<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05790

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSVGGLVTPRPRPVQLSLLIEFMCQKTYTDLMRLVDLLPSKTDLEKKIELAKFFSRTRNLFIRLEALTKWANTSSKVDKCEKISNFLEEQSMLLLDTANILSVLHQNHLISARLPPFAMLLAIDIFVNKTYTRLPKAIKVRFTPPEPISNEEIRMGLPDLNRIIKYRLSVSPCPRRFTSIVIEHGRVIFTVPHEFEVTLTLLSEALDFPWSIIGIKFLVSDPSRSSSGPLIHPQQTRFLLQHAQSRILDPRFDKRPPLTHLYDMLHAFAMSLQLDVLFEQAQRLRSRRPTDPFSIEDYRPGQLLKVVYWRGLSNCNYQAVMGPDGKMRQTIYSIVIHVSPLDPQRPLCVTHHPDLNTIDAHKIGSFVQGGCLSIENLLTRTIIVRAERMLTEIKHELLPLSPGPITIGEIPLSLSVPVLWPCHPHEILQLRINTAQGQVRASFPSSDPIRSAPLLRELELAFNRPSARRVALDRTSAIDCRAGSRGIRGLVGDDTRWQARLVEVFSRLRCLLGQWRVRWANRGRLVRYSLPLSVSPPSSTAPQPGYVEVLERARQDRVALAFIKLFPNDEYYLLCEVAPTDALAVGYRHYLLKCVPVPITVTDLHVAPGGRWLTHNSEQSAMDGAGVTASPGVALRITHFMPLIGEETFANLVGQAVYSSLILQPSLDELREAAAQVQRNQVCRRLKRVRALLEHLSGNEESSSASEAKRRCMERLQPNERAMLLSATDRFTTTSSSTVLMPDLSRLLAALENDVIANELNVKLAEHGITHYGVVNNAQSDILNINIRSIPTKRLPTWARPGIALLHHYARRVVIISSSRLSSSTPASAASASASMRCWRLTIAFSGLPGNVNGGELLYQSPMAQVNSLSDLNSFLLSVITEWEALCRLFAICGPVIENPASLPPDVGLNGFDAKSLILAYGPGQHYLAELTIDSRQNCCLRLGVHPGPVTLKHDGCADDALKQRCQRQRQRDLFENPHCIVREHLEFLIESQKSLLPMCSAFSMLRRFSPNQVLSSTLDFMMSMEVLRKPTIMTNSAKSSAIVKSSRPIRSMALIALSCFDLLLAYRGTLCMRFKLKTDQAATVLISDGCHHQEVGGAPPQSRGGGISSEIYPVQGFVPLPAFQLFLESMQKALKMEGRGENPSGGFTMLQLDRILRPSGGGINGPVSPSALECYLSASLTFHAAFQAVNTHRWQVPSAPALEVGEFVAKAPDSGLEVRLKMEEEATAMMAGVPRWRLVLRVTPDPVSCSVEGVTEMGARIEEFFRRRVCSVSPQAAAITSFFRLLSVPGSTLFDLVSNVFAWDLDSASGVNNGLPIFRIGLVSLATPAVPEPSVVLRSPSYLAMQVIIPRASAFNEQSSPSGLLRASSVEVVGLTYDWSKNHVAIVASKRFQGLDEIINQRFKATRACTLVQLISHMRKNQLQQGMPMQQQAQVQQ
Length1438
PositionTail
OrganismHydatigena taeniaeformis (Feline tapeworm) (Taenia taeniaeformis)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Cestoda> Eucestoda> Cyclophyllidea> Taeniidae> Hydatigera.
Aromaticity0.07
Grand average of hydropathy-0.038
Instability index53.60
Isoelectric point9.23
Molecular weight159769.30
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05790
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.80|      32|      75|     659|     695|       1
---------------------------------------------------------------------------
  659-  695 (39.87/38.35)	SSLILQPSLDELreaAAQVQRNQVCRRLKrVRaLLEH
  736-  767 (51.93/30.80)	SSTVLMPDLSRL...LAALENDVIANELN.VK.LAEH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.35|      12|      15|    1260|    1273|       2
---------------------------------------------------------------------------
 1260- 1273 (18.30/16.38)	ARIEEFFrrRVCSV
 1278- 1289 (21.06/11.27)	AAITSFF..RLLSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     138.71|      32|      75|     420|     454|       3
---------------------------------------------------------------------------
  192-  230 (34.59/13.37)	.PHEfevtltLLSEALDFPWSIIGIKFLVSDPSRSSsgPL
  232-  258 (46.97/18.44)	HPQ.........QTRFLLQHAQSRILDPRFD..KRP..PL
  423-  454 (57.15/33.56)	HPHE......ILQLRINTAQGQVRASFPSSDPIRSA..PL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     182.54|      60|     193|     296|     409|       5
---------------------------------------------------------------------------
  296-  364 (95.19/61.97)	EDYRPGQLLKVVYWRglSNC...NYQAVMGPDGKMRQtiYSIVIHVSPLDPQRP...............................LCvthhpDLNTIDAHKIG
  493-  586 (87.35/20.73)	DDTRWQARLVEVFSR..LRCllgQWRVRWANRGRLVR..YSLPLSVSPPSSTAPqpgyvevlerarqdrvalafiklfpndeyylLC.....EVAPTDALAVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.01|      24|    1099|       2|      26|       9
---------------------------------------------------------------------------
    2-   26 (39.47/31.62)	SVGGLVTPRPRPVQ.......LSLLIEFMcQK
 1103- 1133 (37.54/23.53)	SRGGGISSEIYPVQgfvplpaFQLFLESM.QK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.32|      24|      25|      71|      94|      10
---------------------------------------------------------------------------
   71-   94 (39.98/28.23)	ANTSSKVDKCEKISNFLEEQSMLL
   98-  121 (38.35/26.76)	ANILSVLHQNHLISARLPPFAMLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05790 with Med14 domain of Kingdom Metazoa
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