<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05864

Description Positive regulator of purine utilization
SequenceMGEHKPRPGSRPVFTDPWKPSAPLKVIQDAPDGRIAHTLTACTRCRQRKSRCDPGIPRCEPCQRSNSRCVYYDPARNMPIPRTYIVQLQEKARALEHEIQEAEKEVQHAADAELMARGAGRIKFTPTDEPRYLGPSSGIAITRLVMELAKQNTDSKSIKDVVPEMTAQEIRDMFTKESSKPTSKVYPMISSMPQEELPPRELTYKLIDLYMVRGQAMLPVLHEPTFRQAAEDVFAGSNDPVKNFELRMVIAISMQKLSADYAGLADSYYLAALPFLEPSIKLMNIKSLQCLALIAQYSLVTPTRTASYWVVGVAVKLAQELGLTEEATITKSPTGEPLNVLEVDVRRRVAWVIITMEFGLSHSLGRPNSFCVSHDHLDINFPELVDDRYITPQGILPGAKPILAKCIAIHFFKMRLLQAEARRVLYLNKRETPVDHQDPWFEQFVAKLDHWVASCPKHDGGSGLSETWFIGRKNTIVVLLYRPSPQIPEPLADAARKCYDACVFNVAMHREQMTTGSVDLTWASTQALFMAISTLLWTLSYPEIRQEHPIDEVKNYLQIALEGVMISAQRWPGCESALHLYQSLISACLKAYGTNDSFVVHSPSTHPSPVSTHDAATPPTMSSPSVNSNYSSQTITSASHLVSDADIKTSLSREHTPTYSPVQNIAVPTSQSPLKQSDIPPTTSAPLPQSLPVQPPALNHPLYDTRQPYAPMTANYCDPNFDAGTPFNPFPSVVPGLPGWDPNYTAASTREGSLSYVGANVDPMFWMGTFGDQYSQYSNQPGPWRGRTLSQEEQVELMDSLADNIPDVSSLLVNHGTVSARERSLDRPTLVIRSLVTLRSTQSSFVLLKKVVTKTVVSVLTDLLSSSCDFMSASLPPPSSHLPSPSSSSGDHFKANRSPQRSHTLDPHTPTSPPLMSVGAQSYAANLANPHTSPSHTTSNGQPLSSPSSTPMSTQTSQQPTVSATNSFPTPASSISGHQRNATPAEDSEAADKLWAQGTQHSTTDMMDIDKTEHRRSDHDRDQIPGATDVGGLPTSAAADMMDIDSKAPRLIADDPSIDALQKDLGTAFHLCKTAPTITGPDPSLDLISLYGLGPIGRSVMRADPITGEKINRLRKSYEGKLKGLGLAGRNKAVKNESPAGGLRALMMWPEEEWRNQKVHGKEIKVADVDSALHKLQTRAMKMEPGSLPNNDYWEDVLGHEKPSKHINVDGGKRSVSTPNPNRPAVQVNGVGAPAATEPERARPTRGKKRHYDDNSFVGYGEGYVDDEDESAFYSNGEDRSGKKKRKKVDFF
Length1292
PositionHead
OrganismTalaromyces islandicus (Penicillium islandicum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Islandici.
Aromaticity0.07
Grand average of hydropathy-0.465
Instability index49.61
Isoelectric point6.52
Molecular weight142108.04
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
DNA binding	GO:0003677	IEA:UniProtKB-KW
DNA-binding transcription factor activity, RNA polymerase II-specific	GO:0000981	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro
zinc ion binding	GO:0008270	IEA:InterPro

GO - Biological Process
transcription, DNA-templated	GO:0006351	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05864
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     134.44|      29|      32|     636|     666|       1
---------------------------------------------------------------------------
  636-  666 (40.90/25.57)	TSASHLvSDADIKTSLSrEHTPTYSPVQNIA
  669-  697 (55.07/26.81)	TSQSPL.KQSDIPPTTS.APLPQSLPVQPPA
  932-  952 (38.47/16.38)	TSPSH.........TTS.NGQPLSSPSSTPM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     108.82|      26|      26|    1055|    1080|       2
---------------------------------------------------------------------------
 1055- 1080 (46.37/26.66)	DPSIDALQ.KDLGTAFH..LCKTAPTITG
 1082- 1108 (43.49/24.56)	DPSLDLISlYGLGPIGR..SVMRADPITG
 1123- 1142 (18.97/ 6.73)	.........KGLGLAGRnkAVKNESPAGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.62|      20|      33|     978|    1010|       3
---------------------------------------------------------------------------
  978- 1010 (31.03/43.64)	HQRNATP.AED......SEAADklwaqgtqhsttdMMDID
 1019- 1045 (29.59/15.29)	HDRDQIPgATDvgglptSAAAD.............MMDID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.45|      12|      15|     701|     712|       4
---------------------------------------------------------------------------
  701-  712 (25.21/13.02)	PLYDTRQPYAPM
  719-  730 (24.24/12.21)	PNFDAGTPFNPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     109.19|      21|      21|     865|     885|       5
---------------------------------------------------------------------------
  865-  885 (39.85/22.60)	SSSCDFMSASLPPPSSHLPSP
  887-  907 (36.23/19.77)	SSSGDHFKANRSPQRSHTLDP
  910-  930 (33.12/17.33)	PTSPPLMSVGAQSYAANLANP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.58|      25|      41|    1154|    1178|       6
---------------------------------------------------------------------------
 1154- 1178 (42.48/26.50)	WRNQKVHGKEIKVADVDSALHKLQT
 1194- 1218 (44.10/27.78)	WEDVLGHEKPSKHINVDGGKRSVST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.05|      13|      15|      39|      51|       9
---------------------------------------------------------------------------
   39-   51 (24.02/15.26)	LTACTRCRQRKSR
   56-   68 (26.03/17.22)	IPRCEPCQRSNSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.41|      22|     419|      12|      33|      11
---------------------------------------------------------------------------
   12-   33 (44.33/29.29)	PV.FTDPW..KPSAPL.KVIQDAP..DG
  433-  460 (29.08/16.19)	PVdHQDPWfeQFVAKLdHWVASCPkhDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.36|      33|     313|     192|     256|      14
---------------------------------------------------------------------------
  217-  256 (44.78/74.02)	MLPVLHEPTFRQaAEDVfagsnDPVKNFeLRMV...IAISMQK
  535-  570 (54.59/20.17)	LLWTLSYPEIRQ.EHPI.....DEVKNY.LQIAlegVMISAQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.15|      15|      21|     756|     776|      17
---------------------------------------------------------------------------
  762-  776 (31.64/23.03)	DPMFWMGTFGDQYSQ
  780-  794 (29.51/ 9.33)	QPGPWRGRTLSQEEQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05864 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FMSASLPPPSSHLPSPSSSSGDHFKANRSPQRSHTLDPHTPTSPPLMSVGAQSYAANLANPHTSPSHTTSNGQPLSSPSSTPMSTQTSQQPTVSATNSFPTPASSISGHQRNATPAEDSEAADKLWAQGTQHSTTDMMDIDKTEHRRSDHDRDQIPGATDVGGLPTSAAADMMDIDSKAPRLIADDPS
2) HKLQTRAMKMEPGSLPNNDYWEDVLGHEKPSKHINVDGGKRSVSTPNPNRPAVQVNGVGAPAATEPERARPTRGKKRHYDDNSFVGYG
3) MGEHKPRPGSRPVFTDPWKPSAPLKVIQDA
4) VHSPSTHPSPVSTHDAATPPTMSSPSVNSNY
5) VSDADIKTSLSREHTPTYSPVQNIAVPTSQSPLKQSDIPPTTSAPLPQSLPVQPPALNHPLYDT
870
1174
1
600
642
1057
1261
30
630
705










Molecular Recognition Features






MoRF SequenceStartStop




1) GKKKRKKVDFF
2) YGEGYVDDE
1282
1260
1292
1268