Description | Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MAAVNEGQIKVLEQTRQRLLQLTHSLGSLTGSLQQSDPLPSWSSLQSQASIISNNLVNISTQISEHHELLSSLVAYPAPSFPGTTQQAVLEQLLRTKLDPRVQDWVEKGLKAGTKSADETRGLSEAELEELWAWAPIEANQEARRRNWGGNYTLEEREAGIQNVVTGLSRQLEDDESEESDEEEDDEDADDDKMEIVGVNRRPGASGVEFDSTSEKHRGPTAASPAMPLTDVFRYMMTGTRPGK |
Length | 244 |
Position | Head |
Organism | Talaromyces islandicus (Penicillium islandicum) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Islandici. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.709 |
Instability index | 59.10 |
Isoelectric point | 4.57 |
Molecular weight | 26958.34 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP05870 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 46.76| 12| 37| 38| 49| 1 --------------------------------------------------------------------------- 38- 49 (23.20/11.99) PLPSWSSLQSQA 77- 88 (23.56/12.27) PAPSFPGTTQQA --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) AMPLTDVFRYMMTGTRP 2) MEIVGVNRRPG | 226 194 | 242 204 |
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