<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05900

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSGDEETMDFEEKLAAFPLPSIPANQGPPFMAFGVLLDFAVQKTYQDFVILTDLLPKKSDLDRKISIAQFAHSARQLFVRLYAILKWARCGAKVDLCTGIVCFLDQQASMFVDTADRLYQMNCDVLQNARLPVFQIPTAVDVLTLGTYPRLPSVIKREFIRTADISQEEEECVLHRLNYVIERRLLPSLLTLPEGMRNFTVNNGMVTFHVAGEFEAQLTLLGQLPRTPWTLLNLRILVSDPRVTDGSDILSSLQLSFLHHLIQSRLNVSKEPIVELYRVIHCFCLSAQLDILCCQAYRLIGDFMSENLSVEEYVSSEKLVLSYWKEQNQGGVASFKVIFWINQDEPFAPLQVTHIPKSELKLPSMDTESGQLSLDNLLTETVLIRVKHRLQQLCDYLRTIKGLTCTFISDMPALSITFLPDSSFTETLDLSMNLFTGKFVCRLPAFDEDISLIAQLTEKLDDSHWNCLEDLLHQIRVRLFVNRIDHTMRFFTLKSCETLPAFLKTACEQWPVDRRFIIKFHRFENYYIVLTFNDHPDDSAKVNLDFWLVCNETMSNAIRSADADDDDRSKKNVNLLHFDLRRVVSETKVKKQCVIPELMAAFSMCENAMPFFLLMEEMERTSARYAYHQLFDGTVVLRVLGIDQTYDRNVEKIFGLPKGLAIGLSCDRHRVVWSIELNTTGSPLGDSSSFGRAVHRKITILSCTVGNESARKCLDDVLSGVRCFNALYEPVKALAGAYKSCLHRLTPLSMLSSYKLTLVYGPMLRYVCHLQWKPSEKMYILSFGVDNSVLNEEYVYFNPHSILCGHLQHWFNAVRDISALAHLLQASSAALQALTTLPDTIFRVGSEHTSNQMLYLNRMFSILPTGPDTVRLLCKDHLCLEMRFTFSGSVFMRDCGSAFGLPQMKSVKYVPITGFKTFLNLHISEVKAAIEAERKVSTAVHDSLMEVSDVDFSGNSGTGSSMVLENSMRTSTQNRLIGNSLANDDGHAEPSSRSPPEDWTPCVVPIEIQQSAFIRICSPSGTHPHPEWSHLQKFILSVEVLEKMKEQANNFTVIRPGQLSLKCNQSEMKFFLNESNLSSVMFKFFRDENDACTESDVQFLEKYFLEQISSTYNAAAMYAFVRMLTVCQTIRRDLLSSFLSIMNIQQHAYVESSTAYWIPEMCFLIPSPQLVPTTYLSRATLMPGGLAIVANVVQKKMLFWIKFVRVADPSHCVAFPFLYDGENNSLQVFRGTNQQTAQQSNSTVYPIETCLLRQQQTHSAFSECVVWPCIRDVMHINELIPGRS
Length1284
PositionTail
OrganismTrichinella nelsoni
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.10
Grand average of hydropathy-0.022
Instability index44.73
Isoelectric point5.99
Molecular weight145857.58
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05900
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.53|      40|     684|     196|     236|       1
---------------------------------------------------------------------------
  196-  236 (67.84/40.13)	MRnFTVNNGMVTFHVAGEF.EAQLTLLGQLPRTPW.TLLNLRI
  882-  923 (63.69/33.53)	MR.FTFSGSVFMRDCGSAFgLPQMKSVKYVPITGFkTFLNLHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.59|      19|     108|     484|     503|       2
---------------------------------------------------------------------------
  428-  446 (36.37/16.17)	LDLSMNLFTGKFVCRLPAF
  484-  502 (37.22/21.01)	IDHTMRFFTLKSCETLPAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.69|      23|     801|     271|     324|       3
---------------------------------------------------------------------------
  299-  324 (36.81/69.19)	LIGDFMS.ENLSVEEYVSSEKlvlSYW
 1134- 1157 (37.88/ 9.22)	LLSSFLSiMNIQQHAYVESST...AYW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     255.39|      81|     456|     530|     613|       5
---------------------------------------------------------------------------
  530-  613 (134.88/93.89)	LTFND.HPDDSAKVNLDFWLVCN...ETMSNA.IRSADADDDDRSKKNVNLLHFDLRRVVSEtKVKKQC....VIPElmAAFSM.C.ENAMPFFL
  981- 1072 (120.51/74.21)	LANDDgHAEPSSRSPPEDWTPCVvpiEIQQSAfIRICSPSGTHPHPEWSHLQKFILSVEVLE.KMKEQAnnftVIRP..GQLSLkCnQSEMKFFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.91|      25|     633|      63|      90|       7
---------------------------------------------------------------------------
   63-   90 (40.63/34.88)	RKISIAQFA...HSARQLfvrLYAILKWARC
  696-  723 (40.28/25.62)	RKITILSCTvgnESARKC...LDDVLSGVRC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.19|      32|     108|     827|     859|       8
---------------------------------------------------------------------------
  827-  859 (50.68/34.23)	SSAALQALTTLPDTIFRvGSEHTSNQMLYLNRM
  937-  968 (54.51/32.73)	STAVHDSLMEVSDVDFS.GNSGTGSSMVLENSM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05900 with Med14 domain of Kingdom Metazoa
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