<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05874

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSDRASSAALRAGPPSPSSPAPFFYNKDSVPHIPASDQIPQTPTSPPLMSVSAPNNASNFTSLQAVPSQATSQPASISSPPSSAPMSTQNSQQPTVGVTNSFPTPASSVDPDHIDKSFGAGISETPAPSAAGASAGSAQQSEYRRTDHDRNFGTAQTGTGIRDFADCNTNKPDAMDVDTELSAHTNPGWPSLDSLQKDFSSAFHLCKSSHIATGPDPTVDLISLYGLGPVAKSVARNDPITGEKINRLRKSYEGKLKGLGLAGRNKPVKHDPATPGGLRQMTMWPEEEWQNQKVFGKEIKVADLDSALHDLQMKAMKMEPGTVPNNDYWEDVLGHDKPSKHANTGDAIKKAAAPANSGGRPIGQPNGTPTAAEPERGRPSRGRKRHYDDNSFVGYGEGYADDDEDAAFYSNSEGTGKKKRKKDHVSKISTPLPDRGGSYGVGMFGIGAR
Length449
PositionHead
OrganismAspergillus calidoustus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Nidulantes.
Aromaticity0.06
Grand average of hydropathy-0.779
Instability index47.27
Isoelectric point6.64
Molecular weight47560.86
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05874
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     146.89|      30|      31|      52|      81|       1
---------------------------------------------------------------------------
   18-   45 (30.74/10.60)	.......SSP..APFFYNKDSVPHiPASDQiPQTPTS
   46-   79 (46.62/19.79)	PP.lmsvSAPNNASNFTSLQAVPS.QATSQ.PASISS
   80-  108 (42.23/17.25)	PP....sSAPMSTQN..SQQPTVG.VTNSF.PTPASS
  110-  141 (27.30/ 8.61)	DPdhidkSFGAGISETPAPSAAGA.SAGSA.QQS...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     253.20|      84|      93|     184|     275|       2
---------------------------------------------------------------------------
  158-  238 (81.23/45.86)	....................GTGIrdfadCNT.NKPDAMDVDTElsaHTNPGWPSLD.SLQKDFSsafhlcKSSHIATGPDPTVDL.ISLYGLGPvaKSVARND
  239-  327 (130.74/56.73)	PITG.EKINRLRKSYEGKLKGLGL.....AGR.NKPVKHDPATPgglRQMTMWPEEEwQNQKVFG......KEIKVADLDSALHDLqMKAMKMEP..GTVPNND
  331-  380 (41.23/12.14)	DVLGhDKPSKHANTGDAIKKAAAP.....ANSgGRPIGQPNGTPtaaEPERGRPS.................................................
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05874 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DEDAAFYSNSEGTGKKKRKKDHVSKISTPLPDRGGSYGVGMF
2) DLQMKAMKMEPGTVPNNDYWEDVLGHDKPSKHANTGDAIKKAAAPANSGGRPIGQPNGTPTAAEPERGRPSRGRKRHYDDNSFVGYG
3) LGLAGRNKPVKHDPATPGGLRQMTMWPEEEWQ
4) MSDRASSAALRAGPPSPSSPAPFFYNKDSVPHIPASDQIPQTPTSPPLMSVSAPNNASNFTSLQAVPSQATSQPASISSPPSSAPMSTQNSQQPTVGVTNSFPTPASSVDPDHIDKSFGAGISETPAPSAAGASAGSAQQSEYRRTDHDRNFGTAQTGTGIRDFADCNTNKPDAMDVDTELSAHTNPGWPSLD
403
310
259
1
444
396
290
193










Molecular Recognition Features






MoRF SequenceStartStop




1) PFFYNKD
2) RKKDHVSKIS
22
420
28
429