<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05918

Description Lysine-specific demethylase 8
SequenceMILLVRIGLALLQCCFGYTWSILECFFKKPKSVTDKVIVITGAARGIGKGLALLLAHLHAKIVLVDLDESTNKQTAEELRQETSACVYAYTADVTDPESMRQVANAIVTNPELGCPDVLVCSAGVLIPKLLEDHSDVEIYRTMNTIRAFYPYILKRGQGHIVAVSSYGGHFGNSYSCCYSASKFAVRGLMESLEWEIYDHGFGGEIKTTTIYPFFTRTDLLSSCNVTSDLIPVLTAEETSQGILKAILYEQTEAFIPFYGSLICYFFKGRTFKAIELEDFEAAVEICKFMLNFIWERLNTGHWSEVNISWRILYTMVSLLLSIAHIANGRLKDALCSCDKGLLLGCPISGNVLARLASLLHCKMIDTYPLEDMLINDKFDQALASMNDVCEHFEHCVPRVECPSLETFQRDFLIPQNPVVIEGALESWQAMEKWNIAYLMSKCAYRTVPIEIGSKYTNDEWSQKLLTITDFVHEYFNPDAREKAYLAQHQLFEQITELKDDIAVPDYCCLQCAPEDVDINAWFGPANTVSPLHTDPRDNLFAQVFGKKYLRLCHPTATKNLYPITDGLMSNTSQIDMEKIDYEKFPLVKNVKFYETIVKPGDLLFIPKATGIACDVMSSAGSAAVQSSLASGLLPSPSNLYYQSLGHITGGEGISRNGSRTPVSQRRVGHFTRARHHSSCDVHSLCDGVTFERCFDSQLPPADPQIHAGGLKGGFPFSARSSSNSYRQPTLSSHLSHGNLGYLQSDCDWSADLDPLVKNGRGSNEAPVCGSGSKIVNGRMTTTNCCPADCDALREDLRVAMEKLNATMGSIKSFWSPELKRERALRKEETAKMNMLQEQLKLSLVNNQKQSVLIEQLQNELRFQCNSGRSRRFPDDGPLIGHEDYRTVCQERDMYRRDWLISSDAVKELQYQLESQRQLLLSKDESVKRLLEALHSKGVPASVAQSCAEMELAQNRIVELEEKCSRLQAHCDDLESHLQQSHDGLSNLRKDAVIESLQDEVASYEAELKRLRSGGAIHEREFTDKMVTDKEYQELKLKADKLELELGQKTVEIQALYTRLSTAEESASDFKKHLELMKESNASKDQQATLLQSDIDALRGKLESKNEMIDQKAQQITELQADKNRLLSELNLLNEQHRISEVGLSTKDRKIDLLEETIRERDCELNLIRTRLNSSPGVIQEKKLQDEINRLVQERDLWRKRFNEEHECLAIERKRDGEAHEKENKDLRIAIASLQKEISDRQVFIESQNEKINDMVRQTEALTKENSLYKELNKTNGVDLLKAEIERLNQAVDESRSEVDRLLKIIHNSEKEKNEGRESGNDSKRFHSNTENADYQSVLMHKDRRIEELEEALKESVSITAEREMAVAQQKLNSQRAEQRIAALKDELKTLQEQYDELSIQLKQLRQEKVQSDATIKTMQEERKRYVDEVMQLKGEVLLAAIEEKDAHIAFLENFHGRKSSEEIDNVKKQKEELLQRLKEENARRVKLHNDPTLNFTDHFPKVSGIDLVRHWWPAMGIAWYNRVYLYSDPEKSDRQDVLLDSLQTALDNMDAKQAGFFSLTSETFFSTTTTNAKPVHLFQSSEFPETTFVLVGDTLGSASTFLFAEKSITQMIRNLDGAYCTKPISKVECRGNKYVISDFTVRTSVATIASNFKGILVEIEYRPCVAMQLCGDLMKEFCTALLGSAASAPPTFVGLTKPNQRYVPIDTIFQYHCYFMHFRKMSVQTAGPNEQQSQAQPQPQQQQQQQQPQQQQQQQQQQQQQQQQQQQQQQQQQ
Length1774
PositionHead
OrganismTrichinella nelsoni
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.07
Grand average of hydropathy-0.483
Instability index48.82
Isoelectric point5.59
Molecular weight201586.20
Publications









Function






Annotated function


GO - Cellular Component
cytoplasm	GO:0005737	IEA:UniProtKB-SubCell
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
methyltransferase activity	GO:0008168	IEA:UniProtKB-KW
oxidoreductase activity	GO:0016491	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
methylation	GO:0032259	IEA:UniProtKB-KW
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05918
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.98|      16|      19|    1739|    1757|       1
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 1739- 1754 (34.90/23.19)	QPQQQQQQQQPQQQQQ
 1759- 1774 (33.08/13.53)	QQQQQQQQQQQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     214.16|      40|      41|    1165|    1204|       2
---------------------------------------------------------------------------
 1165- 1204 (67.25/37.90)	LNLIRTRLNSSPGVIQEKKLQD...E.INRLVQE.RDLWRKRFNE
 1209- 1246 (44.64/22.75)	LAIERKR....DGEAHEKENKDlriA.IASLQKEiSD..RQVFIE
 1265- 1296 (39.00/18.96)	ENSLYKELNKTNGV...DLLKA...E.IERLNQA.VDESR.....
 1371- 1396 (22.55/ 7.94)	......KLNSQRAEQRIAALKD...E.LKTLQEQ.YD........
 1398- 1428 (40.71/20.11)	LSIQLKQLR......QEKVQSD...AtIKTMQEE.R....KRYVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     176.11|      72|     285|     392|     465|       3
---------------------------------------------------------------------------
  392-  427 (42.02/23.87)	........................................................................................................................................................................................................................................................HFEHCVPRVECPSLeTFQRDF...LIPQNPVVIEGALES
  428-  465 (45.25/26.14)	WQAMEKWNiAYLMSKCAYRTVPIEIGSKYTNDEWSQKL.........................................................................................................................................................................................................................................................
  676-  713 (42.19/20.14)	......................................ltitdfvheyfnpdarekaylaqhqlfeqitelkddiavpdycclqcapedvdinawfgpantvsplhtdprdnlfaqvfgkkylrlchptatknlypitdglmsntsqidmekidyekfplvknvkfyetivkpgdllfipkatgiacdvmssagsaavqsslasgllpspsnlyyqslghitggegisrngsrtpvsqrrvghftrarHHSSCDVHSLCDGV.TFERCFdsqLPPADPQIHAGGLKG
  717-  753 (46.65/23.08)	FSARSSSN.SYRQPTLSSHLSHGNLGYLQSDCDWSADL.........................................................................................................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.68|      20|     228|     113|     132|       4
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  113-  132 (36.99/29.67)	LGCP...DVLVCSAGVLIPKLLE
  344-  366 (32.69/25.15)	LGCPisgNVLARLASLLHCKMID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.86|      37|     223|     265|     303|       6
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  265-  303 (63.98/47.26)	YFFKGRTFKAI.ELEDFEAAVEICkfMLNFIWERLNTGHW
  485-  522 (64.88/41.34)	YLAQHQLFEQItELKDDIAVPDYC..CLQCAPEDVDINAW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.42|      15|      18|    1553|    1570|       7
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 1553- 1570 (17.87/26.13)	KQAGFFSlTSEtfFSTTT
 1574- 1588 (28.54/21.70)	KPVHLFQ.SSE..FPETT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     264.66|     111|     223|     531|     667|       8
---------------------------------------------------------------------------
  136-  205 (95.41/51.91)	DVEIYRTMNTIRaFYPYILKRGQGHIVA.VSSYGGHFGNSYSCCYSASKFAvRGLM...ESLEWEIYDHGFGGE.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  532-  574 (48.09/21.28)	.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................iktttiypfftrtdllsscnvtsdlipvltaeetsqgilkailyeqteafipfygslicyffkgrtfkaieledfeaaveickfmlnfiwerlntghwsevniswrilytmvslllsiahiangrlkdalcscdkglllgcpisgnvlarlasllhckmidtypledmlindkfdqalasmndvcehfehcvprvecpsletfqrdflipqnpvviegaleswqamekwniaylmskcayrtvpieigskytndewsqklltitdfvheyfnpdarekaylaqhqlfeqitelkddiavpdycclqcapedvdinawfgpantvspLHTDPRDNL...FAQVFGKKYLRLCHPT...ATKN.LYPITDGLMSNTSQ
  581-  652 (82.70/93.14)	DYEKFPLVKNVK.FYETIVKPGDLLFIPkATGIACDVMSSAGSAAVQSSLA.SGLLpspSNLYYQSLGHITGGE.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1488- 1537 (38.45/12.02)	..........................................................................gisrngsrtpvsqrrvghftrarhhsscdvhslcdgvtfercfdsqlppadpqihagglkggfpfsarsssnsyrqptlsshlshgnlgylqsdcdwsadldplvkngrgsneapvcgsgskivngrmtttnccpadcdalredlrvameklnatmgsiksfwspelkreralrkeetakmnmlqeqlklslvnnqkqsvlieqlqnelrfqcnsgrsrrfpddgplighedyrtvcqerdmyrrdwlissdavkelqyqlesqrqlllskdesvkrllealhskgvpasvaqscaemelaqnriveleekcsrlqahcddleshlqqshdglsnlrkdavieslqdevasyeaelkrlrsggaihereftdkmvtdkeyqelklkadklelelgqktveiqalytrlstaeesasdfkkhlelmkesnaskdqqatllqsdidalrgklesknemidqkaqqitelqadknrllselnllneqhrisevglstkdrkidlleetirerdcelnlirtrlnsspgviqekklqdeinrlvqerdlwrkrfneeheclaierkrdgeahekenkdlriaiaslqkeisdrqvfiesqnekindmvrqtealtkenslykelnktngvdllkaeierlnqavdesrsevdrllkiihnsekeknegresgndskrfhsntenadyqsvlmhkdrrieeleealkesvsitaeremavaqqklnsqraeqriaalkdelktlqeqydelsiqlkqlrqekvqsdatiktmqeerkryvdevmqlkgevllaaieekdahiaflenfhgrksseeidnvkkqkeellqrlkeenarrvkLHNDPTLNFtdhFPKVSGIDLVRHWWPAmgiAWYNrVYLYSDPEKSDRQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.17|      13|      19|     832|     844|       9
---------------------------------------------------------------------------
  832-  844 (22.06/15.88)	KMNMLQEQLKLSL
  849-  861 (21.11/14.80)	KQSVLIEQLQNEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     245.79|      65|     140|     920|     988|      10
---------------------------------------------------------------------------
  920-  985 (99.30/68.04)	LLSKDESVKRL...LEALHSKGVPASVAQSCAEM..ELAQnRIVELEEKCSRL...QAHCDDLESHLQQSHDGL
 1016- 1079 (76.64/42.79)	AIHEREFTDKM...VTDKEYQELKLKADK..LEL..ELGQ.KTVEIQALYTRLstaEESASDFKKHLELMKE..
 1083- 1144 (69.84/43.86)	..SKDQQATLLqsdIDALRGK.....L.ESKNEMidQKAQ.QITELQADKNRL...LSELNLLNEQHRISEVGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.29|      14|      18|    1331|    1344|      11
---------------------------------------------------------------------------
 1331- 1344 (24.86/17.18)	ENADYQSVLMHKDR
 1350- 1363 (21.43/13.73)	EEALKESVSITAER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.50|      19|      34|    1429|    1448|      12
---------------------------------------------------------------------------
 1429- 1448 (26.25/20.90)	EVMQLKGEvLLAAIEEKDAH
 1466- 1484 (30.25/19.21)	NVKKQKEE.LLQRLKEENAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.06|      18|     451|     322|     339|      13
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  322-  339 (33.88/22.12)	SIAHIANGRLKDALC...SCD
  771-  791 (30.17/18.85)	SGSKIVNGRMTTTNCcpaDCD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05918 with Med20 domain of Kingdom Metazoa
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