<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05851
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MADDKFTLPLRPLIEKRDRPDPLPLEIAQINAQWGSFRDVSEESLRAKIEEEKSKEYTTEEEEGEGAGAELDTTERLDQLYKRRAEIIQFAMQAHMEAMFALDFISLLLSKHTPRQAETSMSAYLKQVAPLGSLNSEIISPPPKSEAVVKDTKSVSRGWRLQSFNAAADKLLKSASRLENEVASETRYWHEVLAVKDKGWKLCRLPRQGQTLGVQYGFLEATPIFRDRGLAALRRSEDGALILDKGLVPAKAKTVRVRVKGHGTITGCSRPYRSAAQDPDSIEGRILQARDTLYEEELFHELFREARIMGSQGVTTRQNLVQFPVSEEQDILLDLVDPDQEAYVDGEETKSEEHNVLADALAHSIRILLCYAHRQNLRRRTQPPPPLSPKRRHIPEYHLLRPVMAYLQHSFHVRWLETFMKDVYGVLQSAGLSCSFTATPYSSVNLFNIDRSVPKVEGLIRQFLLPLESTFSADLLTPQSSFKVKTRTNLSVPPFGTHFEISLNLPHYPDVHPPHRIGLQDQAATIITHFIMLDIVAAIESQTSPASSISKTEAKSVSWEPTYPHHGELLAVSTDGKQKKMKVILSRDELVVQTYDVQGVERYSRATPETTPGLQTHTWKAGPTTAPSLMEYVAAVSQR |
Length | 639 |
Position | Head |
Organism | Aspergillus lentulus |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.433 |
Instability index | 56.33 |
Isoelectric point | 6.40 |
Molecular weight | 71975.94 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP05851
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 74.66| 23| 44| 134| 173| 1
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134- 161 (36.30/48.88) LNSEIISPPPKSEAV..VKDtksvsRGWRL
178- 202 (38.36/16.17) LENEVASETRYWHEVlaVKD.....KGWKL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 113.38| 33| 94| 507| 539| 2
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507- 539 (59.94/40.30) HYPDVHPPHRIGLQDQA..ATIITHFIMLDIVAAI
602- 636 (53.44/35.11) RYSRATPETTPGLQTHTwkAGPTTAPSLMEYVAAV
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 57.71| 20| 37| 432| 454| 3
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432- 454 (34.88/26.67) LSCSFTA...TPYSSvnlFNI.DR...SVP
467- 493 (22.83/10.50) LESTFSAdllTPQSS...FKVkTRtnlSVP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 85.66| 27| 93| 205| 244| 5
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205- 231 (47.72/44.78) LPRQGQTLGVQY.GFLEATPIFRD.RGLA
248- 276 (37.94/14.34) VPAKAKTVRVRVkGHGTITGCSRPyRSAA
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 95.89| 30| 33| 304| 333| 8
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304- 333 (48.74/36.46) REARIMGSQGVTTRQNLVQFPVSEEQDILL
340- 369 (47.14/35.02) QEAYVDGEETKSEEHNVLADALAHSIRILL
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