<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05903

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSGDEETMDFEEKLAAFPLPSIPANQGPPFMAFGVLLDFAVQKTYQDFVILTDLLPKKSDLDRKISIAQFAHSARQLFVRLYAILKWARCGAKVDLCTGIVCFLDQQASMFVDTADRLYQMNCDVLQNARLPVFQIPTAVDVLTLGTYPRLPSVIKREFIRTADISQEEEECVLHRLNYVIERRLLPSLLTLPEGMRNFTVNNGMVTFHVAGEFEAQLTLLGQLPRTPWTLLNLRILVSDPRVTDGSDILSSLQLSFLHHLIQSRLNVSKEPIVELYRVIHCFCLSAQLDILCCQAYRLIGDFMSENLSVEEYVSSEKLVLSYWKEQNQGGVASFKVIFWINQDEPFAPLQVTHIPKSELKLPSMDTESGQLSLDNLLTETVLIRVKHRLQQLCDYLRTIKGLTCTFISDMPALSITFLPDSSFTETLDLSMNLFTGKFVCRLPAFDEDISLIAQLTEKLDDSHWNCLEDLLHQIRVRLFVNRIDHTMRFFTLKSCETLPAFLKTACEQWPVDRRFIIKFHRFENYYIVLTFNDHPDDSAKVNLDFWLVCNETMSNAIRSADADDDDRSKKNVNLLHFDLRRVVSETKVFHQLCLFSWKIQKKQCVIPELMAAFSMCENAMPFFLLMEEMERTSARYAYHQLFDGTVVLRVLGIDQTYDRNVEKIFGLPKGLAIGLSCDRHRVVWSIELNTTGSPLGDSSSFGRAVHRKITILSCTVGNESARKCLDDVLSGVRCFNALYEPVKALAGAYKSCLHRLTPLSMLSSYKLTLVYGPMLRYVCHLQWKPSEKMYILSFGVDNSVLNEEYVYFNPHSILCGHLQHWFNAVRDISALAHLLQASSAALQALTTLPDTIFRVGSEHTSNQMLYLNRMFSILPTGPDTVRLLCKDHLCLEMRFTFSGSVFMRDCGSAFGLPQMKSVKYVPITGFKTFLNLHISEVKAAIEAERKVSTAVHDSLMEVSDVDFSGNSGTGSSMVLENSMRTSTQNRLIGNSLANDDGHAEPSSRSPPEDWTPCVVPIEIQQSAFIRICSPSGTHPHPEWSHLQKFILSVEVLEKMKEQANNFTVIRPGQLSLKCNQSEMKFFLNESNLSSVMFKFFRDENDACTESDVQFLEKYFLEQISSTYNAAAMYAFVRMLTVCQTIRRDLLSSFLSIMNIQQHAYVESSTAYWIPEMCFLIPSPQLVPTTYLSRATLMPGGLAIVANVVQKKMLFWIKFVRVADPSHCVAFPFLYDGENNSLQVFRGTNQQTAQQSNSTVYPIETCLLRQQQTHSAFSECVVWPCIRDVMHINELIPGRS
Length1296
PositionTail
OrganismTrichinella nelsoni
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.10
Grand average of hydropathy-0.019
Instability index44.51
Isoelectric point6.04
Molecular weight147389.40
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05903
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.53|      40|     696|     196|     236|       1
---------------------------------------------------------------------------
  196-  236 (67.84/50.47)	MRnFTVNNGMVTFHVAGEF.EAQLTLLGQLPRTPW.TLLNLRI
  894-  935 (63.69/42.22)	MR.FTFSGSVFMRDCGSAFgLPQMKSVKYVPITGFkTFLNLHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     248.17|      69|     310|     273|     343|       2
---------------------------------------------------------------------------
  273-  314 (59.12/37.99)	...........................................................IVEL.Y..RVIH........................................................................................................................................................CFCL.SAQLDI.LCCQAYRLIGDF.MSEN.....LSVEEYV
  317-  343 (25.44/14.37)	EKLVLSYWKEQNQGGVASFKVIFWINQ.............................................................................................................................................................................................................................................
  496-  527 (35.22/18.92)	.......................................................................depfaplqvthipkselklpsmdtesgqlsldnlltetvlirvkhrlqqlcdylrtikgltctfisdmpalsitflpdssftetldlsmnlftgkfvcrlpafdedisliaqlteklddshwncledllhqirvrlfvnridhtmrfftlksCETL.PAFLKT..ACEQWPVDRRF.IIKF.....HRFENYY
  528-  630 (62.44/40.63)	..IVLTF..NDHPDDSAKVNLDFWLVCnetmsnairsadaddddrskknvnllhfdlrrVVSE.T..KVFH........................................................................................................................................................QLCLfSWKIQK.KQCVIPELMAAFsMCENampffLLMEEM.
  631-  688 (65.95/40.25)	ERTSARYAYHQLFDGTVVLRVL.GIDQ....................................tYdrNVEK........................................................................................................................................................IFGL.PKGLAIgLSCDRHRVV.............WSIE...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     153.12|      46|     697|     370|     442|       3
---------------------------------------------------------------------------
   72-  122 (71.12/24.29)	HSARQLFVRLYAIlKWARCGAKVDLCTGIVCFLDQqaSMFVDTADrlYQMN
  388-  433 (82.00/70.58)	HRLQQLCDYLRTI.KGLTCTFISDMPALSITFLPD..SSFTETLD..LSMN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.19|      32|     108|     839|     871|       6
---------------------------------------------------------------------------
  839-  871 (50.68/42.15)	SSAALQALTTLPDTIFRvGSEHTSNQMLYLNRM
  949-  980 (54.51/40.30)	STAVHDSLMEVSDVDFS.GNSGTGSSMVLENSM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05903 with Med14 domain of Kingdom Metazoa
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