<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05875

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGIVMEQNNIGGRGPDLRDQMNGISSTSLNTGQPEHTAEAPNGLLYTNGIRANNADQNDGASRSKIFSSAAREPPELEHITQGFFPFSKLVNRAVQQCWNDLSEMVAELAEIQISSQEPINSLLSTSGKPPGNQSPENVRKKLRALEFAQNKRGDFIKLLVLSQWSRQAADVSKLIDIQNFIRAQHQAYAGALQWMGDMKRDLVRAQVANPDLRTALEVLSKGEIVSMPDLGYGTPKPLTPKTTLRKLRKINRIISARLALHENIPLPFQQYRVHDGRVTFVVPGEFELDLSIGEEDVISQFFFVDIRLLFKPSSSIPANRMFSELDLKINNTLRNSGLIGCFDWLHSLVLTNKINILTKQAADLARGLWSNVLRIELLHRTLVLQYWASKPGSKSWLEIGIQRRGRIGSTNGQQSPSLGLRWMRDGQEIPSGDIEFDKNNLSAERLLRSVISLHISHILSSVFANISGKELYSSGTLSLRAHLSKTEPGDCQLNVQLTASRRLRVAIEPMSGAIILAATPNTLERIDTDRNVDRPTIDDIVARVGRLRCAAAIEEVESKVKMLGFESLSPKKVKVDPRRIFSASVLRFSFFGHRLWERDWVLAATSSMDGDNWWVVQATTQVDPIGSTAQAICSALLPLRDTGYSSLADLGHCLSGTLAIYAIARFLESLQVVRFFPPLEKLKFGSSLQVPDLMIRYEASELPEALQMAVPSGFRKKTFIKNTVRLSFHGVDRHSDASMMVVYGNLCTPSRSFSALIPKDDLSLAFPKAGTGFALRLLASPGYPIILTLLERLQRLECVLSIYETLQRKRIETRSLSLSRVDFTYGPNRDLSARLDISTSGPLPSTELDPVRIASKTNRLFQLRLGIQFNHLNPHRRIQGPLASNLNRPSADAGLDTMVELLSFTLPLMRALDKIMANPTKNEPLKLHVIVRTAKSFQLHYPLEDCRFQLIAHQHQSRPVWVFKDISTAQNTAGGNSTSQKLQDSLYNSKGDGWRGLGNGIVAEPDRVGNLLEDLDKCLALIRADLALKSSDTKPSHEAPPATNDQPHIKAQQPKQAEANQGPGNRNAPQKSDIIMID
Length1080
PositionTail
OrganismAspergillus calidoustus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Nidulantes.
Aromaticity0.06
Grand average of hydropathy-0.264
Instability index40.19
Isoelectric point9.31
Molecular weight120023.05
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05875
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      68.07|      15|      15|     668|     682|       1
---------------------------------------------------------------------------
  668-  682 (25.75/15.38)	FLESLQ..VVRFFPPLE
  686-  700 (24.53/14.30)	FGSSLQ..VPDLMIRYE
  704-  720 (17.79/ 8.30)	LPEALQmaVPSGFRKKT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.27|      32|      32|     905|     936|       2
---------------------------------------------------------------------------
  905-  936 (53.90/40.44)	SFTL..PLMRALDKIMANPTKNEPLKLHVIVRTA
  938-  971 (53.37/39.96)	SFQLhyPLEDCRFQLIAHQHQSRPVWVFKDISTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     138.72|      31|      67|      88|     118|       3
---------------------------------------------------------------------------
   52-   83 (23.45/10.55)	......RANNADQNDgasrskiFSSAA.REPPELE..HITQ
   88-  118 (50.15/31.44)	FSKLVNRAVQQCWND.......LSEMV.AELAEIQ..ISSQ
  121-  149 (29.95/15.63)	INSLLSTSGKPPGNQ.......SPENVrKKLRALE..F...
  157-  186 (35.17/19.72)	FIKLL...VLSQWSR.......QAADV.SKLIDIQnfIRAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.79|      23|      39|     476|     498|       5
---------------------------------------------------------------------------
  476-  498 (38.94/26.88)	SGTLSLRAHLSKTEPGDCQLNVQ
  513-  535 (36.85/25.02)	SGAIILAATPNTLERIDTDRNVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.03|      30|      39|     809|     847|       6
---------------------------------------------------------------------------
  809-  847 (43.03/45.54)	QRKRIETRS.....LSLSrVDFTY.GPNRDLSarldistsGPLPS
  851-  886 (44.00/26.02)	DPVRIASKTnrlfqLRLG.IQFNHlNPHRRIQ........GPLAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.13|      17|      66|     373|     401|      10
---------------------------------------------------------------------------
  333-  356 (24.61/11.70)	NTLRnsgligcFDWLH.SLVL...TNK........I
  373-  401 (11.52/34.09)	NVLR.......IELLHrTLVLqywASKpgskswleI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05875 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KSSDTKPSHEAPPATNDQPHIKAQQPKQAEANQGPGNRNAPQKSDIIMID
2) MPGIVMEQNNIGGRGPDLRDQMNGISSTSLNTGQPEHTAEAPNGLLYTNGIRANNADQNDGASRSKIFSSAARE
1031
1
1080
74










Molecular Recognition Features






MoRF SequenceStartStop




1) APQKSDIIMID
2) HIKAQQPKQAE
1070
1050
1080
1060