<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05860

Description Bifunctional polynucleotide phosphatase/kinase
SequenceMHELLLFASVPANQHYELLQQLAGLAAMQPRHRIERRLVFKASRKTGRINTRLGGGTQDVQGAELQRLTKMLTGATYYTHAVGLVRESDFGAAAVAETTAPDDDKAYDFENQLWRMEWRDIPEAGTRSAVTSRLMANALLPQGDVVTTMNSWGYEYISTLFVTEYVIEGDVFVYNDTTLFLHRILNFAHDASSSPSSPRRTLPPLKELSLLDPSGSYLLQAAVTVQDGSNPGMVKTATQHLFGLKEQLKTAVKLEQADPEQNLKTLLDIFQERWIYQDEKANKCYDFLREDLVWQYKPIVDRDPVKILTLRAVIDESIQRPEKALTCETLKPRPIFFDIKTTPVSHIFPCEIQWMIIDLLGYKEIPKLLRAFGWVLSDSYWSRRLPRDLKFELDDLDNVEIDWQFLTLGVEKLLQRSYGLLNRRRLLPVDRRGVGDMKRSSSLAGAVSPPPLKRKVESTTTKSSVASFFTPTSQKKPEKVTWRIVNKSLIVGKYASEPGTSEKFESGMRRRVAAFDFDSTLISTASGNRFARDAKDWKWWNGKVPERLKQLNSEGYQVVVLSNQKKISLQSDNIKSGRTESKSLATFKEKVSAVMRQLDIPLSIYAATQADEYRKPRTGMWKELMDDYDLDLDGRLDLKGSFFVGDAAGRPADHSCSDRDFASNVGLDFKTPEEFFLGAKPEQVIRKFDPMSYINGDPDAAVTPTFSKLHSLELVIFCGSPGAGKSTFYWKYLQPLGYERVNQDILKSRPKCIKVAKEHLTAGNSVVVDNTNAGAETRAYWTQIAQEFKIPIRCIYFTSPPALCKHNDAVRAANPLLNPESRASLPGIAFGDFARRFQEPQLSEGFEDITKVDFTFEGDEEAKNVWSRFWV
Length871
PositionHead
OrganismTalaromyces islandicus (Penicillium islandicum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Islandici.
Aromaticity0.10
Grand average of hydropathy-0.409
Instability index39.51
Isoelectric point8.32
Molecular weight98688.19
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
kinase activity	GO:0016301	IEA:UniProtKB-KW
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05860
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      68.12|      16|      17|     354|     370|       1
---------------------------------------------------------------------------
  354-  370 (25.47/20.47)	WMIIDLlGYKEIPKLLR
  374-  387 (26.76/16.35)	WVLSD..SYWS.RRLPR
  403-  414 (15.89/ 6.68)	WQFLTL....GVEKLL.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.06|      48|     176|     296|     345|       4
---------------------------------------------------------------------------
  296-  345 (74.40/54.93)	YKPIVDRDPVKIlTLRaVIDESI......QRPEKALTCET.LKPRPIFFDIKTTPVS
  469-  523 (71.66/44.43)	FTPTSQKKPEKV.TWR.IVNKSLivgkyaSEPGTSEKFESgMRRRVAAFDFDSTLIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     404.81|     128|     184|     542|     674|       5
---------------------------------------------------------------------------
  542-  674 (202.18/150.11)	GKVPERLKQLNSEGYQVV...VLSNQKK.ISLQSDNIKSGRT....ESKSLATFKEKVSAVMRQLDIPLSIYAATQADEYRKPRTGMWKElmdDYDLDLDGRLDLKGSFFvGDAAGRPADHSCSD..RDFaSNVGLDFKTPEE
  724-  861 (202.63/134.42)	GKSTFYWKYLQPLGYERVnqdILKSRPKcIKVAKEHLTAGNSvvvdNTNAGAETRAYWTQIAQEFKIPIRCIYFTSPPALCKHNDAVRAA...NPLLNPESRASLPGIAF.GDFARRFQEPQLSEgfEDI.TKVDFTFEGDEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.55|      17|      20|     428|     444|       6
---------------------------------------------------------------------------
  428-  444 (28.84/19.82)	PVDRRGVGDMKRSSSLA
  450-  466 (25.71/16.82)	PPLKRKVESTTTKSSVA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.49|      11|     177|     104|     114|       8
---------------------------------------------------------------------------
  104-  114 (23.06/14.17)	DKAYDF..ENQLW
  282-  294 (19.43/10.84)	NKCYDFlrEDLVW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05860 with Med18 domain of Kingdom Fungi
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