<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05894

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLMMEDGINVDDLFGENASLDLGLPPGNSTVSAKGLAQRLDETRLLGCCQKIAWSRFGCIAYISQNSTRVNVRHLHCQPSDGRWVLSEETPLNQITEAHGGHTLVHLCWNEAGSELAVADSSGRVSICSIPIALNSVNGARPAILDTEDDGGQIVGMMWLNQQRSVHSFYQAAKVQGRWAYSPFRRRPIGPFHAAGKAALLCITRSGVMKLLYQNPDNRWAEITAELKNTSYSDRLLTHAAIVATQAGILIATHSACQKISLYRVQIQWNPPQWDQAQQKQNPPQFPVPSFRFLHAKVEVPYNIPSHRGVGGNPDEQFPVTNSLYCLTSLQIILPASDNSAGSTPNPWVVAVFSIPPLAVLHHQQPQVPSSVIVRWQLESGVPTLHPKFDEVNSKKSNVQIKPKTVLRRLDDITSDRHVISVDQTEYGNVLAISYDDSSIAFYDPKTMAVFSGVDDANTVTSLAQAGFHYPLDSPALHISFSPSACVAVGLDSDGQTHLRVMQHSYGEESGFYDENKFSAAIAALTLGFCRGCGGEVNTDDILLILVRQLSPDYQSAFINEVYRALTINCNFTTEQDKLMNHPYIPRALSIQAALSFTGKYKSRAITSAVPWAILQLRQAAFIYPFFFQYNKGVQAAEPHDPDVLRMVLGNTRWALDFSLYILNELFDLADEFESVASDQEAFTQKLKSTTSLPLIILLSSMSRAFLRFICRGLRGIHAGYASSAPLTGDAHVHYTEICQTLDASPVRIDVYEKFLAGVDSAVKHAYTGSGFGDNERPAPEKELLMNSRIPPVLVNAVSTILRQTVPAMRGEMDRMAIYLGDYSWLGFGTDAKTEAYRRSREVDIIKKTPVMGVPNVDGTSQGSKNGTNSTNNGSGTPQGVLRRRCVRCCEVSEAVYPPRSVLAFRMIYKLGHLRACICGGMWNLESGVTS
Length932
PositionTail
OrganismAspergillus calidoustus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Nidulantes.
Aromaticity0.08
Grand average of hydropathy-0.156
Instability index43.53
Isoelectric point6.60
Molecular weight102633.45
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05894
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     375.72|      85|     179|     234|     318|       1
---------------------------------------------------------------------------
  175-  244 (59.82/28.96)	....................KVQGRWAYSP........F.........RRR....PIGPF...HAA...GKAALLCITRSGVmkllYQNPDNRwaeitaelkntsySD.RL..LTHA.AIV
  245-  334 (135.47/74.57)	ATQAGILIATHSACQKISLYRVQIQWNPPQ........WDQAQQ....KQNPPQFPVPSFRFLHAK...VEVPYNIPSHRGV....GGNPDEQ..........fpvTN.SLycLTSL.QII
  344-  424 (78.39/40.16)	STPNPWVVAVFSIPPLAVLHHQQ.....PQvpssvivrW...QL....ESGVPTLH.PKFDEVNSKksnVQIKPKTVLRR.....................ldditSD.R.....HViSVD
  425-  505 (102.05/54.42)	QTEYGNVLAISYDDSSIAFYDPKTMAVFSG........VDDANTvtslAQAGFHYPLDS.PALH.......ISFSPSACVAV....GLDSDGQ.............THlRV..MQH.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.82|      17|     203|     708|     724|       2
---------------------------------------------------------------------------
  708-  724 (32.58/18.65)	LR.FICRGLRGIHAGYAS
  915-  932 (30.23/16.82)	LRaCICGGMWNLESGVTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.85|      14|     203|     576|     590|       3
---------------------------------------------------------------------------
  576-  590 (21.11/17.82)	EQDKLMNhPYIPRAL
  782-  795 (22.74/12.83)	EKELLMN.SRIPPVL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05894 with Med16 domain of Kingdom Fungi
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