<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05775

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTDQYPRLDGRSLEDSHTNIFALTDLSGIHYRIYIPKNDGNYSIYDDPLLSAYNNCLRENLMCAWVRRKRVGTEPHKPDIYSNFSKELWVFWYGSDDPCTRSRDRLISSDLEEISSGNWGNGLTYETRCVLFKALHNVIERYLLNKGYVRLGKWFLQPCNSQSIRDKAQYSINFSFFLHGESTVCASLDIRRFPKFKSLTPRILSFCEKSGGRFSVVLAPYGITAHLVVPSQAHTNDAFVDKELELWKRFFPIRSPGGNCTHLNSSAHQNSFYLDLLTPNKSSPAQQQQQCPRPDASLKRSSASYTEQLPEFVDVLIGGFRMRYPTCFVLIAEDQLTSITEHLQDGPERRLTLPPKSRQTTSESYGFPHPRLPLKQLPSTKRRVYLATRALQRALRFERSFVPELDCFHVRSRLPTQSTVDEAVFKTNSEAKSPQIVLPLHRRSDSISRMLCAFVSEIDASLGNGGGGNSDVPISSLRRQPSSTDPLMPKLSPQPSNPVVFGVGGVSAAANDSHSASNSVAVAASSFQTTHHIGAAKPPCLFNSQLINPRESGPTHSKPKPMDWNETFVSSIAPKLPRCVVRIPQAPTQQTKPLPPSTVKPEVTGSETSWLARQVVHQCRRPPTIHLSYLDQVNYLEHSSTSFGEEFILQPRHQCHPQMPSGHQYGCAIGVIMDMYGVNNDSQVFQQQQHHFCQASHPYCKQDQPYSTKDLDTYTHDSLVPESFHHTLGEEIYGPNFKPEGPLKSSCLMRNQMRHTSVRSLLSSSGSGHLGPAELAAMYPTPPPFEITLSAGSSGSCPQLSPTEVKPLLPCPSETDFLYPEEGNLRQKESLTNAIVQSILHNTRPLFDQEVVCFHREWQFMCPPSVQIPFSAKFKLTPEELHQYREVDVTLRPTRGFEPASGPTNGQHDGLFLHLPRRLPYPPQRPNHHPSRGHSQVDYTALATEPDSSTFDLDELRGSDALKVNIILSDSLLNLFKDHNFDSCNICECATSILGMEIDVYVSAPSPAPTRSCNCGFSALVNRKFALAGNLFWEDEVEVASLSIASVDVAKLRPRKPPPSRAATTACLPVLTQWMRGPLEEFGVRFLVEWLQSVETATSVTEVRQGTVEKDALYDYNDVCALTASALEQSACDLSSLAEAMMGGCSPRENAMTKHLRLDEATRKEGVGFHPAVFRQLPSDLPSNKNDQIRLLGSVRLWLQEAIDQLESTYKVEGPLTWKAFHQLAGRGHSESSKAQPIPQFRVGGGLKNGNTNVLISPFSVRDWDHLSLTPLSRPKRVAFAVVLPSWQSHGVSPVGLESQRRSVETLSTFFYELSSAFENCLFGQHYPYYQPKAGNPDSAFIHVQCSFPYKDENDLSSGFSPVNARQSRRRQQSGSSGTHLTDALLFSLQRYKSGAIHAVRKALSERGVALPDGSCSSILAPFAGMQDMAPSVPPVILSKISPLNGQGPLTTAFDPNADSQYDVTLVIYLIDPFTQAIMGDESRNLTTRCLAETAGRMTAQLPASWRQRVSVQLLPMSHIISPRCGVVGREDGGDAGLLSHIKSMALAVYTSIDRVISPSLINANRTLTGMGPAADKEVISANFQKDHTHRVYAPAYTLAQSHDLWGQWDVHPAEPLQPSSVLFVSYCLSEDLQWLLATCTDQYGTLAQQTFINIGAPEFICAPSGQSAAGTGTDGFHVSTRRLALARLWDFIISVIATSSNPWRLVVGRLGRLGHGELKGWCGFLSRKNLQNVNRSLRANCALCNVITLTPATMSNNGPTYRGKSTATINLTADSRVPNTCVHETPSLISACLVSTEPQSTFRLFPGSDLNTGDLGGSSSHGGGGHGGGSGGGGGGGGGGGSASVSGGGAGVAGGPAGQASAGPFSNGVISAAGYAPSTTHILVFPTSTSAQAQSEQDDINFTEIFSELYEDNDLDDHTTVNMPSLDTLTTPTSAGPGCNLANVVVGVVGGGGSCSGVVQDPNGVGTGQLMPMTRTGIPAEPNIHGMPYEVACRERAKYFLDALLPFGVPDPQSEKPSLMQQPLALGYYVSTAPVGPLPTWFWAACQQTRRNSPVCLKSSLHLHCTLVGVDDDAAANGGQQCPSSNSATAGGHLLDSSVTCDVLRFVLECYNALSWLSYDPCINDRRSCLPVHMLSLAQLYQAAKAFI
Length2149
PositionMiddle
OrganismTaenia asiatica (Asian tapeworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Cestoda> Eucestoda> Cyclophyllidea> Taeniidae> Taenia.
Aromaticity0.08
Grand average of hydropathy-0.303
Instability index55.41
Isoelectric point6.62
Molecular weight234818.19
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05775
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.18|      14|      18|    1422|    1435|       1
---------------------------------------------------------------------------
 1422- 1435 (27.25/13.30)	PFAGMQDMAPSVPP
 1443- 1456 (25.92/12.26)	PLNGQGPLTTAFDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.24|      15|      19|    1823|    1839|       2
---------------------------------------------------------------------------
 1823- 1837 (34.44/10.57)	GGGGHGGGSGGGGG.G
 1839- 1854 (25.80/10.92)	GGGGSASVSGGGAGvA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.08|      12|      19|    1958|    1973|       3
---------------------------------------------------------------------------
 1958- 1973 (19.51/18.03)	GVVQDPNGVGtgqlMP
 1978- 1989 (25.57/12.55)	GIPAEPNIHG....MP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.03|      44|     325|     457|     500|       4
---------------------------------------------------------------------------
  457-  500 (80.52/36.99)	EIDASLGNGGGGNSDVP..ISSLRRQPSSTDPLMPK...LSPQPS..NPVV
  786-  836 (65.51/28.77)	EITLSAGSSGSCPQLSPteVKPLLPCPSETDFLYPEegnLRQKESltNAIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     299.21|      79|     325|    1700|    1782|       5
---------------------------------------------------------------------------
 1525- 1598 (50.71/22.42)	.......................CGVVGREDggdaglLSHIkSMALAVYTSIDRVIspSLINAnrTLTGMG.PA.....ADKEVISANFQKDhtHRVyaPA..YT
 1602- 1685 (115.44/63.18)	SHDLW....GQWDVHPAEPLQPSSVLFVSYC......LSED.LQWLLATCT.DQYG..TLAQQ..TFINIGaPEFicapSGQSAAGTG.TDG..FHV..STrrLA
 1700- 1782 (133.07/81.41)	SSNPWrlvvGRLGRLGHGELKGWCGFLSRKN......LQNV.NRSLRANCALCNVI..TLTPA..TMSNNG.PTY....RGKSTATINLTAD..SRV..PN..TC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.36|      27|     325|     278|     308|       7
---------------------------------------------------------------------------
  278-  308 (45.05/31.83)	TPNKSSPAQQQ..QQCPRPDAslkrSSASYTEQ
  604-  632 (47.31/24.93)	TGSETSWLARQvvHQCRRPPT....IHLSYLDQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.17|      35|    1300|      11|      45|      16
---------------------------------------------------------------------------
   11-   45 (64.37/46.88)	RSLEDSHTNIFALTD.....LSGIHYRIYIPKNDGNYSIY
 1302- 1341 (59.80/42.88)	RSVETLSTFFYELSSafencLFGQHYPYYQPKAGNPDSAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.01|      29|    1300|     505|     533|      17
---------------------------------------------------------------------------
  505-  533 (48.74/27.24)	GVSAAANDSHSASNSVAVAASSFQTTHHI
 1855- 1883 (52.27/29.79)	GGPAGQASAGPFSNGVISAAGYAPSTTHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.61|      33|    1300|     705|     743|      19
---------------------------------------------------------------------------
  705-  743 (47.58/41.66)	PYSTKDLDTyTHDSLVPESFhhTLGeeiYGPNFKPEGPL
 2007- 2039 (62.04/33.44)	PFGVPDPQS.EKPSLMQQPL..ALG...YYVSTAPVGPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.66|      44|    1067|     180|     230|      20
---------------------------------------------------------------------------
  180-  230 (60.88/61.14)	GESTVCAS.LDIRRFPKFkSLTPriLSFCEKSGgrFSVVLAPYgiTAHLVVP
 1250- 1294 (76.78/48.96)	GNTNVLISpFSVRDWDHL.SLTP..LSRPKRVA..FAVVLPSW..QSHGVSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.79|      41|    1300|     116|     161|      21
---------------------------------------------------------------------------
  116-  161 (62.46/63.67)	SGNWGNGLTYETRCVL..FK..ALHnVIERYLLNKGyVRLGKwflQPCNS
 1374- 1418 (61.33/41.34)	SGSSGTHLTDALLFSLqrYKsgAIH.AVRKALSERG.VALPD...GSCSS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05775 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EHLQDGPERRLTLPPKSRQTTSESYGFPHPRLP
2) GGGGNSDVPISSLRRQPSSTDPLMPKLSPQPS
3) RLFPGSDLNTGDLGGSSSHGGGGHGGGSGGGGGGGGGGGSASVSGGGAGVAGGPAGQASAG
341
465
1804
373
496
1864










Molecular Recognition Features






MoRF SequenceStartStop




NANANA