Description | Mediator of RNA polymerase II transcription subunit 6 |
Sequence | MDSSKNNEPSPYEILWQDPVFPAHQLNASNVLQYFSNLSNPFYDRESNNEVVRMQGLGLDRLASLFGIEYCLCYYQEPSLFVIRKQDRISPSEVMPLAYYYVINGVVRQCPDLGTLINSRIHSITANLNKIIQELAPCARFHPSDGSYSWQNPEVETTETLKVVKKKPADFIATNPYQVNRTDFLLNEWASRFPPMQLQTMPSSQTPSAPTDAPPDKRPRLM |
Length | 222 |
Position | Head |
Organism | Hymenolepis nana (Dwarf tapeworm) (Rodentolepis nana) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Cestoda> Eucestoda> Cyclophyllidea> Hymenolepididae> Rodentolepis. |
Aromaticity | 0.10 |
Grand average of hydropathy | -0.478 |
Instability index | 53.77 |
Isoelectric point | 5.65 |
Molecular weight | 25394.49 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364143 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP05749 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 81.37| 23| 40| 93| 115| 1 --------------------------------------------------------------------------- 93- 115 (42.76/29.08) EVMPLAYYYVINGVVR.QCPDLGT 134- 157 (38.61/25.59) ELAPCARFHPSDGSYSwQNPEVET --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) PDKRPRLM 2) PYEILW | 215 11 | 222 16 |
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