<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05889

Description Putative Mediator of RNA polymerase II transcription subunit 12
SequenceMIPHSSAGVQAWGKPLRTVDNGPGRVDASQALNLADFRSEKQSTPVLSAHSAPPAVIDLTSSAGDTQEREPPAKRLKLDASAGSFPTDASLAATSGGVARNTPGIVAPAKPASLSWRGRPVWSFQALISEASDTTEEGSSSTPGSGRPASPPPFPHLPWKSLPIDQFGSNAMKPRDPTPAKKVQTTPFRVEIPSDAPVLKGDRVADFSPWTGNHPEDVLNDHSVKQGHYDRTQVSQNESNTARPSLYAQLKHRSGLQMLSSVFMAALEKRQSHNMVTAPSSFKPPPRVTLTDNKREAWLRDLANPSVPLRRLSRTIPHGIRGKALLDQCLNKWIPVSRAVWLAKCVGANEIRAFKRKGTSGTLALGLEAKWVREWTSGVQQFLEGVIGTCGSAEWKSKMTYAASLTARLFFERLLDYDQYFTWFLASLDSASLNMLPVWLLMLGIYWNSILRYRKRGRRLAELLLEKLQQIKDIRRPLLFQPLVDRLSCCIRKLVLEHTSSLILPSSWDTYKDLIRSCLHMKETADKAIFDALAERNVRVQLPKSRPESTQQSAQQRALHLFDSIHSSHDFPSTSMACLNSVEDKPALVAKLLEWSATPFRSGLCRIYTAARLLRKWKMSGVDIDSYIIMFLSNVEDTAQLNMDNVYHVISELVRSQTFSISKYLQWLMAKGVTKASRANNGEVMSSDVSLLTQLPMGRHPEHIRNLRQTLLSRAGLSLTDERSAIESWKSSISQRLPNIFPVKYSNAVPTSLSKLNPTWAVKSEVSMWVRQGVAKHTRDTARKIGGSSLSIDSRVSALTAGEFYCIREVLEDFGDLSILADVLKQATGCEDNMVLASATDTINYHFDAFCVIGATSDLFRGLIGSYARLKRYGTLNLEFVFSLIELGLRIPDESSTVALLRQDLARIESKSALAAPSPLSDHLPAAFCDVDASFQDKLDQLLSSGNGIDESSMATVFKSLTKILEYGSNLAKLSANDACRYLAYLRPFNPKYFDLMLVRWVCGLLRSTSRPVMSRILPPLIGVGCVTIQSFVSLVKKLLTSEKASPGIPELASLRLDLLQLLAPQEESNTDLVSYRFRMARQEFMIKYPEATLNIIDDAVPLLDFKLQGSNTGPLRGDLTECAATLLRTLLLQNSSLVTGYCMQKLTHHSQFTTVLEKAVDLLLGFDLQHRETESRSQARKVILVNNDFSLPFCQLKLQLLFNAKAGDEVRNNIVDVMFKAAVEDSRSKRSHWLGLVNLMSHDAARQIREQAENSFFSVPLFDEAGDASSASTATSSTNSIDNAKLYLTIIEKLAFSIPEAGVPSVVPHLVERFDLLLQKLIIMQTNLHSFSENRHGMSSGPAVMSRFNFERSLAFWFSALLRMTVLHRAAFTAQTSLAPKTGSLQEQTRLLVSIFCISLARLPDNILRLFPTANYFPHSAQPQNFRPCPGILLQTHALDVAASLIDSFPDEARHQCARFLKEKCPPFLQFQNDRRFLYLLGPVADGTTANPQLPASVSSPAAGGSTPTPTPSANLTGAPVNQSQPVAASASHFPGLSENVSSAADRLRIQHRGRIIGPYPVRPWELLEDAAPIMGVNDTAVSLKLFDTRRIRA
Length1595
PositionKinase
OrganismAspergillus calidoustus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Nidulantes.
Aromaticity0.08
Grand average of hydropathy-0.166
Instability index48.22
Isoelectric point9.20
Molecular weight176412.10
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05889
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     154.42|      39|      40|     332|     370|       1
---------------------------------------------------------------------------
  295-  328 (39.92/22.58)	.......REAWLRDLANPSvPLRRLSRTIPHGIRGKALLDQ
  332-  370 (63.82/41.03)	KWIP.VSRAVWLAKCVGAN.EIRAFKRKGTSGTLALGLEAK
  374-  408 (50.68/30.88)	EWTSgVQQ..FLEGVIGTC.GSAEWKSK...MTYAASLTAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.52|      23|     409|     170|     200|       2
---------------------------------------------------------------------------
   67-   89 (36.90/ 9.23)	QEREP.PAKRLKLDASAGSFPTDA
  173-  196 (35.63/26.78)	KPRDPtPAKKVQTTPFRVEIPSDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.38|      40|      52|     579|     630|       4
---------------------------------------------------------------------------
  579-  622 (58.88/71.47)	LNSVEDKPAL.VAKLLEWSATPFRSglcRIYTAARLLrKWKMS.GV
  632-  673 (59.50/36.42)	LSNVEDTAQLnMDNVYHVISELVRS...QTFSISKYL.QWLMAkGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.06|      30|      58|     884|     915|       5
---------------------------------------------------------------------------
  884-  915 (39.80/38.12)	LIELGLRIpDESStVALLRQDLARI.ESKSALA
  942-  972 (47.26/33.13)	LLSSGNGI.DESS.MATVFKSLTKIlEYGSNLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.41|      15|     309|     107|     122|       6
---------------------------------------------------------------------------
  107-  121 (29.13/17.51)	APAKP...ASLSWRGRPV
  147-  164 (26.28/ 8.98)	RPASPppfPHLPWKSLPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     354.06|     151|     470|     684|     883|       8
---------------------------------------------------------------------------
  707-  818 (88.66/137.89)	............................................................................LRQTLLSRAGLSltdERSAIESWKSSISQR...LP..........................................................................................................................................................................................................................................................................................................................................NIFPVKYSNAVPTSLSKLNPTWAvkSEVSMwVRQGVAKHTRDTARKiggsslsidsrvsaltagEFYCIReVLEDFGDLS
  819-  883 (66.30/28.60)	ILADVLKQATGCEDNMVlASATDTINYHFDAF...CVIGAT.....SDLFRGLIGSYARLKRYG.TLNLEFVFS...............................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1214- 1270 (53.55/21.31)	...............................................................................................................lielglripdesstvallrqdlariesksalaapsplsdhlpaafcdvdasfqdkldqllssgngidessmatvfksltkileygsnlaklsandacrylaylrpfnpkyfdlmlvrwvcgllrstsrpvmsrilppligvgcvtiqsfvslvkklltsekaspgipelaslrldllqllapqeesntdlvsyrfrmarqefmikypeatlniiddavplldfklqgsntgplrgdltecaatllrtlllqnsslvtgycmqklthhsqfttvlekavdlllgfdlqhretesrsqarkvilvnndfslpfcqlklqllfnakagdevrnNIVDVMFKAAVEDSRSK.RSHWL..GLVNL.MSHDAARQIREQAEN..................SFFSVP.LFDEAGDAS
 1288- 1414 (145.55/87.97)	YLTIIEKLAFSIPEAGV.PSVVPHLVERFDLLlqkLIIMQTnlhsfSENRHGMSSGPAVMSRFNfERSLAFWFSalLRMTVLHRAAFT...AQTSLAPKTGSLQEQtrlLV..........................................................................................................................................................................................................................................................................................................................................SIFCISLAR.LPDNILRLFPT...........................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.41|      23|     470|    1065|    1104|       9
---------------------------------------------------------------------------
 1082- 1104 (39.38/51.37)	RQEFMIKYPEATLNIIDDAVPLL
 1554- 1576 (43.03/18.67)	RGRIIGPYPVRPWELLEDAAPIM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05889 with Med12 domain of Kingdom Fungi
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