<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05861

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMAAPIDQWRKLVRECLARRIDVAEFCKLVKLLAKRALLPEASLVDVILESRTVTNGQYDPLIPLYIDALTKIGKAKIAPVLNGLRRHSSIGEYAQSADENKQKTTAKLSTLMTDTRIVQDAIVPLSTPGLSLSTREVISIFIEASEWILALVRAHTSSLAEDQQSGGLLNLPDALALFESLGIMLIALSATEKGPDALSSDLSQGFKIPLGHALTAYLSSSAMISMNLRTRLDNLQKMYQLYGEPAPKDLDAQMMDGMNMSALQFEASVIDGPVINSRAGLYVYINAMLVGRPLVDDNMLLNYLSNRYGGHYEMPVQELITATFDVLSNGMYRNESGRNMFVFRSFLVNKLPPFLASMAATSMDPIPMEMCISHALNRVDPNAFPSFSQMFEMQGNTVLSDVRQEFLFSCALHRLIPESSVERLLGENPMQTLPVGGRYVKDEIAAQIHSNQERADQLISEIESLEGNAGAIVAAVTDVIHTLCHQRETVTLKGICNSISRRPQVLDVMLLFRSLKAILQPVCSLIDAWKWDEDQGENQPVYDEFSSILHLILAFKYRYDLNQYDLGISNPQSFVLKLLDQGSTSLKLDDLSEKQHKNLGAWISALFIAEGISEDTMSSCSPQEFYMLVATLFSQTLGACELGKLELDTLKGGFEYLLEPFLLPSLVFALSWLGGYIWESESNPSIPLKVLYALIKPNSISGEAEAVHRSVLNISARALEEQLKDVRARHPGRTDIKPILDALEPYLSFQRNGSSRRSELDSWTSHSGGLSSCIRSTFHGLVLWSASPDMSMSPPSYTHRQVLAGIRLLTASRVLPVLLDELKSQAEAGTLDLALDVAATLICAPMPESFALEQAMYHPVDTNKEGLPRCAILTLRDALLLQHETVPKLSEKDPVRAEIIVRLTRRVNSLLALPAHITNLDVSNIMQDINLDAAAQEPMNLDGSGGGGGGGGNGDGTDGGGAGGASNENIEQILNDAVAANGTGLGLGLDDGTGMDTSLEDMFDAANMGNPELLTDLDMEGMF
Length1023
PositionTail
OrganismTalaromyces islandicus (Penicillium islandicum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Islandici.
Aromaticity0.06
Grand average of hydropathy-0.017
Instability index46.10
Isoelectric point4.87
Molecular weight111794.70
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05861
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.51|      12|      15|     942|     953|       1
---------------------------------------------------------------------------
  942-  953 (25.06/12.18)	DGSGGGGGGGGN
  958-  969 (23.46/10.99)	DGGGAGGASNEN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.91|      14|      15|       5|      19|       2
---------------------------------------------------------------------------
    5-   19 (22.30/22.04)	IDQWRKLVReCLARR
   22-   35 (23.60/17.10)	VAEFCKLVK.LLAKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.01|      14|      19|     754|     771|       3
---------------------------------------------------------------------------
  757-  771 (22.44/20.34)	RSELDS...WtSHSGGLS
  775-  791 (23.56/ 7.82)	RSTFHGlvlW.SASPDMS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.00|      11|      19|     357|     367|       7
---------------------------------------------------------------------------
  357-  367 (21.16/11.50)	SMAATSMDP..IP
  373-  385 (16.84/ 7.78)	SHALNRVDPnaFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.29|      14|      19|     606|     620|       8
---------------------------------------------------------------------------
  606-  620 (20.08/15.50)	LFIAEGISEdTMSSC
  627-  640 (24.20/13.58)	MLVATLFSQ.TLGAC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.10|      20|      21|     650|     670|      11
---------------------------------------------------------------------------
  650-  670 (30.81/23.16)	LkGGF..EYLLEPFLLPSLVFAL
  673-  694 (30.29/17.70)	L.GGYiwESESNPSIPLKVLYAL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05861 with Med5 domain of Kingdom Fungi
Unable to open file!