<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05858

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEFPGDAITNISVINGFSVIYWRIYNEETSISTQASETVASNGYSILKLLSRLKDLEIKLRNLGCHVSYYPRRLGLWIFSSTPGFESVDSFAQESPNQDLNAPERLIIGGTSLKVSASGSVTATDLIRSLSADPSSNSSGRTNYPVIYASFVSAIAGLVSLQLTRRLDAIPLGARTLFTPIERSFFSGPTIADSNANALPALTTLRIELSLTGKAIVSLNTVYQDGISRLGGYDITDVNPVDMRPNTDIWLAPNGTVARLIAFNAEKSNVFAERQKSDVTTRQFVESRQMLWKDTVVEWMRDIGLTVSSPEEEHWVEVEVSEPFYARFAADYLRQLDDIQSVSPLKRILWPSRFCFKRAKITSASLIDDIDSLVTDCDDPVNFAENWIGTAGARQGKPVPSTSHMQQTPQNKESSTPRIDFPEQIESLARVAQYPDLQSASTVYPTPPDGALVSAMNQTASDAFGSDGHDISMSRPTGDGIYPRRGVQIARNPGDATASRVKNESEVATGLYDTNGDEDLFGDIDDKAFGPKGITDDDFNFFDDPEIDDFDMGKDFDMEKPIAEPTQETPQQPQQPQLETVDIQTPQAGVSIENPQDEVIMQPSVNPDPQGDQGPGSVLNVEKIETNEHQNIATATPHGKYWNLPEQAMSPPLSPIEVKKILFSTADTDTTDANKDTKLIDLDADKKQSRYDSISFQQGLTMSDQKYSSSGHFFFAAQKRDIATANPSSEIPLVGFPRGRKPTHTHQPEKLNGTQQSPSATRIPRSTSVSSSETSFDSSDDDYERESSPARLATLKRKRPLSEAERSTTSSLERLSIASETDTHFTREDCSVFLGNFFSITTDWSLAGYFAFKQNHYSPVLIRKEDHVQLAQLMVDQLAQSSLSHKIDGCKPTPDLENDTVTLHTPLDDTSVLGENERLDLKTLVSLHDNMQMTMETPSARPNMQRKDVKGSITKISLPHLHVHRGKDYLDILPSSMSFWETFGLEPANGPKDISAYCIYPHFATEAADAFMTRLGLVYSGCSFGQHVRGDRYKPFENGLGAWSIAKGDGAYMRTMQSLKNLCESLGAALSKVPAVKENFVIYVINPFTHGAAFADISAAFLHLFHKYIGDVDRNYAKSQMNELVLQIIPMNFVYSPTSLAVPTQWQYLNLALEVYGRCPPKDASDGITGYAPPIVLADAAPKSLPFRVTSERVSPFQEGRCLHLAISRSVDQRWISAAWSDSSGSFQILMSYCLRARGSNVNRTLSEVRQEIWETTKDIMERTQTRSKVFLVRTEPIDQEEAEAWNGLAARYNQSKAMPVELTLLSVNITPGLHLQLPAAPISTNMINPPASTPVATPYGGVSSPDQFGVGTPASGGQGPMNAVTPTDLSASAEPDSDALLIDAHDESWAVILSHRLNNSTYITEYRPALVSGYLLRRKGVNDSQGVAAMSVSLIHTSRPSGAYETVLREALNSYRDLATLARAKGTLAVQHNTLPWHIATAVKGQEFLSYVF
Length1494
PositionKinase
OrganismTalaromyces islandicus (Penicillium islandicum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Islandici.
Aromaticity0.08
Grand average of hydropathy-0.374
Instability index43.14
Isoelectric point5.13
Molecular weight164505.23
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05858
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     998.10|     265|     472|     263|     539|       1
---------------------------------------------------------------------------
  263-  539 (431.28/307.46)	FNAEKSNVFAERQKSDVTTRQFVESRQMLwKDTVVEWMRDIGLTVSSPEEEHWVEVEVSEPFYARFAADYLRQ.....LDDIQSVSPLKRILWPSRFCFKRAKITSaslIDDIDSLVT..DCDDPV.NF...AENW..IGTAGARQGKPVP....STSHM.......QQTPQNKESSTPRIDFPEQIESLARvaqyPDLQSASTVYPTPP.DGALVSAMNQTAS.DAFGS..DGHDISMSRPTGDGIYPRRGVQIA..............RNPGD.........ATASRVkneSEVAT.GLYDTNGDEDLFgDID.DKAFGPKGITD..DDF
  542-  693 (215.10/132.86)	FDDPE........................................................................................................IDDFD.MGK..DFDMEK.PI...AEPT..QETPQQPQ.QPQL....ETVDI........QTPQAGVS....IENP.QDEVIMQ....P......SVNPDPQgDQGPGSVLNVEKI.ET..N..EHQNIATATPHGK..YWNLPEQAM..............SPPLSpievkkilfSTAD.........T.DTTDANKDTKLI.DLDaDK....KQSRY..DS.
  715- 1011 (351.73/223.15)	FAAQKRDIATANPSSEIPLVGFPRGRKPT.HTHQPEKLNGTQQSPSATRIPRSTSVSSSETSFDSSDDDYEREssparLATLKRKRPLSEAERSTTSSLERLSIAS.....ETDTHFTreDCSVFLgNFfsiTTDWslAGYFAFKQNHYSPvlirKEDHVqlaqlmvDQLAQS..SLSHKIDGCKPT.........PDLENDTVTLHTPL.DDTSVLGENERLDlKTLVSlhDNMQMTMETPSARPNMQRKDVKGSitkislphlhvhrgKDYLD.........ILPSSM...SFWETfGLEPANGPK....DIS.AYCIYPHFATEaaDAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.85|      39|    1082|     102|     140|       4
---------------------------------------------------------------------------
  102-  140 (64.72/33.84)	APERLIIGGTSLKVSASGSVTATDLIRSLSADPS......SNSSG
 1181- 1225 (63.13/32.84)	APKSLPFRVTSERVSPFQEGRCLHLAISRSVDQRwisaawSDSSG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05858 with Med13 domain of Kingdom Fungi
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