<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05869

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMEQASALTLPLRPQVDKGAKKDSLPIRIAQINAQRGSFRNITEQSLQDEIEALKEKRKGAKASEGEEEEEEDVEEKPAEFDDTERQELLYKRRAEIAQFAAQAHMEVQFALDFVSLLLSKYAPRQAEQTISPYLKQNVPTGSLNVDVVRAPQKSESAQRDAQTVARGWKLESYSSAANKLLKAGSRLENEVSAETKYWDQVLSIKEKGWKVCRLPRERQALGVQYGFLEATPVFRDRGLASLRRADDGTLILDKGLVPSRPKAVRVRVRREGKITGSSGLSQFVAAAAVDDSIEKTILQARDTLFEEELFHELNREARSLASSGVIAHRNLIEFVYDEGQQIILDLVDLDDMPSETETIEPDPQCGAIAEATAHALRILLSYAHRQNLRRRSQFPPPLTNHKRPTPQYQLLRPILAYLQHNSHLRSLQVFMDDTYKVLKSAGLFSEYTSSVFSALKPSASPDLSTVETLVSQFLEPFESRFSGAMANPTSTFNIRMYTSMPDANRPTAIGTEYDLSIRLPDFPHTQPPSRIGLKNEVESFLLHLLTLDLTTYFTSISSQIAAEQASSSSAAAADSSSSGPSLLSWESPFPHYGELIGCKQDGTIAKQLWIEIKRDALSLRMVSKEETDPDTDTDIGFDIVDGEGGLKYTQPPKRLARGNLIHVWKCGGGEGSEQKTLKEVIGELSKYE
Length688
PositionHead
OrganismTalaromyces islandicus (Penicillium islandicum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Islandici.
Aromaticity0.07
Grand average of hydropathy-0.484
Instability index56.23
Isoelectric point5.52
Molecular weight76701.47
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05869
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     277.80|      90|     123|     434|     535|       2
---------------------------------------------------------------------------
  434-  535 (144.52/99.54)	TYKVLKSAGLFSEYTSSVFSALKPSAS..PDLSTVETLVSQFLEPFESRFSGAMAN......PTSTFNIRMYTS.MPDANRPTAIGteYDlsirlpdfphTQPPSRIGLKN
  551-  659 (133.28/85.92)	TYFTSISSQIAAEQASSSSAAAADSSSsgPSLLSWESPFPHYGELIGCKQDGTIAKqlwieiKRDALSLRMVSKeETDPDTDTDIG..FDivdgegglkyTQPPKRLARGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.70|      37|      42|     238|     279|       3
---------------------------------------------------------------------------
  240-  279 (55.49/49.95)	ASLRRA...DDGtliLDKGLVPSR....PKAVRVRVRREGKITGSSG
  281-  324 (48.21/28.39)	SQFVAAaavDDS...IEKTILQARdtlfEEELFHELNREARSLASSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.58|      14|      33|     376|     389|       4
---------------------------------------------------------------------------
  376-  389 (25.15/15.54)	LRILLSY.AHRQNLR
  411-  425 (22.44/13.13)	LRPILAYlQHNSHLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.28|      12|      40|     353|     364|       7
---------------------------------------------------------------------------
  353-  364 (22.74/13.39)	PSETETIEPDPQ
  396-  407 (24.54/15.00)	PPLTNHKRPTPQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05869 with Med17 domain of Kingdom Fungi
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