<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05731

Description Uncharacterized protein
SequenceMSKFPSSDRSPIKGKNSGPPDVYPQKPNQLEDALTEHLVKDGYKYHRPVSDEYKLGRSFVEPSDLETAWDLFCNTLVVKDRLAPAYEPDHFHVPVRIPPVNDSIWKQISVWLSDLSGSNCNRRSTIFLTNKDRILSDLVTNRFPLSHALRLINRLIVYSTAPLENLKKKQKLDPTIEWTEEILRMLDKLFDGDLSNSFMNKYESMCKNWDYLFGLLTALYDNDLIEHWDVLKSLASKLEHMYQHALRYIPQDASLCSTDRPQPGRFDPFRSLKFVLPYFQRFCQRFTESELITRRVIYWACSVFSEQSRSCTLKSNASSTSIFCKPEDYAHFFLCSHHRPILLATSSLIIALTLECPSAAVWNKITPETGFRYLVGSPLDLLPCSLACLPITPGPEAANLRSCLLETETALLERSRLAEAGWCLFPSRAIASSECTDETNAEMFVRVLNELDLQDFNVCPEVDMITSLFRRFFPQELLDSPHSLTTLVTFLCKWAVSPTRTGLHRSIIVACLLDHLHSKVPHFTFQTCLLTFLDIHAPPSPNADLSGFRSLVCLFAELIDRGLFNHDVFVRTCIARGVFDSSFHPLANVNNPSLTASSVNALFSAPSLNNNFSVQSEISEDNDRFSVDNPDSVLSDLGGNPTSAVLPQRNSCDLNRHLQYLINFPLPQDDSYAHEQNQRAQLLYGSSARAHSRARELPRKISRDIVKLFTKSAHRLDVVHGELGKRKKKDRDPGSTPNGGTVGGGGQRGGASKESRSLDELLDGISSRFRSLNYYDMECVISKSIPAYLRSLNGSSTTSYIDTESSPSTREHIYFPALKSVFLFFELVENSLNIICLLETAVDTIDSLLVSSQSISYPCMASYLSQVWIRVIGILRAHQAVLMTMPNLQQRIFNCLIEQLRNKTPEKAQIKRCIIEYLRNLCHSSAYISRLAWPTLENQLQLSLSSGRLPSDKCKQLVCNALRNLMICDQDGSASFVESVLDYSAQCPELAMEWLPAIAAVVNPTAHGGGLSLSGISLTSPSLSQNSNSDFLSIGLIDDLTTWDNLTLLVGNLFASHCIDSDKLLDTLINPCLALGLDQSASPIDSLSETTVRVACHMLHRFFTLDTMKLTTFEACSPSLRIPESAILYSVIRRINYAPFIDTLKMLMILTNKGKSMELIEDAGEDGSVAGSDDNSSDNDRDSERETDDGHGDSSIDMTDGYDLTDGPTKNKRKRRRVYLGPAKNKRRKGPNSSQRVGSSVSLLNSRRRSRLASNLHPCTYAFLTTGQLPSDAEVKEMPLRDFAHLVLREICVTPWVREHFYRISAHLLQENVLIDKMISSNQTRFLLHIIYHPHDVKWFDLAACADNIADAILQLISGVNIWSLHSTRMELNLLCKQISFTSSKEALDQVANRIVNGFNEHALTYLKSASSASSFGEQLPEALPDIEVPESDNTWLLPSLVANLPNELKTHIVTKTCDILKGIKFFWRHKNAEDQERTVMLHSILLAHPVFSSILHVCMETVDPLDRLYEQLEYFVFGVKETRDRMPENLRTRHILQECLALRLSLLGICLSSANLSTDRLIGGALILAQLIGYGITEPHSNQTLFYACLDMLHTLLHNFAAQVGPDNQQYQNLAKKVRKKLAERHFTEGIEYIRPLLFIGRTGYPFVAVTPLAGTAGAGNRGDSVGVTSKPGSSSKLASFKSSGKSGGMNSSRVTNSQGGNGPISSSGPGGNNNGTPMSGGGGVKAFTRKRGYAFKSRDRFAPWEIYDVNRRPAFLAMCGAVQVPSAPSRYEDQANILLSHEHPINHRRSDDFYHTSLFPEVEVPVSLANQTVATPSPSNSSSSIDSASKQFSLGPVPPGKRHAGGGPDAGGPTLLAAPRRMQTQQNQQHPPPAGGRISKPEDMLYACQQQQQQMRMQAPSQQPPTKRKRNRAQLQQDEMQLFAQMYPPQTQSSSAMAAAQAPNSAAAVSVTTPQGKRKRIAGGGVVGVNSGQVASTMRRGYENGPLPATPSSQQTWSGGRVPPVSSGGGSGGRMLPNQRQNLSEFVQNRTKAQQQVAQAKAAQMAAAYAGGGGSGGGGGGGISNIEEHYSQPQASQSSQQTDSRYRSSGADPNYGFPEMLPPHGGNTGPFVPTSLPDFPSTVDPQIRLQRQQQQRYNQSQVVPDPPPYPGRANQQPQPNPQTKATAGPPPQMMQMQGQSAGQHRTPTYSQFMPSNEAAPRGVVSGPPPPPNFSRPLYDNSGSGEYH
Length2229
PositionKinase
OrganismHymenolepis nana (Dwarf tapeworm) (Rodentolepis nana)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Cestoda> Eucestoda> Cyclophyllidea> Hymenolepididae> Rodentolepis.
Aromaticity0.07
Grand average of hydropathy-0.357
Instability index57.15
Isoelectric point7.92
Molecular weight246475.30
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05731
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.05|      20|      22|    1850|    1871|       1
---------------------------------------------------------------------------
 1865- 1886 (22.72/11.19)	QTQQNQQ....hpPPAG.....G..RIskPEDM
 1889- 1912 (26.24/ 9.29)	ACQQQQQqmrmqaPSQQ.....PPT....KRKR
 2156- 2178 (22.09/ 6.57)	N.QQPQP.....nPQTKatagpPPQMM....QM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     306.38|      60|     259|    1675|    1735|       2
---------------------------------------------------------------------------
 1675- 1711 (46.05/19.73)	...................................................................................................SSSKLAS.FKSSGKSGGMN..SSRVTNSQGGN.GP.ISSSGP
 1712- 1735 (18.36/ 6.72)	GGNNNGTPmSGGGGVKAFTRKRGY.....................................................................................................................
 1811- 1841 (29.24/ 9.36)	........................afksrdrfapweiydvnrrpaflamcgavqvpsapsryedqanillshehpinhrrsddfyhtslfpevevpvslANQTVAT.PSPSNSSSSID..SA...SKQFSL.GP.VP...P
 1935- 1968 (31.04/10.48)	...................................................................................................SSSAMAA.AQAPNSAAAVS.....VTTPQGKR.KR.IAGGGV
 1969- 2011 (58.62/27.73)	VGVNSG...........................................................................................qvASTMRRG.YE.NGPLPATP..SSQQTWS.GGR.VP.PVSSGG
 2012- 2054 (47.74/21.03)	GSGGRMLP.NQRQNLSEFVQNRT...............................................................................................kaQQQVAQAKAAQ.MA.AAYAGG
 2055- 2119 (75.34/38.04)	GGSGGG....GGGGISNIEEHYSQ......................................................................pqasqSSQQTDSrYRSSGADPNYG..FPEMLPPHGGNtGPfVPTSLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.61|      16|      16|     895|     910|       3
---------------------------------------------------------------------------
  895-  910 (29.27/16.29)	CLIEQLRNKTPEKAQI
  913-  928 (31.35/17.94)	CIIEYLRNLCHSSAYI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     166.14|      44|     259|     532|     597|       4
---------------------------------------------------------------------------
  532-  577 (71.97/43.50)	FLDIHAPPSPNADLSgFRSL..VCLFAELIDRGLFNHdVFVRTC.IARG
  800-  832 (38.57/10.05)	YIDTESSPSTREHIY.FPALksVFLFFELVENSL...............
 1426- 1463 (55.61/25.36)	..DIEVPESDNTWL.....L..PSLVANLPNE.LKTH.IVTKTCdILKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.21|      19|     259|     738|     776|       5
---------------------------------------------------------------------------
  738-  756 (35.00/ 9.51)	NGGTVGGGGQRGGASKESR
 1003- 1021 (34.21/11.71)	NPTAHGGGLSLSGISLTSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.19|      18|      37|     466|     483|       7
---------------------------------------------------------------------------
  466-  483 (34.06/18.73)	TSLFRRFFPQELLDSPHS
  501-  518 (33.14/18.03)	TGLHRSIIVACLLDHLHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.57|      10|      37|    1075|    1110|       8
---------------------------------------------------------------------------
 1055- 1064 (18.99/26.12)	ASHCI......DSDKL
 1095- 1110 (13.59/ 7.24)	ACHMLhrfftlDTMKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.85|      12|      37|    1211|    1222|       9
---------------------------------------------------------------------------
 1211- 1222 (22.83/12.77)	NKRKRRRV..YLGP
 1245- 1258 (18.02/ 8.50)	NSRRRSRLasNLHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     129.63|      35|      37|     340|     374|      10
---------------------------------------------------------------------------
  313-  333 (25.51/12.57)	............LKSNASSTSIFCK..PEDYAHFF
  340-  374 (59.12/41.47)	PILLATSSLIIALTLECPSAAVWNKITPETGFRYL
  378-  407 (45.00/29.33)	PLDLLPCSLACLPITPGPEAANLRSCLLET.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.02|      14|      18|     202|     215|      11
---------------------------------------------------------------------------
  205-  222 (23.71/13.92)	MCKNWDYLFGLltalYDN
  224-  240 (19.31/ 9.92)	LIEHWDVLKSL.askLEH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.53|      24|      78|     681|     705|      12
---------------------------------------------------------------------------
  681-  704 (39.36/24.03)	QLLYGSSARAHSRARELPRKISRD
  707-  730 (39.17/19.26)	KLFTKSAHRLDVVHGELGKRKKKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.81|      21|      23|    1530|    1552|      27
---------------------------------------------------------------------------
 1530- 1550 (35.78/28.67)	NLRTRHILQECLAL.RLSLLGI
 1556- 1577 (31.04/15.58)	NLSTDRLIGGALILaQLIGYGI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05731 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GNRGDSVGVTSKPGSSSKLASFKSSGKSGGMNSSRVTNSQGGNGPISSSGPGGNNNGTPMSGGGG
2) IEDAGEDGSVAGSDDNSSDNDRDSERETDDGHGDSSIDMTDGYDLTDGPTKNKRKRRRVYLGPAKNKRRKGPNSSQRVGSSVS
3) MSKFPSSDRSPIKGKNSGPPDVYPQKPNQLE
4) PVSLANQTVATPSPSNSSSSIDSASKQFSLGPVPPGKRHAGGGPDAGGPTLLAAPRRMQTQQNQQHPPPAGGRISKPEDMLYACQQQQQQMRMQAPSQQPPTKRKRNRAQLQQDEMQLFAQMYPPQTQSSSAMAAAQAPNSAAAVSVTTPQGKRKRIAGGGVVGVNSGQVASTMRRGYENGPLPATPSSQQTWSGGRVPPVSSGGGSGGRMLPNQRQNLSEFVQNRTKAQQQVAQAKAAQMAAAYAGGGGSGGGGGGGISNIEEHYSQPQASQSSQQTDSRYRSSGADPNYGFPEMLPPHGGNTGPFVPTSLPDFPSTVDPQIRLQRQQQQRYNQSQVVPDPPPYPGRANQQPQPNPQTKATAGPPPQMMQMQGQSAGQHRTPTYSQFMPSNEAAPRGVVSGPPPPPNFSRPLYDNSGSGEYH
5) VHGELGKRKKKDRDPGSTPNGGTVGGGGQRGGASKE
1661
1160
1
1807
719
1725
1242
31
2229
754










Molecular Recognition Features






MoRF SequenceStartStop




1) FSRPLY
2215
2220