<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05881

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMRPRDTDRAAAATSQWKAFLDRCLMHRIDAAEFRDLSKLLRARCPIGDSSLIDLLLQTRLSTGVKWDPLLPLYIDCLCKRGGVQISTVLASLLRHSSILDKPSPGADVAAIKKRAKCYTLMTDIKVIQDAMLSISTGATVKSLLEAIQVFSATADWIQAIIAWHNSHLDADQPVGLMASPDAVLLYESLGFLLAALSGTQRGLEVLSSHSHDALKVRIGQALSAFLPLCAEVSLALRNRLDSVQKEFNLYGQPPSKLEVSMMDNVNVNALNFEASIIDGPTINSRAGLYVYINAMGHYEILIQEIITAAFDVLSNAMYRNESSRTMLLFRSFLVNKLPTFFAAMLSVSMVSLPMEVCIGHALSRLDPNTFPSFSQMFSMQGNSSLSDVRQEFLFSCASHKLIPESSIERLLGENPMQTLPVGGPLVKDDLVAQISANHERAEQLISDIESTEGNAAAIVGAITEVMHNLCNQKETMTLKNICNSLSRRPQSLDVMLLFRSPKQILQPLCALLDSWHWDEDQAESQPVYDEFGSILLLVLTFKYRYDLRPFDLGITSSNSFILKLIERGSSSLKLEELSEKQNKNIGEWIAALFIAEGISEETMSGCSPQEFYMLVSTLFRQSLGACEAGKLEFDTLKGGFEYLLEPFLLPSLVVALTWLSNHIWESEQDPTIPLKTLQSLVSPSSISGEAREIHLTVLNITARALEEQLKDVRARHPNRTDIKPILDALEPCLSFKRTASCHKSELESWTTHSPGGLLGSIRSTFQSLVIWSTSPDVNMAPPSYTHRQIISAIRMLGATRVLTSLLEELKLQSQSGNADLALDIAATLICTPLAESYAIDQNTHHPVDPTKEPVPRCPMLTLRDALNLHHADVPKISEKDPLRAELVVRLYRRVNVLLAPPAQVTNLDMNMNMNMNSIIQNMQLGVDQTSMDLDPSGASSAPGQNEQANLDQIMDNAAAAVGMDMDGGQGMDDLGLGSSTGLDQSIDDVLNAAEMNPEFLDLDMEGMF
Length1008
PositionTail
OrganismAspergillus calidoustus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Nidulantes.
Aromaticity0.06
Grand average of hydropathy-0.013
Instability index47.87
Isoelectric point5.04
Molecular weight111002.18
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05881
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.01|      32|      50|      15|      53|       1
---------------------------------------------------------------------------
   15-   53 (47.19/53.08)	QWKAFL....DrCLMHRIDAAEFRDLSKLLRarcpigDSSLID
   65-  100 (52.82/36.21)	KWDPLLplyiD.CLCKRGGVQISTVLASLLR......HSSILD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.56|      10|     179|     120|     131|       2
---------------------------------------------------------------------------
  122-  131 (18.92/14.27)	TDIKVIQDAM
  720-  729 (18.64/ 6.09)	TDIKPILDAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.86|      14|      48|     353|     371|       3
---------------------------------------------------------------------------
  214-  227 (24.57/ 8.08)	LKVRIGQALSAFLP
  354-  367 (27.29/18.68)	MEVCIGHALSRLDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.96|      13|     166|     319|     331|       4
---------------------------------------------------------------------------
  319-  331 (24.24/14.26)	RNESSRTMLLFRS
  488-  500 (24.72/14.68)	RPQSLDVMLLFRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.25|      46|     500|     156|     204|       7
---------------------------------------------------------------------------
  156-  204 (68.07/50.85)	WIQAIIaWhNSHLDADQPVGL...MASPDAVlLYESLGFLLAALSGTQRGLE
  658-  706 (75.18/43.11)	WLSNHI.W.ESEQDPTIPLKTlqsLVSPSSI.SGEAREIHLTVLNITARALE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     150.91|      46|      54|     902|     951|       8
---------------------------------------------------------------------------
  902-  951 (71.31/51.81)	AQVTNLDMNMNMNMNSIIQNMQLGVDQtSMDLDPSGASSAPgqnEQANLD
  958- 1003 (79.60/45.86)	AAAVGMDMDGGQGMDDLGLGSSTGLDQ.SIDDVLNAAEMNP...EFLDLD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05881 with Med5 domain of Kingdom Fungi
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