<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05758

Description Uncharacterized protein
SequenceMADRLTELQDAINLQAQNLCNAVGVIQQIAQPSFFSELNYNGRIEKEWTSNPEFQALLQSQNQEDISHKFAVSIAATAKQIELLINSLPAEEASLEIQDEATRQLLSEYRRESAKLVHLITKSFQQRLSKVRQLLSQIAETQLLTRTIESEVGYAGCYIPVFLVLPILKKCTTISIMESPKMTMATEEVYSTWLSHLSFSLIAIIVSRLVGLFLPIVLPKLATIILPSCRARHTAFMQTEKEIRDLRRQMSQLNMVDNFASYSKLERKLKVLERQQAACERSQLGTTVVSSLVAQCLRYALQGILIGWLVFQSPCVRLTEDQVAASREARAFYNQIPVGWLVVVVHYIPSCVLLMAWVALCEAAASFIVSYVQRKIEC
Length378
PositionMiddle
OrganismMesocestoides corti
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Cestoda> Eucestoda> Cyclophyllidea> Mesocestoididae> Mesocestoides.
Aromaticity0.07
Grand average of hydropathy0.145
Instability index58.13
Isoelectric point8.00
Molecular weight42688.26
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 

Receptor for GET3/TRC40-mediated insertion of tail-anchored
(TA) proteins into the ER membrane. 


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
GO - Biological Process
tail-anchored membrane protein insertion into ER membrane	GO:0071816	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05758
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.69|      31|      35|     298|     332|       1
---------------------------------------------------------------------------
  299-  332 (48.04/46.73)	YalQGILIGWLV....FQSPCVrLTEDQVAASREARAF
  333-  367 (54.65/35.09)	Y..NQIPVGWLVvvvhYIPSCV.LLMAWVALCEAAASF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.55|      20|      34|      43|      62|       2
---------------------------------------------------------------------------
   43-   62 (36.85/20.69)	RIEKEWTSNPEFQALLQSQN
   80-   99 (30.71/16.28)	QIELLINSLPAEEASLEIQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.27|      30|      50|     159|     188|       3
---------------------------------------------------------------------------
  159-  188 (52.23/31.06)	IPVFL..VLPILKKCTTISIMESPKMTMATEE
  210-  241 (47.04/27.40)	VGLFLpiVLPKLATIILPSCRARHTAFMQTEK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05758 with Med21 domain of Kingdom Metazoa
Unable to open file!