<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05728

Description Uncharacterized protein
SequenceMSASAVVGNRSRMIRLALVIDLACQKTYTDLMRLVDLLPSKTDLEKKIELARFFSRTRNLFIRLEALTKWANTSSKVDKCEKISNFLEVQSMLLLDTANVLNILHHNHLISARLPPFAMVLAIDIFVNKTYTRLPKAIERPFIPALRITEKDIRSSLVDLNRIIKFRLSISQLPRRFTNILIDKGRVVFTVPHEFKVTLTMLSESLNFPWRVLDIEFLVSDPKRSIEGSLVHPQQIHFLLTRVQSRILDRRFDKKPPLVHLYDMLHAFAMSLQLDVLFEQAKHLLSRRPTDPFNIEDYRPGQLLKVIYWRGLSTCNYEAVMGPDGKMRPSIYSITIHIDPVDSQRPLCVSHYPELNAEDAFKVGNYIQGSCLSIENLLTRAIVVRAECMLNEIRRDIIPLCPGPITLGEVPLSLCIPILWPCLPHEYLHLRVDSTQGLIRASFPASDQQKCTPLLKDLEVAFNRPTARRVTLDRSSSIECRAGNRGMRNLAADDKRWQVRLGEIFSHLRCLLGQWRIKWSSRGRIVKDCLPISIPIQKMGCYPPRHAGYLQVLERVKQEHSLLSYIKLFPNDEYYLLCEISPTVEGVLSVLYRYFLLKCTPLPTTVTDLRVAPEGRSLLHVSDDVVPDKDSQMVGVALQISHFFPLVGDSTDVLAGKLPSFSSLQFENKLNDLRRDVARTQCTASAKRMNRIRRLLDHLATTSEDEAAAAKRRRILLERFPSYAEASSQKPSGSLSNSVEMKETSQLEQIHMPDIFRLLASIEDDVVVNELNEQLSEQGIQHEGVVNDPLSGILTVDIKSISTIRLPIWAQSGAELLYHYANRVVLISSARSTSSMKQSSSASLAAFSSGASMRCWRLCISFKGLPANHDLLYQSPETPVNSLRDLTNFLHSVVTQWEGLCRLFTICAPVLDNSSCLPPGIAVQLFDAKSLILAYGPGLHYLVSLKFKKSFVELINLYTFTLSSY
Length965
PositionTail
OrganismHymenolepis diminuta (Rat tapeworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Cestoda> Eucestoda> Cyclophyllidea> Hymenolepididae> Hymenolepis.
Aromaticity0.08
Grand average of hydropathy-0.045
Instability index53.24
Isoelectric point9.03
Molecular weight109397.92
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05728
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     200.45|      62|     386|     501|     569|       1
---------------------------------------------------------------------------
  501-  569 (103.07/72.31)	LGEIFSHLRCLLGQWRikwsSRGRIVKDCLPIsipIQKMGCYPPRHA...........GY...LQVLERVKQEHSLLSYIKLF
  883-  958 (97.38/53.37)	LRDLTNFLHSVVTQWE....GLCRLFTICAPV...LDNSSCLPPGIAvqlfdakslilAYgpgLHYLVSLKFKKSFVELINLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.88|      31|     102|      18|      48|       2
---------------------------------------------------------------------------
   18-   48 (52.79/31.58)	LVIDLACQKTYTDLMRLVD..LLPSKTDLEKKI
  121-  153 (48.08/28.19)	LAIDIFVNKTYTRLPKAIErpFIPALRITEKDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     193.27|      66|     387|     199|     275|       3
---------------------------------------------------------------------------
  154-  252 (84.95/62.73)	RSSLVDLnriikfrlSIsQLPrrftnilidkgrvvftvphefkvtLTMLSESLNF.....P.WRVLDIEFLVSDPKRSI.....EGSLVHPQQIHFLL..TRV............QSRILDRRF
  575-  611 (34.13/13.16)	.....................................................................YLLCEISPTV.....EGVLSVLYR.YFLLkcTPL............PTTVTDLRV
  630-  720 (74.20/47.44)	DSQMVGV........AL.QIS......................hfFPLVGDSTDVlagklPsFSSLQFENKLNDLRRDVartqcTASAKRMNRIRRLL..DHLattsedeaaaakRRRILLERF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     218.30|      55|     488|     259|     314|       6
---------------------------------------------------------------------------
  259-  314 (88.39/63.58)	VHLYDMLHAFAMSLQLDVLFEQAKHLLSRRPTDPFN.IEDYRPGQLLKViYWRGLST
  750-  803 (76.75/50.24)	IHMPDIFRLLA.SIEDDVVVNELNEQLSEQGIQHEGvVNDPLSG.ILTV.DIKSIST
  815-  857 (53.16/32.44)	....ELLYHYANRV...VLISSARSTSSMKQSSSAS.LAAFSSGASMR..CWR....
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05728 with Med14 domain of Kingdom Metazoa
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