<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05843

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDSAQQFDHATIIDLPGSSQGAAHGTFDIFEWYPHYQSCQRYFLDHAQHSVTVQALCAFLNIRLPFQRIPHPVSSSSSKASTPSAGLPSSVSESSPHPAPSVSLIPYIRRLVATGMDSPGVLQGFFGDDWTAGVGYLHEQERRNYLFAAKSGGWAAVKRDYDMPPLETIPFLRPLQGTVDSEIEAAERSWKGKDGSKCYTLMTDIRVIQDAMLSVSTGSTPKTNAEAIAIFFSIIDWIHAVVSWHNSHFDPGQHSSGMMSSPDVVSLFESLGILLAALSGTGKGLEVLSAESHEGLKVKLGQALSAYLPLCVEVSLPLRNRLDGLQKEFNLYGERAPKSLDVPMMENMNVNALQFEASVMDGPVINSRAGLYVFINAMLVGRPLVDDGMLINYLANRYGGHYEALIEEILTAAFDVLSNGMYRNESSRTMFVFRSFLVNKLPAFFAAMLASTMVSIPMEMCISHALSRLDPNTFPSFSQMFEMQGNTVLSDVRQEFLFACASHKLIPESSIERLLGENPMQTLPVGYNKDELVSQINANPERAEQLINEIESMEGNAGAIIGAITEVMHNLCSQKESMTLKNICNSLSRRPQALDVVLIFRNPKQVLQPLCALLDSWHWDEDQGENQPVYDEFGSILLLVLAFKYRFDLRPADLGISSNDSFVLRLLERGSCSQKLDALDEKQNKNLGSWIAALFIAEGISEETMSACSPQEFYLLVATLFSQSLEACETGKLEFDTLKGGFEYLLEPFLLPSLIFALTWLGNHIWETELDPSIPLKALHSLVNPSSISGEAREIHRTVLNITARTLEEQLKDVRTRHPSRTDIKPILDSLEPCLSFQRVGSSHRSELESWTTHSGGGLLGSIRSTFQSLVLWSTNPEVSMAPPPYTHRQLIAGVRMLGASRVFPALIEELKLQTEAGNGPLALDLAATLICAPMAETFSVEQNSHQPVDPNKEALPRCGILTLRDVLALQHENVPKISEKDPLRAEVIVRLYRRVNALLAPPSQVPNLDVNNIIQNMQLGGVGVGVGAGQMELDAAGAADDGVGPDDAENIHRMIDNAAAAAGLDSSGTGLDTSIDDVLNAADMAVGNPEFLDLDMEGMF
Length1101
PositionTail
OrganismAspergillus lentulus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.059
Instability index49.29
Isoelectric point4.93
Molecular weight120712.04
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05843
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     208.45|      60|     101|      10|      72|       1
---------------------------------------------------------------------------
   10-   72 (100.35/79.59)	ATIIDLPGSSQGAAHGTFDIFEWYPHYQScQRYFLdHAQHSVTVQALCAFLNIRlPFQRIP..HP
  113-  174 (108.10/70.74)	ATGMDSPGVLQGFFGDDWTAGVGYLHEQE.RRNYL.FAAKSGGWAAVKRDYDMP.PLETIPflRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.27|      14|      25|     359|     372|       3
---------------------------------------------------------------------------
  359-  372 (26.59/17.80)	VMDGPVINSRAGLY
  385-  398 (26.68/17.88)	VDDGMLINYLANRY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.23|      22|      26|     256|     279|       4
---------------------------------------------------------------------------
  256-  277 (37.03/19.08)	SGMMSSPDVVSL..FESLGILLA.A
  279-  303 (27.19/17.54)	SGTGKGLEVLSAesHEGLKVKLGqA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.21|      16|      21|     733|     748|       5
---------------------------------------------------------------------------
  733-  748 (29.44/20.78)	LEFD.TLKGG..FEYLLEP
  754-  772 (22.78/14.18)	LIFAlTWLGNhiWETELDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.28|      25|      26|     946|     970|       7
---------------------------------------------------------------------------
  946-  970 (44.58/28.58)	HQPVDPNKEALP.RCGILT..LRDVLAL
  972-  999 (33.70/19.92)	HENVPKISEKDPlRAEVIVrlYRRVNAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.26|      23|      26|     528|     553|       8
---------------------------------------------------------------------------
  528-  553 (31.85/28.03)	NKDELVSQINanpERAEQLINEIESM
  556-  578 (39.41/25.02)	NAGAIIGAIT...EVMHNLCSQKESM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     100.41|      24|      26|     440|     463|       9
---------------------------------------------------------------------------
  410-  435 (26.01/12.32)	.L.TAAF.DVLSNGMYrnesSRTMFVFRS
  440-  463 (41.65/23.98)	KL.PAFFAAMLASTMV....SIPMEMCIS
  468-  490 (32.75/17.34)	RLdPNTFPSF..SQMF....EMQGNTVLS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05843 with Med5 domain of Kingdom Fungi
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