Description | Mediator of RNA polymerase II transcription subunit 6 |
Sequence | MQRLTLEHLNQMVGIEYILLHAQEPILFIIRKQQRQSPAQVIPLADYYIIAGVIYQAPDLGSVINSRVLTAVHGIQSAFDEAMSYCRYHPSKGYWWHFKDHEEQEKVKPKAKRKEEPSSIFQRQRVDALLIDLRQKFPPRFVQQKSGEKPVPVDQAKKEAEPLPETVKSEEKESTKNIQQTVSTKGPPEKRMRLQ |
Length | 195 |
Position | Head |
Organism | Mus musculus (Mouse) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Mus> Mus. |
Aromaticity | 0.08 |
Grand average of hydropathy | -0.701 |
Instability index | 57.00 |
Isoelectric point | 9.32 |
Molecular weight | 22642.78 |
Publications | PubMed=19468303 PubMed=23806337 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 PIRNR:PIRNR023869 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP05811 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 69.76| 21| 42| 97| 117| 1 --------------------------------------------------------------------------- 97- 117 (37.58/18.85) HFKDHEEQEKVKP..KAKRKEEP 140- 162 (32.18/15.34) RFVQQKSGEKPVPvdQAKKEAEP --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) PPEKRMRL 2) TKNIQQTVST 3) VDALLIDLRQKFPPRFVQ 4) VDQAKKEAEPLPETVKSEEK | 187 175 126 153 | 194 184 143 172 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab