<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05841

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMIPYSSAGVQSWGQPLHAVYSGTGRADLSQPLGQPDRQSEQASMPVPQLQGRPPALIDLTANDGDVLEREPPAKRLKIDVHAGSVAGDGSPASAGVGESKSTPSTTTSKPPSLSWRARPVWSFQALLSEVSGSAEINGESAAGVVQDVKPPSPPSFPGPPWKFAPADTKASDPAGAQDGAPAKEVQTTPYHIETPSVAPVMGGEKVADFSPWMGNHPEDVLNEQTAKQGYYDRTQVSQNESNTARPSLYAQLKHRSGLQILSSVFAAALEKRQGHNMVTAPSTFKPPPRVTLTDNKREAWLRDLANPNVPLRKLSRTIPHGIRGRVLLDQCLTKWVPVGRAVWLAKCVGANEIRAFKRKGTSGALAIGLEAKWVRDWTANVQQFLEGVITSCGEADWKMKMTYAVSLTARLFFEQLLDHDQYLGWFLTSLEAAPFNTLPVWLLMLGIYWSNILRYRKRGRRLAELLLDKLQLAIKSDSATSLRPLTDRLSLHIRKLTLEHTSSMVLPQSWEKYKDLLSSCLNLNDNVHRAVFQNLAERNARVQRPRKCEETTQQPPQQRIIQLFDSIGSSHDITSVSTASLGAIDDKAALVLKLLEWAATPFRYGVSRVYTGARLLRKWKIAGVDVDTYIISFLGESQMRDQLNMDNIYHIVSELVRSQTFSVGKYLQWLMAKGVADFPRNSDHRPLSGDLALLMQLPVSRLPEHVHNLRNTLLHRAGVEVPKEASTIAILKASIAERLPRIFGSAAASAVSRGPLPSDLTWAVKSELGQWIRRGVTEFGRDPRDAFRELHLDPGAEHFALTPGEFYTVRDILESFGDLSILADVLKQVTVCNDGIVLASAADTVNYHFRSFCVIGATTDLFKRLVESYARLKRLGSTSLDLIFSLIDLGLRLPGELNTVALLRQDLSRIESKSSMAAPSPLSDHIPSSFNEADPLFLLKLDQLLSSASGIDESTLDMIFNLLVKQIESSGGHAKLSVNETCRYLSYLRPFHPKRFDIMIVRWICGLLRSTTGGILSQVLPPLIGVGCVTIQAFVFLVRRLLKSENMISNPTDLRIGLLQLLVPPPAGQSRYFDMVTYRFHLSRKEFLFKHPEEVFDIIRDAIALIDSQSQERDFCQGQVDLGHSAMVLLQILLTKDPESAVQHCTEKLIGQHPSAVTVLTRALDFLLGLDTKAAPPDISVAEKVIELTNDFSLPFCQLKLQLLFNAGTKGDVRNEIVDVMFKAAVADSRSRRSNWVGLVRLMSHDAIQQIRERAEKNFFAIPLFEESPDGCSSFAADNSSSLETAKMYLTIIEKLAYSIPDVGPQAVVPVLTEKMDLLLQRLISMQANYSGTTELSHGVDAELMIRSRAQFERALAFWFSALLRMIVLHRTAFSVPSAALRPSALPEQTRLLISIFCITLARLPDSVLRLFPAADYFPHSMRAGDCRPCPGILLQTHALDVAASLIDTFPDEARHQCARYLREKCPPFARVQNDSRFLYLLGPLGDSPSSNLTLPVSIPSPAASGSTPAPTPSGNPPGGFSHPQQPAFVSGVPTGLPDGLNCAASHLCLQYRGRAIGAYPVRPWELLEDAAPVAGTNDTAVSLGYFDARRVRV
Length1594
PositionKinase
OrganismAspergillus lentulus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.117
Instability index46.16
Isoelectric point8.45
Molecular weight175637.37
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05841
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     481.94|     125|     325|    1033|    1169|       1
---------------------------------------------------------------------------
 1033- 1169 (180.50/153.20)	AFVF..LVRRLLKSENMISNP.T.DLRIGLLqllvppPaGQSRYFdMVTYRFHLSRKEflfKHPEEVFDIIRDAiALIDS.......QSQERDFCQGQVDLGHSAMVLLQILLTKD....P..ESAVQHCTEKLIGQHPSAVT..........................VL..TRALDFLLG
 1177- 1320 (134.80/86.57)	PDIS..VAEKVIELTNDFSLPfC.QLKLQLL....................FNAGTKG...DVRNEIVDVMFKA.AVADS.......RSRRSNWVGLVRLMSHDAIQQIRERAEKNffaiPlfEESPDGCS.SFAADNSSSLEtakmyltiieklaysipdvgpqavvpVL..TEKMDLLL.
 1357- 1483 (166.64/109.09)	AFWFsaLLRMIVLHRTAFSVP.SaALRPSAL......P.EQTRLL.ISIFCITLAR......LPDSVLRLFPAA......dyfphsmRAGDCRPCPG.ILLQTHALDVAASLIDTF....P..DEARHQCARYLREKCPPFAR..........................VQndSRFL.YLLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.48|      13|      15|       4|      16|       3
---------------------------------------------------------------------------
    4-   16 (26.07/14.74)	YSSAGVQSWGQPL
   20-   32 (24.41/13.32)	YSGTGRADLSQPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.54|      16|      16|     250|     265|       4
---------------------------------------------------------------------------
  247-  262 (26.29/15.96)	SLY.AQLKHRSGLQILS
  263-  279 (23.26/13.27)	SVFaAALEKRQGHNMVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.65|      20|      21|     652|     671|       5
---------------------------------------------------------------------------
  652-  671 (34.93/17.96)	VSELVR.SQTFSVGKYLQWLM
  675-  695 (30.72/14.96)	VADFPRnSDHRPLSGDLALLM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.77|      15|      96|     342|     360|       8
---------------------------------------------------------------------------
  342-  356 (26.75/27.72)	VWLAKCVGANEIRAF
  363-  377 (27.02/14.09)	GALAIGLEAKWVRDW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     168.06|      41|      89|      71|     111|       9
---------------------------------------------------------------------------
   71-  111 (75.40/35.27)	PPAKRLKIDVHAGSVAG..DGSPASAGVGESKSTPS..TTTSKPP
  131-  154 (33.15/12.00)	...........SGSAEI..NGESA.AGVVQDVKPPS.......PP
  159-  199 (59.51/26.52)	PPWKFAPADTKASDPAGaqDGAPAK....EVQTTPYhiETPSVAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.56|      13|      18|     775|     787|      13
---------------------------------------------------------------------------
  775-  787 (23.58/15.05)	GVTEFGRDPRDAF
  795-  807 (23.98/15.44)	GAEHFALTPGEFY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05841 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GEKVADFSPWMGNHPEDVLNEQTAKQGYYDRTQVSQNESNTARPSLY
2) GQPLHAVYSGTGRADLSQPLGQPDRQSEQASMPVPQLQGRPPALIDLTANDGDVLEREPPAKRLKIDVHAGSVAGDGSPASAGVGESKSTPSTTTSKPPSLSW
3) PVSIPSPAASGSTPAPTPSGNPPGGFSHPQQPAF
4) SGSAEINGESAAGVVQDVKPPSPPSFPGPPWKFAPADTKASDPAGAQDGAPAKEVQTTPYHIETPSVAPVM
203
13
1496
131
249
115
1529
201










Molecular Recognition Features






MoRF SequenceStartStop




NANANA