<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05851

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMADDKFTLPLRPLIEKRDRPDPLPLEIAQINAQWGSFRDVSEESLRAKIEEEKSKEYTTEEEEGEGAGAELDTTERLDQLYKRRAEIIQFAMQAHMEAMFALDFISLLLSKHTPRQAETSMSAYLKQVAPLGSLNSEIISPPPKSEAVVKDTKSVSRGWRLQSFNAAADKLLKSASRLENEVASETRYWHEVLAVKDKGWKLCRLPRQGQTLGVQYGFLEATPIFRDRGLAALRRSEDGALILDKGLVPAKAKTVRVRVKGHGTITGCSRPYRSAAQDPDSIEGRILQARDTLYEEELFHELFREARIMGSQGVTTRQNLVQFPVSEEQDILLDLVDPDQEAYVDGEETKSEEHNVLADALAHSIRILLCYAHRQNLRRRTQPPPPLSPKRRHIPEYHLLRPVMAYLQHSFHVRWLETFMKDVYGVLQSAGLSCSFTATPYSSVNLFNIDRSVPKVEGLIRQFLLPLESTFSADLLTPQSSFKVKTRTNLSVPPFGTHFEISLNLPHYPDVHPPHRIGLQDQAATIITHFIMLDIVAAIESQTSPASSISKTEAKSVSWEPTYPHHGELLAVSTDGKQKKMKVILSRDELVVQTYDVQGVERYSRATPETTPGLQTHTWKAGPTTAPSLMEYVAAVSQR
Length639
PositionHead
OrganismAspergillus lentulus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.433
Instability index56.33
Isoelectric point6.40
Molecular weight71975.94
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05851
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.66|      23|      44|     134|     173|       1
---------------------------------------------------------------------------
  134-  161 (36.30/48.88)	LNSEIISPPPKSEAV..VKDtksvsRGWRL
  178-  202 (38.36/16.17)	LENEVASETRYWHEVlaVKD.....KGWKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.38|      33|      94|     507|     539|       2
---------------------------------------------------------------------------
  507-  539 (59.94/40.30)	HYPDVHPPHRIGLQDQA..ATIITHFIMLDIVAAI
  602-  636 (53.44/35.11)	RYSRATPETTPGLQTHTwkAGPTTAPSLMEYVAAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.71|      20|      37|     432|     454|       3
---------------------------------------------------------------------------
  432-  454 (34.88/26.67)	LSCSFTA...TPYSSvnlFNI.DR...SVP
  467-  493 (22.83/10.50)	LESTFSAdllTPQSS...FKVkTRtnlSVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.66|      27|      93|     205|     244|       5
---------------------------------------------------------------------------
  205-  231 (47.72/44.78)	LPRQGQTLGVQY.GFLEATPIFRD.RGLA
  248-  276 (37.94/14.34)	VPAKAKTVRVRVkGHGTITGCSRPyRSAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.89|      30|      33|     304|     333|       8
---------------------------------------------------------------------------
  304-  333 (48.74/36.46)	REARIMGSQGVTTRQNLVQFPVSEEQDILL
  340-  369 (47.14/35.02)	QEAYVDGEETKSEEHNVLADALAHSIRILL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05851 with Med17 domain of Kingdom Fungi
Unable to open file!