQYCDSPYLNSIRKSLESFSSDTGAPNTISALLTNWETCVRDASFI
Length704
PositionTail
OrganismTrichinella nelsoni
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.05
Grand average of hydropathy-0.750
Instability index79.44
Isoelectric point7.35
Molecular weight80053.65
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05937
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     301.16|      40|      41|      93|     132|       1
---------------------------------------------------------------------------
   93-  132 (84.19/27.17)	NQVPYGNMQ..PGTQFRRADM.......RP....MQ.QP......IQQQQQQ..............QQQQQQQQ
  135-  195 (42.07/ 9.45)	GQI.YSGMRapPNAEMQPRLL.......RP....MH.QPsvtmhhMHQQQAQmgqmgmtqsagiaaAAQQQPQN
  198-  238 (38.51/ 7.95)	MLLTSGN....PP...RQAAS.......APsavqLR.QP....ndIQQFLQQ..............LPPAIRQQ
  241-  278 (56.73/15.61)	QLPPEEQAE..QLKKF..FES.......RR....WQ.QQ......QQLHQQQ..............QIQQQQQQ
  314-  340 (43.90/10.21)	HHVPQNQMH...........................tQA......VIQQQQQ..............QQQQQQQQ
  362-  402 (35.74/ 6.78)	.Q......Q..PGA.VRFADQsttmlysRP....PA.TP....vmIPQTPAP..............VQQPPSQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.22|      15|      15|     281|     295|       2
---------------------------------------------------------------------------
  281-  295 (32.75/10.02)	QQQQQQQQIQQQIQH
  297-  311 (31.47/ 9.33)	QQQQQQLQVQQQIQH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.87|      16|      16|     423|     438|       3
---------------------------------------------------------------------------
  423-  438 (32.65/16.76)	YPS.SSPAGAHMMGPSP
  440-  456 (24.21/10.40)	YAAeTSPVCHPAATPGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.49|      10|      16|     594|     604|       4
---------------------------------------------------------------------------
  594-  604 (13.60/15.16)	QREIGSlESKF
  612-  621 (19.89/15.61)	QRPLRS.SCKF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.30|      14|      16|     656|     670|       5
---------------------------------------------------------------------------
  656-  670 (22.49/18.92)	LEwSQYCDSPYLNSI
  674-  687 (24.81/13.98)	LE.SFSSDTGAPNTI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05937 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GAAAMSQPQRHQAPVNQVPYGNMQPGTQFRRADMRPMQQPIQQQQQQQQQQQQQQVPGQIYSGMRAPPNAEMQPRLLRPMHQPSVTMHHMHQQQAQMGQMGMTQSAGIAAAAQQQPQNVVMLLTSGNPPRQAASAPSAVQLRQPNDIQQFLQQ
2) QVQQQIQHQMHHVPQNQMHTQAVIQQQQQQQQQQQQQQQQHFASVRQQQQMQMLQPMMQQPGAVRFADQSTTMLYSRPPATPVMIPQTPAPVQQPPSQPAPVTPMSGQAASPNVNIGTPYPSSSPAGAHMMGPSPAYAAETSPVCHPAATPGPKTSQMSPAANSLPPESIGAEHSP
78
304
230
479










Molecular Recognition Features






MoRF SequenceStartStop




NANANA