<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05919

Description Lysine-specific demethylase 8
SequenceMILLVRIGLALLQCCFGYTWSILECFFKKPKSVTDKVIVITGAARGIGKGLALLLAHLHAKIVLVDLDESTNKQTAEELRQETSACVYAYTADVTDPESMRQVANAIVTNPELGCPDVLVCSAGVLIPKLLEDHSDVEIYRTMNTIRAFYPYILKRGQGHIVAVSSYGGHFGNSYSCCYSASKFAVRGLMESLEWEIYDHGFGGEIKTTTIYPFFTRTDLLSSCNVTSDLIPVLTAEETSQGILKAILYEQTEAFIPFYGSLICYFFKGRTFKAIELEDFEAAVEICKFMLNFIWERLNTGHWSEVNISWRILYTMVSLLLSIAHIANGRLKDALCSCDKGLLLGCPISGNVLARLASLLHCKMIDTYPLEDMLINDKFDQALASMNDVCEHFEHCVPRVECPSLETFQRDFLIPQNPVVIEGALESWQAMEKWNIAYLMSKCAYRTVPIEIGSKYTNDEWSQKLLTITDFVHEYFNPDAREKAYLAQHQLFEQITELKDDIAVPDYCCLQCAPEDVDINAWFGPANTVSPLHTDPRDNLFAQVFGKKYLRLCHPTATKNLYPITDGLMSNTSQIDMEKIDYEKFPLVKNVKFYETIVKPGDLLFIPKATGIACDVMSSAGSAAVQSSLASGLLPSPSNLYYQSLGHITGGEGISRNGSRTPVSQRRVGHFTRARHHSSCDVHSLCDGVTFERCFDSQLPPADPQIHAGGLKGGFPFSARSSSNSYRQPTLSSHLSHGNLGYLQSDCDWSADLDPLVKNGRGSNEAPVCGSGSKIVNGRMTTTNCCPADCDALREDLRVAMEKLNATMGSIKSFWSPELKRERALRKEETAKMNMLQEQLKLSLVNNQKQSVLIEQLQNELRFQCNSGRSRRFPDDGPLIGHEDYRTVCQERDMYRRDWLISSDAVKELQYQLESQRQLLLSKDESVKRLLEALHSKGVPASVAQSCAEMELAQNRIVELEEKCSRLQAHCDDLESHLQQSHDGLSNLRKDAVIESLQDEVASYEAELKRLRSGGAIHEREFTDKMVTDKEYQELKLKADKLELELGQKTVEIQALYTRLSTAEESASDFKKHLELMKESNASKDQQATLLQSDIDALRGKLESKNEMIDQKAQQITELQADKNRLLSELNLLNEQHRISEVGLSTKDRKIDLLEETIRERDCELNLIRTRLNSSPGVIQEKKLQDEINRLVQERDLWRKRFNEEHECLAIERKRDGEAHEKENKDLRIAIASLQKEISDRQVNYYHFFIIISAVYKYDYGVFIESQNEKINDMVRQTEALTKENSLYKELNKTNGVDLLKAEIERLNQAVDESRSEVDRLLKIIHNSEKEKNEGRESGNDSKRFHSNTENADYQSVLMHKDRRIEELEEALKESVSITAEREMAVAQQKLNSQRAEQRIAALKDELKTLQEQYDELSIQLKQLRQEKVQSDATIKTMQEERKRYVDEVMQLKGEVLLAAIEEKDAHIAFLENFHGRKSSEEIDNVKKQKEELLQRLKEENARRVKLHNDPTLNFTDHFPKVSGIDLVRHWWPAMGIAWVYLYSDPEKSDRQDVLLDSLQTALDNMDAKQAGFFSLTSETFFSTTTTNAKPVHLFQSSEFPETTFVLVGDTLGSASTFLFAEKSITQMIRNLDGAYCTKPISKVECRGNKYVISDFTVRTSVATIASNFKGILVEIEYRPCVAMQLCGDLMKEFCTALLGSAASAPPTFVGLTKPNQRYVPIDTIFQYHCYFMHFRKMSVQTAGPNEQQSQAQPQPQQQQQQQQPQQQQQQQQQQQQQQQQQQQQQQQQQ
Length1790
PositionHead
OrganismTrichinella nelsoni
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.07
Grand average of hydropathy-0.469
Instability index48.55
Isoelectric point5.59
Molecular weight203510.40
Publications









Function






Annotated function


GO - Cellular Component
cytoplasm	GO:0005737	IEA:UniProtKB-SubCell
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
methyltransferase activity	GO:0008168	IEA:UniProtKB-KW
oxidoreductase activity	GO:0016491	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
methylation	GO:0032259	IEA:UniProtKB-KW
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05919
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.98|      16|      19|    1755|    1773|       1
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 1755- 1770 (34.90/18.25)	QPQQQQQQQQPQQQQQ
 1775- 1790 (33.08/10.65)	QQQQQQQQQQQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     302.64|      76|     100|     563|     662|       2
---------------------------------------------------------------------------
  482-  561 (98.67/92.96)	.....EKAYLAQH.QL...FEQITELKDDIAVPD..YCCLQCapedvDINAWFGPAN...TVSPLHTD..PR.DNL.FAQVFGkkylrlcHPTATKNL
  578-  654 (125.61/104.76)	EKIDYEKFPLVKNVKF...YETIVKPGDLLFIPK..ATGIAC.....DVMSSAGSAA...VQSSLASGlLPSPSNL.YYQSLG.......HITGGEGI
  676-  745 (78.37/48.20)	HHSSCDVHSLCDGVTFercFDSQLPPAD....PQihAGGLKG.....GFPFSARSSSnsyRQPTLSSH.L.SHGNLgYLQS.................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     172.49|      32|      32|    1152|    1183|       3
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  978- 1010 (30.18/14.64)	LQQSHDGLSnLRK..................DAVIESLQDEvasyEAEL....KR
 1011- 1059 (29.83/14.38)	LRSG.GAIH.EREftdkmvtdkeyqelklkaDKLELELGQK....TVEIQALYTR
 1152- 1171 (22.81/ 9.19)	...............................DLLEETIRER....DCELNLIRTR
 1172- 1201 (38.56/20.83)	LNSSPGVIQ.EKK................lqDEINRLVQER....D....LWRKR
 1405- 1423 (19.06/ 6.42)	...............................DELK.TLQEQ....YDELSIQLKQ
 1424- 1444 (32.05/16.02)	LRQE....K.VQS..................DATIKTMQE.......E....RKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.78|      19|      19|     897|     915|       4
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  897-  915 (33.94/24.41)	RDWLISSD.AVKELQYQLES
  917-  936 (26.84/17.54)	RQLLLSKDeSVKRLLEALHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.84|      18|      19|    1297|    1315|       5
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 1297- 1315 (24.70/18.97)	VD.LLKAeIERLNQAVDESR
 1318- 1336 (26.14/15.06)	VDrLLKI.IHNSEKEKNEGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.18|      19|     286|     111|     129|       8
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  111-  129 (35.94/23.11)	PELGCP...DVLVCSAGVLIPK
  344-  363 (20.03/ 9.31)	..LGCPisgNVLARLASLLHCK
  398-  416 (33.20/20.73)	PRVECP...SLETFQRDFLIPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.53|      14|      17|    1355|    1371|      10
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 1355- 1371 (17.23/15.68)	QSVLMHKDRrieELEEA
 1374- 1387 (20.31/ 9.56)	ESVSITAER...EMAVA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.51|      27|      34|    1446|    1473|      11
---------------------------------------------------------------------------
 1446- 1473 (39.42/27.50)	VDEVMQLKGEvLLAAIEEKDAHIAFLEN
 1483- 1509 (44.09/26.56)	IDNVKKQKEE.LLQRLKEENARRVKLHN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.59|      21|      23|    1104|    1125|      15
---------------------------------------------------------------------------
 1104- 1125 (31.10/21.88)	SKNEMIDQKaQQITELQ.ADKNR
 1128- 1149 (27.49/14.54)	SELNLLNEQ.HRISEVGlSTKDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.81|      23|     223|     220|     244|      16
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  220-  244 (34.26/28.07)	LLSSCNVTSdlIPV.....LTAEETSQGIL
  439-  466 (37.55/23.86)	LMSKCAYRT..VPIeigskYTNDEWSQKLL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05919 with Med20 domain of Kingdom Metazoa
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