<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05840

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVIMDNATVGRPGHVPDTQTPSNGDNLRNGSLHINGAAKGAKDHDPDRESYTGKPGIDGHRALPELPHITQGFFPFSTLVNRSVQQCWNELSDLITELAAIQVSPHSSTPLLPVNGKSPGNQSPENVQKKLRILDFAHAKRAEFIKLLVLSQWSRRARDVSKLIDLQNFIRARHQAFVDALQRVGDMKRDLVQAQVANPDLQTALEILSKGSLESLADLGYKSSKLLTARGALRRLHKINRIISARLALHDSIPHPFRTYRVHDGRVTFVVRGEFELDLSVGAESELSQFFFVDIRFLYFPSSDIPKGRMSNEIDAKVNDKLRESGLTGCFNFLHGLVLTNKIHILFKQAIELAKGLWSETLRVELLHRTLVIQYWALKPGPKSWVEVGVKSGNGEADCLGFGIPCLGLRWMRDGQEVDSRDIEFDPEDLSMECLLRSVIALHISYLLSSAYGILSEYSLFSAGTLSSQAILNGTEPGECQLSVQLTGSRHLRVSIEPMSGAVILSATPGLSERSESDASLDRSTIDDLVARVSQLRCIAAIEELESNVRILGFETVSPKGLRNDIRKVFPANVLRFSLFWHPSWERNWVVAATSSITGDNWWVVQLRRSSEVATDFSVSDTSVPLCSGHSMSDTFLATSHQARPSSFPDLGYCLSGMVAIHANVSYLSDLQSVEFHPPLCALKVESDLQIPDIFIRYQVSNLPRALQLVLPAGLKRKNLLKDTVRLAFHGIDRHKNMAIFVAYGNLVGPWTDLCTLVSKSDSSLVFKRGGSGFALRLLAPAGRPVIVQLFKSLQTLECTLSILDFLRQRKLTPQSLSLTHIAFAYGPRRDLSAIVGIELSEVPSSAELDPVRILAGTDPLLFLTLGIRFKHPNPHRRVQGSLAALLNHASNDSGLDFVTEILSFTLPLMRALEQITSNASRQESFRLQVIVRNAYTFLLHYTYQGFRFQLTTSQHSGQLTWVLRELSSPGPGPGHDQLKARLRGTLYHSKGNGWKGLGNGVVASAEGVGNLIWALDGCFTGAQHNTWLPRETKSDHDYSTQPVPEKQSQTGAPSQAGMAKDTTTTANFVNDRSLQRNPVASNAADVITID
Length1093
PositionTail
OrganismAspergillus lentulus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.147
Instability index44.07
Isoelectric point8.52
Molecular weight120634.11
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05840
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.17|      36|      71|     676|     716|       1
---------------------------------------------------------------------------
  676-  716 (51.45/63.53)	VEFH.....................PPLCALKVESDLQIpdIFIRYQvSNLprALQLVLPAG
  729-  785 (51.72/40.11)	LAFHgidrhknmaifvaygnlvgpwTDLCTLVSKSDSSL..VFKRGG.SGF..ALRLLAPAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     214.61|      70|      77|     157|     233|       2
---------------------------------------------------------------------------
  157-  233 (102.69/98.09)	RRARDVSKLID....LQNFIRARHQAFvdalqRVGDMKRDLVQAQVANPDLQTALEI.LSKGSLESLADLGYKSSKLltARG
  236-  310 (111.91/86.81)	RRLHKINRIISarlaLHDSIPHPFRTY.....RVHDGRVTFVVRGEFELDLSVGAESeLSQFFFVDIRFLYFPSSDI..PKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.87|      39|      49|     824|     870|       3
---------------------------------------------------------------------------
  826-  864 (65.65/48.75)	FAY.GPRRDLSAIVGIELSEVPSSAELDPV.RILAGTDPLL
  872-  912 (59.22/26.39)	FKHpNPHRRVQGSLAALLNHASNDSGLDFVtEILSFTLPLM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.29|      46|      49|     918|     966|       5
---------------------------------------------------------------------------
  918-  966 (73.57/48.66)	ITSNASRQESFRLQVIVRNAytfLLH...YTYQGFRFQLTTSQHS.GQLTWVL
  969- 1018 (72.72/40.41)	LSSPGPGPGHDQLKARLRGT...LYHskgNGWKGLGNGVVASAEGvGNLIWAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     167.15|      53|      71|     484|     539|       8
---------------------------------------------------------------------------
  484-  539 (77.14/60.37)	LSVQLTGSRHLRVSIEPMSGAVILSAT....PGLsERSESDASLDRSTIDDLvaRVSQLR
  554-  610 (90.01/59.63)	LGFETVSPKGLRNDIRKVFPANVLRFSlfwhPSW.ERNWVVAATSSITGDNW..WVVQLR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05840 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MPGVIMDNATVGRPGHVPDTQTPSNGDNLRNGSLHINGAAKGAKDHDPDRESYTGKPGIDGHRA
2) PRETKSDHDYSTQPVPEKQSQTGAPSQAGMAKDTTTTANFVNDRSLQRN
1
1032
64
1080










Molecular Recognition Features






MoRF SequenceStartStop




NANANA