<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05814

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMASAPIASASEQPLTSTNPQLGPEPYFTYPTPTPDQLEEELPPYFENENVSLGLVLDRFARKGNHDLRVLLGEVLPQLSIRERPKPIIEYAKTTRQALLKYLAVLRWKTSVDIASTSTGSSVANTAGPASFPTPHSNNDPNDNSPDAFAGKGKSKTQADESVIKGKVTDAKRIAHFMEHQNQQHEVAIEHVKHVTKVVEGLRERNPDLLTALSLLATGTYNRLPASLVDPYLPKPVLTNSAILKVLRRLNRQIRYRLRCLDYLPPELIVEDIKDGRMYARGDGWRAELTVVGFEDTSRWWLTGVEWGWKAKEKGVDDPGGRVTKKFTGEERQGILDIANGEVLPPRELPENEMEVDTVITEDPQVKKSEVVEVVKKTVDAPLVRVYNLLQHLSLSYRLEVLFTQAIALSQGKWRGQLIPEMDREDKTLRLKYWLRERPMQVQRQDSTSIKRPQAPATLPASRQTMVGGIIHITLAEKTTPRSELDNLLSDIACGGLVPSERVLRLELNVKWVVDEAGVGGGLKSGDVMDNSMLHLDPDALSVEDLLHVCTRTHASHLTRSHGTSLLTSPRFLNASSVQPSLQESTDPSARPLTLRVPLPSRYAVSHLLIGVSSFSGLLEVEDEGAKGNDARAERAAMSMKSVNEGKTKLVDDITRLTTAVSSVNKWFINVKY
Length672
PositionTail
OrganismCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cryptococcaceae> Cryptococcus> Cryptococcus neoformans species complex.
Aromaticity0.06
Grand average of hydropathy-0.400
Instability index37.61
Isoelectric point6.77
Molecular weight74662.16
Publications
PubMed=15653466

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05814
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     305.61|      72|     128|     228|     301|       1
---------------------------------------------------------------------------
   43-   95 (44.26/22.22)	...PYFENE...NVSLGLVLDRF...ARKGNHDLRVL...........lgEVLPqlsirerP.KPIIEYAK.TTR..........................
  228-  301 (120.68/80.32)	VD.PYLPKPVLTNSAILKVLRRL...NRQIRYRLRCL.............DYLP.......P.ELIVEDIK.DGRMYARGDGWRAEltVVGF.EDTSRWWL
  304-  382 (87.83/52.47)	VEwGWKAKEKGVDDPGGRVTKKFtgeERQGILDIANG.............EVLP.......PrELPENEMEvDTVITEDPQVKKSE..VVEVvKKTVDAPL
  383-  434 (52.84/28.61)	VR.VY............NLLQHL...S..LSYRLEVLftqaialsqgkwrGQLI.......P.EMDRED.K.TLRL.....................KYWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     207.27|      67|     352|     159|     226|       2
---------------------------------------------------------------------------
  159-  226 (105.27/69.90)	DESVIKGKVTDAKRIAHFMEHQNQQhEVAIEHVKHV...TKVVEGLRERNPDLLTALSLL.ATGTYNRLPAS
  514-  584 (102.01/62.95)	DEAGVGGGLKSGDVMDNSMLHLDPD.ALSVEDLLHVctrTHASHLTRSHGTSLLTSPRFLnASSVQPSLQES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.03|      10|      15|      15|      24|       3
---------------------------------------------------------------------------
   15-   24 (19.14/11.16)	TSTNPQLGPE
   31-   40 (18.89/10.91)	TPTPDQLEEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.54|      11|     326|     121|     132|       5
---------------------------------------------------------------------------
  121-  131 (18.54/12.05)	SVANTAGPASF
  138-  148 (21.00/ 7.93)	NDPNDNSPDAF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05814 with Med14 domain of Kingdom Fungi
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