<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05917

Description Coiled-coil domain-containing protein 47
SequenceMESRDVLYATPYRPKSSAAHVFESIKPTPLLNITPECSEDDDCNSGTSEKSSDKTLKREIADSSLHSCYHGKQLNRPFLNTCEAIIEKIKRVKKIDPSTLAKEQIRRNEHYYQKIAMKKENARSIVQNIKSIQSSISEVLAKLQMADQPSLLNSFRVISSQFNSMLQLLRSDRASHFKNYVFLPIRLSVEVDADLEAATENRLHAWTHAVVPDYLRTKPDPQVEQKDQQISNQVQQRICNPESLQKQITAFNRCLNCILDSLNASIRDSEMDGRKTSKTSDGEDTALLVAAILKGQNVKPAYSATPASSRGSSGDSGRKTCIWMFFLSCLFELVELSVKQVSQIDDNEFAEFEEFDVELDASVDADFTANNVNERETPPVDTASIGAKRSPANAEQKRNDAPNNNFNDDDYGIVEDDESVDDFSHLLDENEFENFPDERRPGKQNAGPSKTVTQLKITDVPGHLRNNWNNFVVELFLIFGLIVYTKNHSLAVAWFDSNRPFLEENFSIVGDDGISPEVTKNVLIKESDNHYIVWCSGRQGCIGMEIHLKLIKRQDLLSLIFYIIRPKFDIIEVKIILNPEEMDPFVFALGTKRSAIKNSKEIMDLNLYCSEKKNVEKLGLPSSYILHSEIGEVTTGLIDSKIVSALCKYKDVVDYIHISDQFVGIKPIEMENMTKPPETAKVVMICLNIPGQLRATEEDVSSLQPLMIFIFHVLEKVRRFRLTREGKQKADKNRQYVEESFLKTTHAQRQEAAQQRREERARERKERLMAEEDPERQRKLEKQELKRELKKKQPRVKQIKIKAMLQFLIKAKQIYC
Length816
PositionHead
OrganismTrichinella nelsoni
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.07
Grand average of hydropathy-0.546
Instability index47.29
Isoelectric point6.23
Molecular weight93282.03
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro
rough endoplasmic reticulum membrane	GO:0030867	IEA:UniProtKB-SubCell

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05917
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.18|      34|     636|      20|     123|       3
---------------------------------------------------------------------------
   75-  111 (53.89/104.76)	NRPFLNTCEAIIEKIKRVKKIDPSTLAKEQirrNEHY
  498-  531 (59.29/ 8.61)	NRPFLEENFSIVGDDGISPEVTKNVLIKES...DNHY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.39|      17|     636|      20|      36|       4
---------------------------------------------------------------------------
   20-   36 (32.62/22.15)	HV...FESIKPTPLLNIT..PE
  657-  678 (23.77/14.21)	HIsdqFVGIKPIEMENMTkpPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.11|      28|      32|     724|     755|       7
---------------------------------------------------------------------------
  724-  751 (46.53/35.80)	REGKQKADKNRQYVEESFLKTTHAQRQE
  757-  784 (45.58/25.07)	REERARERKERLMAEEDPERQRKLEKQE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.84|      39|      54|     346|     386|      10
---------------------------------------------------------------------------
  346-  386 (60.63/47.65)	DNEFAEFEEFDVELDASVDaDFT.ANNVNERETPPvDTASIG
  403-  442 (68.21/44.44)	NNNFNDDDYGIVEDDESVD.DFShLLDENEFENFP.DERRPG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05917 with Med8 domain of Kingdom Metazoa
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