<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05904

Description Mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMASCTVAWEKKPLKRPRLGQPDDELTAEKVRQGFIYKPPLLNEYESLRSQRFDENLEDYFIKLTQSYNAIVNKKAEINALQDSYKKKSGFKEPSIWHFFIAPLAAKPKGQDTWFKDLSGNKPLSALGKRFPFLNKKDEILYTLAEFNVPMVRVVWFLKMTNAHIAQQQECGKMKKKHMSDPFADWTHLVMKYLRDLCSKLGEFFSLNLEVPMNSEFECHYRHWQYTAKLTRHLFEEGLLDKEILLNGLLDIFAEKIYASSFGILKMLVPVLLQFIDGFVMSVLLSRRLVYLACKVLSAMKIDNLQNNSENIKEEEEEESTLDYLNCPFHRTVLFGLSNVIHAVLIDCPTALIWNEMECEDTGENGKAYLCGSPLDLLHCSPVDLPLFMDPSTEFVKKELERLTEMVTERSRAVESHWSYNKCQHSGLSESTIIQHFLSILDCLDKFKFEYVNETNNIDTLYKTIFQSEKKEMRVDVDSIAVQFLCHWAVSPHRYGSYRAAVVTRLFERHLQEVKHDEFQLSKKMPQVRHPFQKSLFNYLHNQAPNLGEMCSSSEIKPFTNLILLFSRLIESDIFSHDQYVSTLVSSGDLIPNGANIFYPLQNQCSSSSSAVENVSNTQPAVLMSSNLFSEQFKPIENVDFNYFKDSDESKLDFDRIIDFADNKKAISSDTDSCSSKRVPKLSKHYFNVLHFPVPQDDQYRHECNQRQLLLFGSNSDQYSRKHILKKLTKELNKLWSKKTSAELTTNGLIRVRKIIDSESLCSLSRKIQNLVFYDQFAVMDCCCDSGIAQFNSFISGQSNCLPTLENFDFLLGLLEESSNFISLVEFVEAIICLLPKLEAQIVERNFHCANSLTLQYAVCMVGYMRKHHCYFIQLESVMCNIWRSLLLYVKSKTVVNSFSAERCVWVYLHDLYQCCSYIRSLHADLYLNSRDCIQRCLCVETKPSCCNDLRTLLADVSRDIMLDVLFQESDLVIEPNLIQRLVENANLCYAFAIVAVKALCGLSGDTERLFNLVLFCADVTALCPNLNADWLAVFKILCCPFNSSQDQSSCDSLLNIDVSDHQCYQPLTVLVITLISRMCIRLEDFILHVAMPSLLPLWKHAGSAKVEKGSEASAKLTLHLLGKILLFFDYQGPKNALPAKTKGELSLICSSVDGMVPDAILTLLIAILMLDDSKVQELKSKENFDTKRSAAKQFVEEDTNTAGNSDIGSTAIQLLELICRQEWTKRKFLHSTDLFDPKRLLNPLVNQTQAQRLLRMITRSDSEILLKKFDSCTTKKELISKVLDSLTIMNLWVSQMDLQLLLKQVANSQSESLHLVDTIAKSCMEVFQPQATLAFGEPSDDKDENAYLNALSFDEIAPYWLVAPLISRLPSFVQGRVLKAAVSILENCQARRDRNLFVQSSSLLAHQPFLSLVLICLRGQDDQREGLLSSLLKQIQEFVMRVKEDPYILCDRDIVSEMLDALQLRLSLIGGMFDTVCRNANLENWSLVMVQLLLYGIVTEEKNQALFYTCVDILCVLLLSCLLPDSAGFSFSGQERTNEDCKRIYNNVIKKLKVKEIGDRQVSSLRCVHQLLPIPRQMVDIIVCDEYGSQPQKGSRGGFSSSEVTQRKGLQIIGKEKLNPWEIIEGYNRENIGLKWSWFQGIRLDYQPETLFEQMMRMLPHDHHHAFNRPPMPGEPRSDPFLETLQVHYLPCTNETSDSDKLTTERLKSNGSVAISGGTLVSEFSDQVQSPRTTKARARKSTRGRKTSSRVTVSSNVALSSVPPMVQNRQLGIGQPTLTAHYGYYPQQVAMTGGPSGAVPPYGQGQMWSIGNVQSASTAVPPTQYQSRNFTGAQMAPMQSSSGKQAISAMIRGRRPSGSGGQQMMTTAHIQAAPLATGQPYHQQQLHSIGQVDPMVAPMHQVQMQMDARQQLMQESMMEQQIRTPGPRSMATQQHCLPQVNSAASQPVMHGNYSNYPGQHGGGRMQMTSARNQYAAQQPAQPPFNCSPNYNAQFYQAQNAGQMRMSQTDVIGQSNVRYTQQPNAIGSSYQMQSQQTLRAPAGYVAQQANPMYAAPNTPQYQAAQQQNVSMYPVSRMSQYSSNVPGQEMNASQQQINYYPPQY
Length2102
PositionKinase
OrganismTrichinella nelsoni
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.09
Grand average of hydropathy-0.266
Instability index48.83
Isoelectric point6.66
Molecular weight238313.62
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05904
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     414.98|     130|     191|    1215|    1349|       1
---------------------------------------------------------------------------
  227-  304 (49.20/27.32)	......AKLTRHLF..EEGLLDKEILLNGLL.difaEKIYASSfgILKMlvpvLLQFIDGFVM........SVLLSRRLVylaCKVLSAMKI...............DNL.....................................................................
 1215- 1349 (204.02/165.75)	LElICRQEWTKRKFLHSTDLFDPKRLLNPLV.....NQTQAQR..LLRM....ITRSDSEILLK....KFDSCTTKKELI...SKVLDSLTI...............MNL..WvSQMDLQLLLKQ.VANSQSESLHL..VDTIaksC...MEVFQP.QATLAF.GEPSDDKD.ENAYLN
 1385- 1547 (161.76/116.13)	LE.NCQARRDRNLFVQSSSLLAHQPFLSLVLiclrgQDDQREG..LLSS....LLKQIQEFVMRvkedPYILC..DRDIV...SEMLDALQLrlsliggmfdtvcrnANLenW.SLVMVQLLLYGiVTEEKNQALFYtcVDIL...CvllLSCLLPdSAGFSFsGQERTNEDcKRIYNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     294.50|      55|      68|    1953|    2007|       2
---------------------------------------------------------------------------
 1856- 1908 (62.98/37.32)	....PSGSGGQQM.MTT.....AHIQAAPLATGQPYHqqqlhsigQV..DP.MVAPMHQV....QM...QMDA
 1921- 1951 (32.99/15.43)	QIRTPGPRSMATQQHCL.....PQVNSAASQPVMHG.....................................
 1953- 2007 (107.74/69.99)	YSNYPGQHGGGRMQMTS.....ARNQYAAQQPAQPPF........NC..SPNYNAQFYQAQNAGQM...RMSQ
 2018- 2078 (70.39/42.73)	YTQQPNAIGSS.YQMQSqqtlrAPAGYVAQQ.ANPMY........AApnTPQYQAA..QQQNVSMYpvsRMSQ
 2080- 2101 (20.40/ 6.24)	SSNVPGQEMNASQQQI........NYYPPQ...........................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     107.65|      20|      67|     867|     886|       3
---------------------------------------------------------------------------
  867-  886 (37.97/20.16)	HHCYFIQLESVM..CNIWRSLL
  901-  922 (33.10/16.62)	ERCVWVYLHDLYqcCSYIRSLH
  934-  953 (36.58/19.15)	QRCLCVETKPSC..CNDLRTLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.71|      34|      60|     505|     564|       5
---------------------------------------------------------------------------
  505-  542 (51.74/63.98)	LFERHLqeVKHDEF..QLSKKMPQVrhPFQKSLFNYLHNQ
  568-  603 (54.96/19.85)	LIESDI..FSHDQYvsTLVSSGDLI..PNGANIFYPLQNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.15|      14|      56|    1756|    1771|       7
---------------------------------------------------------------------------
 1756- 1769 (23.74/ 8.12)	NVALSSVPPMVQNR
 1841- 1854 (18.40/10.20)	SSGKQAISAMIRGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.99|      32|      36|     772|     807|       8
---------------------------------------------------------------------------
  772-  807 (49.46/41.54)	FYdqFAVMDccCDSGIAQFNSFISGQSNCLPTLE......NF
  809-  846 (46.53/25.45)	FL..LGLLE..ESSNFISLVEFVEAIICLLPKLEaqiverNF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.39|      26|      37|    1691|    1716|       9
---------------------------------------------------------------------------
 1691- 1716 (44.19/31.42)	PCTNETSD...SDKLTTERL.......KSNGSVAIS
 1719- 1754 (30.20/18.87)	TLVSEFSDqvqSPRTTKARArkstrgrKTSSRVTVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.28|      36|     190|     443|     478|      11
---------------------------------------------------------------------------
  443-  478 (60.14/35.85)	LDKFKFEYVNETNNIDTLYKTI..FQSEKKEMRVDVDS
  635-  672 (55.14/32.29)	IENVDFNYFKDSDESKLDFDRIidFADNKKAISSDTDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.71|      30|      72|     988|    1017|      12
---------------------------------------------------------------------------
  988- 1017 (53.70/35.16)	CYAFAIVAVKALC.GLSGDTERLFNLVLFC....A
 1019- 1044 (20.50/ 8.58)	........VTALCpNLNADWLAVFK.ILCCpfnsS
 1063- 1090 (47.51/30.21)	CYQPLTVLVITL...ISRMCIRLEDFILHV....A
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.43|      21|      38|    1773|    1793|      15
---------------------------------------------------------------------------
 1773- 1793 (40.72/25.85)	IG..QPTLTAHYGYYPQQVAMTG
 1810- 1832 (33.72/20.05)	IGnvQSASTAVPPTQYQSRNFTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.32|      14|     663|    1132|    1145|      18
---------------------------------------------------------------------------
 1132- 1145 (24.89/14.90)	GPKNALPAKTKGEL
 1794- 1807 (28.44/18.23)	GPSGAVPPYGQGQM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05904 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IGNVQSASTAVPPTQYQSRNFTGAQMAPMQSSSGKQAISAMIRGRRPSGSGGQQMMTTAHIQAAPLATGQPYHQQQLHSIGQVDPMVAPMHQVQMQMDARQQLMQESMMEQQIRTPGPRSMATQQHCLPQVNSAASQPVMHGNYSNYPGQHGGGRMQMTSARNQYAAQQPAQPP
2) LVSEFSDQVQSPRTTKARARKSTRGRKTSSRVTVSSNVALSSVPPMVQNRQLGI
1810
1720
1983
1773










Molecular Recognition Features






MoRF SequenceStartStop




1) YYPPQY
2097
2102