<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05810

Description Mediator of RNA polymerase II transcription subunit 25
SequenceMDPTSKSGLNQVSDVVFVIEGTANLGPYFESLRNNYILPTIEYFNGGPPAETDFGGDYGGTQYGLVVFNTVDCAPESYVQCHAPTSSAFEFVSWIDSIQFMGGGAESCSLIAEGLSVALQLFDDFKKMREQIGQTHKVCVLLCNSPPYLLPAVESVSYTGCTADSLVQIIRDRGIHFSVIAPRKLPALRSLFERASSVAGPPESSHPDYSQDPFHMVLVRGIALPVAPGGGSVPVSLKPVLPPQSLPVNQNPLVPVASTAPQMNTFQNVSLHAAHDAAQKALEEAANQQQKNRFGQISTPPFSQSPVLPPGGKPSLSTVTTVSPPVLTQQQVPPQQPQQQTQVPQPGLPAVNQQPPQASQQQPNNQQTPPPTQPGMAAVPAPPPGAQQGVANKVVAWSGVLEWQEKPKASSMDSNTKLTRSLPCQVQVSQGENLNTDQWPQKLIMQLIPQQLLVNINIHFNPVFKCNREVVWIGTYFDMMYILCLYVCMCAGCVHFPHSAPCEVRVLMLLYSSRKRIFMGLIPNDQSGFVNGIRQVITNHKQVQQQRSMQPGQVQPNQNFLNRPPGPIPVTHGNVPQQSVVVGLPSVSQVTLMEDQQRQNNMLRAAATGNQQAPVTGAPPNQVQGQAQAPGGGMLRLQNPGANPQLRSLLLSQQPVSVRQVLGLHNISFQHCQMVHAAPGGGAQMQPQWRQPHQGPLMVPTGPRGPVTQNPGMPSVSSVMEDEILMDLI
Length729
PositionUnknown
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Cypriniformes> Danionidae> Danioninae> Danio.
Aromaticity0.06
Grand average of hydropathy-0.247
Instability index56.37
Isoelectric point6.95
Molecular weight78834.09
Publications
PubMed=23594743

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05810
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     514.60|      64|     126|     533|     596|       1
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  131-  173 (32.20/ 6.39)	.........................QIGQTH.....KVCVL.LcN.S....P..P..YLLPAV........ESV...sYTGCTADSLVQIIRDR
  188-  262 (57.57/17.80)	LRSLFERASS..V.....AgPPESSHPDYSQ....dPFHMV.L.V.RgialPvaPggGSVPVSLKP.VlPPQSL....PVNQNPLVPVASTAPQ
  266-  320 (57.41/17.73)	FQNVSLHAAH..D.....A.AQKALEEAANQ.....QQKNR.F.G.Q....I..S..TP.PFSQSP.VlPPG........GKPSLSTVT.....
  322-  353 (41.96/10.78)	VSPPVLTQQQ..V.....P.PQQPQQQTQ......................................V.PQP........GLPAVNQ.......
  358-  404 (51.68/15.15)	............A.....S.QQ...QPNNQQ..tppPTQPG.M.A.A....V..P..APPP...G....AQQGV....ANKVVAWSGV..LEWQ
  416-  462 (47.68/13.35)	............T.....K.LTRSL.PCQVQ.....VSQGEnL.N.T....D..Q..WPQKLIMQL.I.PQQLL....V.......NINIHFNP
  533-  596 (112.21/42.39)	IRQVITNHKQ..V.....Q.QQRSMQPGQVQ.....PNQNF.L.N.R....P..P..GPIPVTHGN.V.PQQSV....VVGLPSVSQVTLMEDQ
  603-  668 (43.38/11.42)	LRAAATGNQQapV.....T....GAPPNQVQgqaqaPGGGM.L.RlQ....N..P..GANPQLRSLlL.SQQPVsvrqVLGLHNIS........
  670-  723 (70.52/23.63)	......QHCQ..MvhaapG.GGAQMQPQWRQ.....PHQGP.L.M.V....P..T..GP....RGP.V.TQNP.......GMPSVSSV..MEDE
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05810 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LPVNQNPLVPVASTAPQMNTFQNVSLHAAHDAAQKALEEAANQQQKNRFGQISTPPFSQSPVLPPGGKPSLSTVTTVSPPVLTQQQVPPQQPQQQTQVPQPGLPAVNQQPPQASQQQPNNQQTPPPTQPGMAAVPAPPPGAQQGVA
2) QMVHAAPGGGAQMQPQWRQPHQGPLMVPTGPRGPVTQNPGMPSVSSV
3) TLMEDQQRQNNMLRAAATGNQQAPVTGAPPNQVQGQAQAPGGGMLRLQNPGANPQLRSLL
246
673
591
391
719
650










Molecular Recognition Features






MoRF SequenceStartStop




NANANA