<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05853

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMIPHPSAGVQNWAQHSRAPSAARPADLAAPRLDKPSMATAPLSLAQQSVIDLTANEAALPDTEHLNKKPRLDTTVSGLGGPGTATPTATKSADPRSATANGAIARPTPVSARGRPAYSFQDLVTETYGGNVFTGNPASGGSQTPKPPSPPPFPARPWKYGSVSHHQATNVAAPAQEGIFDRQVQTTPYHSEVPANAPALTADKVADYFPWSQYGNHPEDNLTDHAVKNGYYDKQPPSNCDVQAPTCKLSSQLKNRSSLQLLSSVFAAALEKRQAHNKIASTSTFKPPPRVTLTDNKREAWLRDLANPSVNLRRLSRTIPHGIRGKVLLDQCLSKGVPIGRAIWLAKCVGANEIRAFKRKGTSGPLSQGLEIKWVREWTASVQLFIEGVIQACGKEGWKQKITYAVRLAARLFFENLLDQDCFLDWYLSCLENSTLDATPVWLLMLGVYWESLARFRKRGRRMAEALLEKLRQAHAVEPRTTYQPLIDRLVLLVRRLCRECSSSLVLPRSWDQYRDLVSSSLDVEDVTEKAILEIITTRNARVKKQKDCRQSIQRSPHQQIIKLLDTALSTYDVPALSLACLDAMKDREALVHETLEWAASRFRHGLVRVYITVRLLRKWKRLGMDIDGYIFSFIMKARSNNSIHMVNVQHVIVELIRSQTFSVSRYLQWLVARGAVEQYCRNSSESSTIPVDIELLSHIPINRLPRHLRNLRDMLMNRAGLVVSEKELSPAIKSDLKQRLPEIFETDDSDDTMHRDVDYSRLTWAVKAEIGQWIRGAVSEHYGDDPRHGVKGYESGVESSSLTHEEFVVIRSTLEEYGDIAMLADVLIDASNSDDVRVLVSAVDTLNRHFSCFTVIGALNDLFRNFYGAFLRVKQYGEPLYDLAYSLVEVGHRLPNELNAIILLRQELSRGDRKLAVAACSPVSDHMAETLNDANPSFNDDMDQFLSSGNSMDESTLIIVFQKLIQQLINSHEGKEGFTTETTCRHLVQLRSFNPKQFDLLLIQWIGDTIKSSTRPKLSRFLGPLIGIGCVTLPGFTLLVKKLSHEESEIPALPDFQLDFLGLILPSAENRFSSQFLSYRFELAQEEFLSKHANEVFTAIQDTAATMTRAPANDDASLQQLWSKRTVPLLREILVRHSGDDAQNYIHVMLKENPAALGIARDALDQLLNFDSEPSRNENSLSEAESTINMADNFSLPFCQMKLQMLFNTEAGDDVRNSIVDVMFKSAVADVQAGQTHWLDLVTLMSQEAVEQVRQKAENSFFAVAQSDSSLDGASDVDRSAIHGNAKVYLSIVDGLADSIPEGGVPSIGPVLVEKMNTLLQKLIMIQMTCRNLREDPSSVEHEQIARTLSICEESFLFWFTAMLRMVKIHRAAFDQPWSPTLQRPNALLDQSRLLVSICCLALSPLNLTSRPPVGMSSVSISAVEQKARVGNTIQTYALDIASSLIDTLPDEARVQCARFLKERCPPFLHVQNEPRLLYLFGPVSDVILSSNQSVSGSSPAPSGAISSALTPSANPPAANTGVVAAPAGISEDPNSMANRLRVQSRGRVVGPYYLRSWELLEEAAPVVGANDTAVDLNFFGARKAKRRCDLRHPACRRCVVKGIECHYVSTRLHDNGTNSSNSGVNPKRQKPKKSREANVLVRQGQRQGLGHGHSSADDILLSLMSDSSPEEEKKNTFPILSAMSNNNAFSYPFYNSYECQFFLTPTSWHVTNPGHRSTPRPGWKMSHLHDSVQQVLRWVKQWVEDGSNAFIHRYLYSGKMPKCIQDAYTASAAYFGCNERNRELVLGIIEDRVRMLLEEQEEGSEWSWKTGGATATAAAGKGVVAEHLARVQALLVYQVLRLLDGDTRQRSLAEGLIPTLQGWSMQMLECALLSSQYVQQLAITDRDMTINPAPAAQKRQSEWQAWILAESVRRTWLVAGHTQCIYGLLRNGISLCPGGLMFTTRAGLWQADSADEWWEMCWQKDVLFCHSLETHTQLVKKARPHEVDDFGRFVMRIISEKEEVERMWLQSV
Length2013
PositionKinase
OrganismTalaromyces islandicus (Penicillium islandicum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Islandici.
Aromaticity0.07
Grand average of hydropathy-0.286
Instability index47.16
Isoelectric point7.08
Molecular weight224577.94
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
DNA binding	GO:0003677	IEA:UniProtKB-KW
DNA-binding transcription factor activity, RNA polymerase II-specific	GO:0000981	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro
zinc ion binding	GO:0008270	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05853
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     173.00|      64|     216|     847|     957|       1
---------------------------------------------------------------------------
  778-  845 (91.27/78.13)	V..SEHYGdDPRHGVkGYeSGVE.SSSLTHE..EFVVIRSTLEEyGD....IA.......MLADVLIDASNS..DDVRVLVSAVDT
  870-  951 (81.73/84.13)	FlrVKQYG.EPLYDL.AY.SLVEvGHRLPNElnAIILLRQELSR.GDrklaVAacspvsdHMAETLNDANPSfnDDMDQFLSSGNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     190.24|      56|     101|      87|     144|       2
---------------------------------------------------------------------------
   87-  144 (93.00/60.28)	TATKSADPRSATANGA..IARPTPVSARG.RPAYSFQDLVTEtyGGNVFTGNPASGGSQTP
  186-  244 (97.24/57.06)	TPYHSEVPANAPALTAdkVADYFPWSQYGnHPEDNLTDHAVK..NGYYDKQPPSNCDVQAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.40|      31|     217|    1424|    1454|       3
---------------------------------------------------------------------------
  676-  709 (46.68/37.48)	VEQYCRNSSESSTIPVDIEllSHIpINRLPRHLR
 1424- 1454 (51.72/42.57)	VEQKARVGNTIQTYALDIA..SSL.IDTLPDEAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     232.80|      73|      97|    1715|    1793|      11
---------------------------------------------------------------------------
 1715- 1793 (120.37/97.04)	GHRSTPRPGWKMSHLH.DSVQQVLRWVKQWVEDGSNAfiHRYLYSGKMPkCIQDaytASAAYFGCNERNRELVLGI.IEDR
 1813- 1887 (112.44/72.80)	GATATAAAGKGVVAEHlARVQALLVYQVLRLLDGDTR..QRSLAEGLIP.TLQG...WSMQMLECALLSSQYVQQLaITDR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05853 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DNGTNSSNSGVNPKRQKPKKSREANVLVRQGQRQG
2) GGNVFTGNPASGGSQTPKPPSPPPFPARPWKYGSVSHHQATNVAAPAQEGIFDRQVQTTPYHSEVPANA
3) MIPHPSAGVQNWAQHSRAPSAARPADLAAPRLDKPSMATAPLSLAQQSVIDLTANEAALPDTEHLNKKPRLDTTVSGLGGPGTATPTATKSADPRSATANGAIARPTPVSARGRPAYSFQ
4) PWSQYGNHPEDNLTDHAVKNGYYDKQPPSN
1615
128
1
209
1649
196
120
238










Molecular Recognition Features






MoRF SequenceStartStop




NANANA