<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05830

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMRGAGLLVASEHDGGDILLWVFRTRGKLSDESGEPQSGLDSEGQLSPSTLAEPLDHVSQTETTKPRQMFYVALSAFVQRGLDLTSRVSAIDFLTWIVMPQFGPVPSDWTPRTDSNLIVSLTLQTTANGALACLTEVNPTHLSLASHYLLRRPLSNGMIDLPLILVPLGLSAICVRQVASGDQENWLPEAASWFYKQYPFLSLKELAQSTNWMIVKQQSRLLRDAPESDTESFDSTNSLLWPACLCMLRRSGVIDIGDIPDGFLQAGAEASNYEDPFRKAEEWYLAKAERETAFESAKLGAVPLYDPSSQILEDDLESATSPLYLRHIDSGNSNAVYPTPPDGIAPGPSHVAPQTTQIADETMLDDEPSRSERHGEDDVATVQPPDRDNADDDGDLFGDIEGDTFGNPDITDADFNFFDETVAAKLAMSSRMNSEKRVSVRDQNQVAHAPNCDVKMADMPTFDPDARNSSSDLNGSKDVRSGTAAILQIQTENFLGEGGERAHAPQTLSPQCGVATPPLSPLIVKDRLFSLGYFPTSQDSNNGDHHFTPVTFRDEANVADSKYSNGGKFGTLTNGTSAGYTLSSSKRSISLRDFLGQQKANEQASSASVIGRLIRHRLLNNDSDDSDTESTITNHSGLMRKVRPRIMYDTDAQDIEMEDGKVNKVVERRQDLRPKLNQSQMIRKEWAKVSDSASTSTDTWDPYNIAVITQLLAEQPEESRTSLWDMFDFDGPDIIEVAQILAANAAISYDKSSEFYTDTFDGWNSLKIERDRSTASITKLSQTKALSLSSLAATSMAPTVVTATEASSQNIPRPTPKRSATVHGSSAFGQQLFPLHSPYVRLRRTDATWEMLPSAVAFWEVLGLEPIHGPKDIVADLVMVGSEDFRDSCLVFFRDMQYCYETCKLGQHDLGFKIHRKAPASNSGSPNDTPARMLLSAFKNALLDLSKKMNQRSRQHSSRPSVIYLFVPFRDASMSKYVCACYWLFLKELVPEAKNVVLHMVSLEQVICQDDTTTIKSQLLIQSARTLYDKVDLRRADGTQDFWKISNSPSIALVSPIPRKINFSMSETPPLSLLQEASVLHLAYGISADGRWLNAAWTDYTGNHQKRCAFCLYKADYRSVLSRVKDYTKTLLSPSTTWRLIVAFTGNLPQADRQAWTSLAAAQIAVAIVEVCLSPTVQVFPRSDPTEFPMLASNTPIIPQTSSLTPVSTPQAASTVSPDAHHPMTPTSTDQSNIPEADPDAHLIDIRDESYALVLCLSATRPRRSVPEQEHSAIKPLASGLLLKRGTATPNRPLPAFGVDVVALAPPRLAQGQSNWMMPRSPEYVLREVLTWYRGLALLGKLRGIPGCEAGEVPWHVGVVLQSGKALEGFFD
Length1371
PositionKinase
Organismfungal sp. No.11243
KingdomFungi
LineageEukaryota> Fungi.
Aromaticity0.07
Grand average of hydropathy-0.333
Instability index50.20
Isoelectric point5.18
Molecular weight150959.05
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05830
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     320.75|      77|      81|    1209|    1287|       1
---------------------------------------------------------------------------
 1132- 1203 (87.20/46.90)	.......SPSTTWRLIV.AFT..GN..LPQADRQAWTsLAAAQIAVAIVeVCLSPTV..QVFPRSDPTEFPMLASntPIIPQTSSL
 1209- 1287 (125.30/76.53)	PQAASTVSPDAHHPMTP.TSTDQSN..IPEADPDAHL.IDIRDESYALV.LCLSATRprRSVPEQEHSAIKPLAS..GLLLKRGTA
 1292- 1365 (108.25/60.05)	PLPAFGVDVVALAP..PrLAQGQSNwmMPRS.PEYVL.REVLTWYRGLA.L.LGKL...RGIPGCEAGEV.PWHV..GVVLQSGKA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.43|      11|      19|     290|     303|       2
---------------------------------------------------------------------------
  290-  303 (13.94/12.19)	ETAFESAklgAVPL
  312-  322 (19.49/ 8.43)	EDDLESA...TSPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.43|      36|      79|     377|     414|       3
---------------------------------------------------------------------------
  377-  414 (60.24/49.67)	DVATVQPPDRDNADD.DGDlfGDIEGDTFGNPDITDADF
  457-  493 (58.20/40.49)	DMPTFDPDARNSSSDlNGS..KDVRSGTAAILQIQTENF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.50|      13|     395|     219|     231|       4
---------------------------------------------------------------------------
  219-  231 (24.50/12.39)	RLL.RDAPESDTES
  616-  629 (20.00/ 8.81)	RLLnNDSDDSDTES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.00|      22|     549|     515|     538|      13
---------------------------------------------------------------------------
  515-  538 (32.02/31.74)	TPPLSpLIVKDRLFSLGYfPTSQD
 1067- 1088 (38.98/25.74)	TPPLS.LLQEASVLHLAY.GISAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.19|      28|      28|     703|     730|      14
---------------------------------------------------------------------------
  703-  730 (49.91/34.18)	NIAVITQLLAEQPEESRTSLWDMF..DFDG
  732-  761 (40.28/26.01)	DIIEVAQILAANAAISYDKSSEFYtdTFDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.82|      26|     860|      58|      86|      19
---------------------------------------------------------------------------
   58-   86 (40.29/33.39)	SQTETTKPRQMFyvaLSAFVQRGLDLTSR
  922-  947 (44.53/28.13)	SGSPNDTPARML...LSAFKNALLDLSKK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05830 with Med13 domain of Kingdom Fungi
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