<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05857

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGLVMDDASASGSRQWEDSRNNHHQNGDLNASSAPQQNGGTGSFGKASQLANGPKEIGTSNALTTQEKERPGAVPDATQWKQPPELMHITQGFFPFAELVNRAVQQCWNDLSEMVTELAEIQVAPQPQQPSQIALANGKGSGNQTPDNIQKKIRILEFAQTKRTEFIKLLVLSQWSRQASDVSKLIDLQSFIRVRHMSYQAANQRVADMKMDLVRAQVANPDLKTALEILTTARASHMSDLGYIPPKPLSARRLLRTLQKINRTISTRLVTYDSIPSSFNNYRVHDGRVTFFVPKEFEVDLSIAEEDPLSQFYFIDIRFLFTPSSPIPKGRFFNELDSRINNILRAQGLIGCFDFLHNLVLVNKINILFKQAIDLSRGQWSGALRVELLHRILVIQYWPDKTWPEKTWPKSWIEIGVESGRQRGQQIPHIGFRWMREGQEVDSSDVFFDTETLSIEAVLRSVIAIHTSHLLRSAYNRLRSEALFASGQLSIKAQLSTVEPGSCHLHVQLTPSRHLEASLEPVSGSTSIHTKPSLLSRLEKGVASEDLASRISRLRCIAAMEEIESNTKMLGWESVDHRKFKVDIQGLFPRNILRASFFRNRLWSPLWIIAATTSLSGDDWWILHLNPRLTSGPGLLERNRQSTGGFSIQSTRILAGSSVLSKEPQNFFLDLDYSLTGILVMHSNALWLKESAFLSSLPSVEQLLLTPNLKIPCLYVNLDIGNFPEALRIGPSSGPRRKSYVQKSITLSYHGFDQQARQAIVVAYGRFQTPLRKFGLMMSKLDDCVLVRQKGKAFAIRFLVSPGQPIIVDLCERIQRLNIALSLLETLRLNKITVQSVSLSQLSFAYGQQEDLRAHISINVNRSGSLPDLDASILCSQSQSLFRLTFDISFDNPNPHNRIRQPLATIMNQSGPGVGIFSVLQNLKFTLPMLRSLDRLVAEPLRNPALKVHISVRSAKEYQIHYSGSQFRFLLTAAYRHERLVWTLKHIAKIQNRREMEEAVATKLKEKVFDGRGAGWQGIGNGAVAEVNEVGNLLSELDSCFSDVSITAPMEGPRDAQAEPQQKPIIGAAGSTVPEVGGGGGVLGMQGPHVSRVNLHSSSKTRGHDVITID
Length1111
PositionTail
OrganismTalaromyces islandicus (Penicillium islandicum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Islandici.
Aromaticity0.07
Grand average of hydropathy-0.243
Instability index49.96
Isoelectric point9.35
Molecular weight124082.38
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05857
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     296.45|      74|     119|     471|     547|       1
---------------------------------------------------------------------------
  471-  547 (119.11/86.57)	LLRSAY..NRLRSEALFASGQLSIKAQLSTVEPG...SCHLHVQLT..PSRHLEA.SLEPVSG....STSIHTKPSLLSRLEKGVaseD
  593-  664 (90.24/58.04)	ILRASFfrNRLWSPLWIIAATTS....LSGDDWW...ILHLNPRLTsgPG.LLER.NRQSTGGfsiqSTRILAGSSVLSK........E
  681-  746 (87.09/54.84)	VMHSNA..LWLKESA.FLSSLPSVEQLLLT..PNlkiPC.LYVNLD..IGNFPEAlRIGPSSG...........PRRKSYVQKSI....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     225.45|      79|      94|      36|     127|       2
---------------------------------------------------------------------------
   41-  127 (114.05/99.02)	GTGSfGKASQlANGPKEIgtsNALTTQEKERPGAVP..DATQW.KQPPELMHI..TQGFFPFAELVNRAVQQcwnDLSEMVTELAEIQVA.PQ
  139-  223 (111.41/61.69)	GKGS.GNQTP.DNIQKKI...RILEFAQTKRTEFIKllVLSQWsRQASDVSKLidLQSFIRVRHMSYQAANQ...RVADMKMDLVRAQVAnPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.62|      41|      91|     839|     886|       4
---------------------------------------------------------------------------
  839-  886 (60.08/54.15)	SLSQLSFAYGQQEDLRAHISInvnRSGSlpdlDASILCSQSQSLFRLT
  933-  973 (71.54/45.07)	SLDRLVAEPLRNPALKVHISV...RSAK....EYQIHYSGSQFRFLLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     176.47|      57|     476|     285|     351|       5
---------------------------------------------------------------------------
  285-  351 (85.44/76.40)	VHDGRvtFFVP.KEFEVDLSIAEEDPL.....SQFyfiDIRFLFTPSSPIpkgrfFNELDSRINNILRAQGLI
  763-  825 (91.02/55.18)	VAYGR..FQTPlRKFGLMMSKLDDCVLvrqkgKAF...AIRFLVSPGQPI.....IVDLCERIQRLNIALSLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05857 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGGGGVLGMQGPHVSRVNLHSSSKTRGHDVITID
2) MPGLVMDDASASGSRQWEDSRNNHHQNGDLNASSAPQQNGGTGSFGKASQLANGPKEIGTSNALTTQEKERPGAVPDATQWKQPPE
1078
1
1111
86










Molecular Recognition Features






MoRF SequenceStartStop




1) RQWED
15
19