<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05777

Description Mediator of RNA polymerase II transcription subunit 18
SequenceMSRKGLTIMPGAVVTSECDIQGDITVGTRTVIHPKARIIAEAGPIRIGESNLIEEQVEIINSVPNTILIVGDFNVFEVGAQVHSREVGNSNVFESKCFVGPQVRISNGCVIGAMCSLTAPEQLPENTIVFGEGCLRRVATERPMPQTLQLDFLSKILPNYHHLLMVSRPSVSSIKVRDRSPNYYLVPTLLAELMDSQQYQLPGTAVPRKPSVMSAPQHQQQPQQQQQPVVMQQQQQQTQMMPLGQEAFAFEPLEGQAIPSALLEQQTRAPEPFAGSSSQARGATMQEVFIQGVAAVSQVDLLTARLRGLCREQAVFLDHEEAFSVPLVNAQSTNPVASASGTTPFVHLRARRSVLPNARELGLWPVLRYLGSVESGDRVCRRSYLEACVNGPLVGFLKSIGFKKDFEFIAEGEVYVRGRAKVLIYAVFEVVYPNSGDMQMSLPSKGRNVAPNSLMVEVSAVGSPADDTLQREVAELMELLHPLVIPGRVDHARLACR
Length497
PositionHead
OrganismTaenia asiatica (Asian tapeworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Cestoda> Eucestoda> Cyclophyllidea> Taeniidae> Taenia.
Aromaticity0.06
Grand average of hydropathy-0.072
Instability index51.35
Isoelectric point6.19
Molecular weight54426.93
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
cytoplasm	GO:0005737	IEA:UniProtKB-KW
dynactin complex	GO:0005869	IEA:InterPro
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05777
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.96|      17|      17|     209|     225|       2
---------------------------------------------------------------------------
  209-  225 (33.27/17.87)	KPSVMSAPQHQQQ..PQQQ
  227-  245 (27.69/13.75)	QPVVMQQQQQQTQmmPLGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.66|      18|      20|      22|      39|       3
---------------------------------------------------------------------------
   22-   39 (30.87/20.13)	GDITVGTRTVIHPKARII
   43-   60 (28.78/18.32)	GPIRIGESNLIEEQVEII
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.77|      16|      17|      97|     112|       4
---------------------------------------------------------------------------
   97-  112 (30.83/19.56)	C.FVGPQVRISNGCVIG
  115-  131 (24.94/14.44)	CsLTAPEQLPENTIVFG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.93|      24|      25|     281|     305|       6
---------------------------------------------------------------------------
  281-  305 (35.81/28.96)	RG.ATMQEVFIQGVAAVSqVDLLTAR
  307-  331 (39.11/26.44)	RGlCREQAVFLDHEEAFS.VPLVNAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.69|      20|      27|     351|     373|       8
---------------------------------------------------------------------------
  351-  373 (25.88/27.54)	RRSVLpNARELGlwPVLRYLGSV
  381-  400 (36.80/22.62)	RRSYL.EACVNG..PLVGFLKSI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05777 with Med18 domain of Kingdom Metazoa
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