<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05845

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGSITNIRVIDGFSNIYWRIYTEEPNIATLSGDSPTNGFTILRHLSRLKDLELRLRNLDCLVSSYPRRLGLWVFSATPDFESLGPLCSNGTSDDPSKLFLGSATLKVSASGSVTSKELVKNLSAEPVNAATNSQGVQRRQNGPNPPRRTDGHGSSAAIYASFISAVTGALSLQLIRCNNAIPLGSRTLFTVVAEDYYDNPRIDNDNPAAVPSLTSLQIQLTSVGKLTVSLQTISQPGILRLCGPYDTFVGVHNAHPGCDLWLSPSGSIARLVATHSDSQNASSGHTVANPPNSSNLEEWKALVIEWLGNYGLPLISSEEEPWVEVEVWEPFYSRLAGETWRQNEEGASVLPLKRILWPARYCFTRKKPTSLDPFLGINDTFPVIDEPLGFAEKWFGMGQVDHEETDSKPASRPEPETKDQETPLSRPDLPEGIESLSRAAEYPDLQASNLVYPTPPDGAFPVGPNAPSASDAAAEDLDSRHLTNRALAKVKTKEGASTRERSDHDVLMSFGPSPGLIVGSGLYDTNDDDDLFGEINQRDFGSKGITDADFSFFDDPEFNHLSGEVNEMDVGAQETPEIAVDAEDPKPQPLPLEQPLTDNLPGQRDTTEQVDTILVHPEEKISNPQPADVPLSASMQISSPVNEDNQTISPPLSPIEVKKTLFAGPNEDSKLSVRKGHLQGHYNPVAFKENILDWDQKYGAEGKFRVTGALVNHHTVPASTTGDIPTIGLPRRNARTKNPHGPARNINKPKSPASDLDQPMPSESDSDSTSDPSDDSDGNLSNSDESVATFVTRKRKRARSYSGSSVNLPQEKPSARSEQSIATSRADDLVFLGNFLSTFSDWSMTGYFSATQKQLAPVLIRKDAQIQVAQLLVDQVTQSCLDHKVDGILGVSEFESKAYSLRTFLEDTAFMGEIERLDLNGFVSLQENSGLSPPPTATMSRQSSQRKENGKSSMSKLAPPHLRIRRGKDYLEVLPPAISFWETFGLEPAYGSKDISAYCIHPQIAAEAANDFLERLGLLYSSCNLGQHTRASRSTGFDRGMCSWNIGAPGEFNYHYIMQSLKSICDKLVTALLKSPPTKDTVVVYIINPFSHAAALVDICSAFWGLFRKYIDEAEKQQAGQANELVLQIVPFHFIMSTESLVVPPQTQYLSLALEVYSRCPPKSLQSCLLNCAPPMLIAEPVPKTINFKLAPDRSSPLQEAKSLHIACSRSYDQRWISVSWTDNTGTLQRTMSYCLRFQNSNAARSILEVRNEIWTATKIIMEKTQARWKIIIVNTEPVDQDEVDTWTSLVEQYNMTKPFLSDLTILYANTTPDLYLEPPPQPLSMSVFNPQISSTPVATPNPSGNAFSPEQSGNAPTPPSGGNAPTPTEIPPDAESECLLTDICDESWGIILSHCLNSSPHLTDYRPALASGYLLRRKGPTDSDGAFAMNVNLIYSQKPPSSYDNLLRDIIARYRDLATLARATGTRTVQQNTFPWHIATAVRAQELLSYIL
Length1497
PositionKinase
OrganismAspergillus lentulus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.08
Grand average of hydropathy-0.403
Instability index53.60
Isoelectric point5.07
Molecular weight164334.18
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05845
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     415.61|     202|     277|     457|     733|       1
---------------------------------------------------------------------------
  457-  575 (112.13/55.77)	...............................................................................................................................................................................PTPPDGafpvgpnaPSAS....DAAAEDLDsRHLTNRAlakvktkEGASTRERSDhDVLMSFGPSPGLIVGSGLYDTNDDDDLFG.EIN..QRDFGSKGITDADFSFFDDPEF..NHLSGEVNEMDVG
  576-  683 (112.19/180.43)	AQETPEIAvdaedPKPQPLPLEQPLTDNLPgQRDTTEQVDTIL.VHP.EEKISNPQP..ADVPLSAS...MQISSPVN.EDNQTISPPlsPIEVKKTLFAGPNEDSKLSVRK...GHLQ........................................................................................................................................................................................
  740-  850 (105.89/19.29)	.......................................................................................................................ghynpvafkenildwdqkygaegkfrvtgalvnhhtvpasttgdiptiglprrnarTKNPHG........PARNinkpKSPASDLD.QPMPSES.......DSDSTSDPSD.DSDGNLSNSDESVATFVTRKRKRARSYSGsSVNlpQEKPSARSEQSIATSRADDLVFlgNFLSTFSDWSMTG
  857-  967 (85.39/ 0.00)	KQLAPVLI.....RKDAQIQVAQLLVDQVT.QSCLDHKVDGILgVSEfESKAYSLRTflEDTAFMGEierLDLNGFVSlQENSGLSPP..PTATMSRQSSQRKENGKSSMSKlapPHLR........................................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.91|      11|      15|    1344|    1354|       2
---------------------------------------------------------------------------
 1344- 1354 (23.64/10.45)	TPNPSGNAFSP
 1362- 1372 (22.27/ 9.39)	TPPSGGNAPTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.10|      14|      15|    1185|    1199|       3
---------------------------------------------------------------------------
 1185- 1198 (24.57/ 9.41)	PVPKTINFKLAPDR
 1201- 1214 (22.53/ 9.32)	PLQEAKSLHIACSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     352.60|     111|     899|     321|     439|       4
---------------------------------------------------------------------------
  321-  439 (182.21/126.07)	SEEEPWVEVEvWE...PFYSRLAGETWR.QNEEGA.SVLPLKRILWPARYCFTRKKPTSLDpfLGINDTFPV....IDEPLGFAEKW.....FgMGQVDHEETDSKPASRPEPETKdqetPLSRPDLPEGIES
 1215- 1339 (170.39/97.15)	SYDQRWISVS.WTdntGTLQRTMSYCLRfQNSNAArSILEVRNEIWTATKIIMEKTQARWK..IIIVNTEPVdqdeVDTWTSLVEQYnmtkpF.LSDLTILYANTTPDLYLEPPPQ....PLSMSVFNPQISS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.88|      20|     283|    1091|    1110|       7
---------------------------------------------------------------------------
 1091- 1110 (38.44/23.76)	INPFSHAAALV.DICSAFWGL
 1375- 1395 (35.44/21.31)	IPPDAESECLLtDICDESWGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.81|      17|      18|    1413|    1429|      11
---------------------------------------------------------------------------
 1413- 1429 (27.97/17.40)	ALASGYLLRRKGPTDSD
 1433- 1449 (29.84/19.15)	AMNVNLIYSQKPPSSYD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05845 with Med13 domain of Kingdom Fungi
Unable to open file!