<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05807

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMMAAFGVLSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNSSKISSNFSSIIAEKLRCNTFPDTGKRKPQVNQKDNFWLVTARSQSSINNWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYSVPVMRSAWMIKMTCAYHAAITENKMKKRHVIDPCIEWTQIITKYLWEQLQKVAEFYRQSPSQGCGSPLPAPPAEVETAMKQWEYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLRLLLPLLLQYSGEFVQSAYLSRRLAYFCTRRLNLLLSDGSIGPGPGGHQAHGISAQQGNALPPTPTSQPAGGNQPQTPFTDFYICPQHRPVVFGLSCMLQSIVLCCPSALVWHYSLTDSRNKTGSPLDLLPIAPSNLPMPGGNSTFNQQVRAKVREIEEQIKERGQAVEFRWSFDKCQETTAGFTISRVLHTLEVLDNHSFEKSDFSNSLDSLYNRIFGSGQSKDGHEMSPDDDAVVTLLCEWAVSCKRSGPHRAMVVAKLLEKRQTEIEAERCGESEVVDEKGSVSSGSLSAATLPVFQDVLLQFLDTQAPVLTEPGNESERVEFSNLVLLFYELIRHDVFSHNIYMCTLISRGDLASNSHLPRPRSPSDEPSDESERKDQDAGSSVKIEDTGMSESMEIDHNSSANFDEMFSPPMHCESKGSPSPEKQAQEQESKSTAKDKGMDPAFPLVYEQPRHIQYATHFPIPQEESASHECNQRLVVLYGVGKQRDEARHAIKKITKDILKVLNRKSTAETGGEEGQKRKRSKPEAFPTAEDIFSKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHIQFIFDLMEYSLNISGLIDFAIQLLNELSLVEAELLLKSSNLAGSYTTGLCLCIVAVLRRYHSCLILNPDQTAQVFDGLRIVVKSGVNPADCSSAERCILAYLYDLYTSCSHLKSKFGEIFSEFCSKVKNSIYYNIDPSDSNMLWDQMFMIDAITNPTAHNLNHSMLGKITNELNDSPANRYSFVCNVLMDVCVDHRDPERVNDIGILCAELTAYCRSLSAEWLGVLKALCCSSNNGNCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLVRCVAIPSLLNAACSEQDSEPGARLTCRILLHLFRTPQRNPCPQDGTKSDKSIVGIRSSCDRHLLAASQNSIVVGAVFAVLKAVFMLGDAELKGSGFSHPAGLDDIGEDDMGSKKSGGRNVSIETASLVVYAKYVLKSICHQEWVGERCLKSLSEDSSALQDPVLVNIQAQRLLQLICYPHRQLDSEEGDNPQRQRIKRILQNMDQWTMRQSSLELQLMIKQSSNNELYSLLENIAKATIEVFQKSAEMNSSNPSWNGSAVSGSSVSNSNSASKLKPVLSSSERSGVWLVAPLIGKLPTSVQGHVLKAAGEELEKGQHLGPSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVQQIVTNWREDQYQDDCKAKQMMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSESLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFEKEGLQVSTKQKISPWDVFEGLKHSAPLSWGWFGTIRVDRKVTKFEEQQRLLLYHTHIKPKQRSYYLAPLNLPQEEEEPLTPVPPEPDKKLDTAKVEKSVSNVPTKKKKKKPASTVKQEDYKPHNTVMQYAPGMTPDLPLSMGQTNMSYRMGYQAPMNMYAQNQPLPPGGPGLEPPFRPRVPMNKMPPRPNYTMPNMQTAGMGNLMGMEKQYQMNYKPMPNMAQGQMLRHQLQGHNHLIGQQIRQVTPNPQYSSMQPAQNIPQGYTSYGSHMGMQPHPSQTPGMVPNSYGNQGFQTGHPATNPTMVDSIRQMQQRPGYVHQQAPAAYGHTIQSTQRFPHQSMQQTPMMHGLAQSHLGVQGIHPNMRPNQMMEQQQQQQQQQQQQQQQQQQQQVHQQQQHIRQGPVFRPQQQQQVQQQVQQQVQQQQVQQQQVQQQVQPQQVQQQQVQQQQQQVSAAQPPAQALGMQALPPQQPMFQRQGMQQTQQQQQTAALVRQLQQQLSSTQPAQNNSSYY
Length2175
PositionKinase
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Cypriniformes> Danionidae> Danioninae> Danio.
Aromaticity0.07
Grand average of hydropathy-0.535
Instability index56.03
Isoelectric point6.90
Molecular weight244261.58
Publications
PubMed=23594743

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05807
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     164.07|      16|      16|    2072|    2087|       1
---------------------------------------------------------------------------
 1873- 1887 (21.67/ 6.26)	Q...YQMNYKP.M..PNMAQG
 2031- 2048 (26.47/ 9.52)	QmmeQQQ.QQQ.QQ.QQQQQQ
 2051- 2065 (30.63/12.35)	Q...QQQVHQQ..Q.QHIRQG
 2072- 2087 (32.80/13.82)	Q...QQQVQQQ.VQ.QQVQQQ
 2090- 2106 (28.40/10.83)	Q...QQQVQQQ.VQpQQVQQQ
 2133- 2149 (24.10/ 7.91)	Q...QPMFQRQgMQ.QTQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     281.98|      44|      94|    1818|    1861|       2
---------------------------------------------------------------------------
 1731- 1778 (32.06/10.78)	........PLNL.PQEeeEPLTP..VPP.....EPDKKldtakveksvSNVPTKKKKKKPASTV
 1779- 1817 (56.96/25.53)	KQ..EDYkPHNTVMQY..........AP...GMTPDLP..........LSMGQTNMSYRMGYQA
 1818- 1856 (74.59/35.98)	P........MNMYAQN..QPLPP..GGP...GLEPPFR..........PRVPMNKMPPRPNYTM
 1924- 1967 (76.77/37.28)	PQ..GYT.SYGSHMGM..QPHPS..QTP...GMVPNSY..........GNQGFQTGHPATNPTM
 1986- 2029 (41.61/16.44)	PAayGHT.IQST..QR..FPHQSmqQTPmmhGLAQ.............SHLGVQGIHPNMRP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     235.03|      69|      94|     305|     377|       3
---------------------------------------------------------------------------
  305-  377 (118.89/69.52)	LNLLLSDGSIGPGPGGHQAHGisaQQGNALPPTPTSQPAGGNQPQTPFTDFYICpQHRPVVFGLSCMLQSI.VL
  400-  469 (116.15/58.36)	LDLLPIAPSNLPMPGGNSTFN...QQVRAKVREIEEQIKERGQAVEFRWSFDKC.QETTAGFTISRVLHTLeVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.44|      18|      95|     693|     715|       4
---------------------------------------------------------------------------
  646-  665 (26.27/ 8.26)	PSDESERKDQDAGSSVKieD
  698-  715 (31.17/12.25)	PSPEKQAQEQESKSTAK..D
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     150.04|      41|      57|    1173|    1225|       5
---------------------------------------------------------------------------
 1173- 1215 (63.03/42.85)	PCPQD..GTKSDKSIVGIRSSCDRHlLAASQNSIVVGAVFaVLKA
 1232- 1270 (61.88/48.00)	PAGLD..DIGEDD..MGSKKSGGRN.VSIETASLVVYAKY.VLKS
 1272- 1298 (25.13/ 7.55)	.CHQEwvGERCLKSL.....SEDS...SALQDPVLV.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     181.38|      54|      57|     991|    1047|       6
---------------------------------------------------------------------------
  991- 1047 (88.49/72.04)	IDPSDSNMLWDQMFMIDAITnPTAHNLNHSMLGKITNELNDSPANRYSF...VCNVlmDV
 1049- 1105 (92.89/63.87)	VDHRDPERVNDIGILCAELT.AYCRSLSAEWLGVLKALCCSSNNGNCGFndlLCNV..DV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     175.38|      58|     179|    1425|    1496|       7
---------------------------------------------------------------------------
 1425- 1496 (81.66/91.62)	LIGKLPTSVQGHvlkaAGEELEKGQHLGPSSRKERDrqkqksmsLLSQQPFLSLVLTclKGQ...DEQREGLLTS
 1610- 1670 (93.72/66.62)	LVKKLRKELGDR....QSESLEKVRQLLPLPKQTRD........VITCEPQGSLIDT..KGNkiaGFEKEGLQVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.43|      13|      30|     842|     854|       8
---------------------------------------------------------------------------
  842-  854 (23.88/17.04)	FALGMSYHLPLVQ
  875-  887 (18.55/11.23)	FAIQLLNELSLVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.46|      12|      31|    1123|    1134|       9
---------------------------------------------------------------------------
 1123- 1134 (21.26/13.09)	AR.QCLLLEDLVR
 1155- 1167 (18.20/10.12)	ARlTCRILLHLFR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.30|      11|      31|     947|     960|      10
---------------------------------------------------------------------------
  947-  960 (13.73/19.24)	CSSAERCIlaYlYD
  980-  990 (21.58/13.42)	CSKVKNSI..Y.YN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     188.12|      65|    1322|      31|     106|      11
---------------------------------------------------------------------------
   31-  106 (96.62/92.01)	KQ.KEDELTAL..NVKQGFNNQPAVSGDEHGSakNVNFNSSKIS.SNFS.SIIAEKLRcntfPDTGKrkpqvNQKDNFWLV
 1353- 1422 (91.49/59.73)	KQsSNNELYSLleNIAKATIEVFQKSAEMNSS..NPSWNGSAVSgSSVSnSNSASKLK....PVLSS.....SERSGVWLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.42|      13|      50|    2108|    2120|      13
---------------------------------------------------------------------------
 1904- 1921 (20.18/ 7.85)	QIRQvtpnpQYSSMQPAQ
 2157- 2169 (25.23/11.79)	QLQQ.....QLSSTQPAQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05807 with Med12 domain of Kingdom Metazoa
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