<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05694

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMPYSLRSFFFQTELNGLKWKCLTTPLSQRTWTSLEQDPVLSAYARCLQAGILCAWRRQPPQPSGTLAAMQLPDYRIDVVKELWVFWYSHEEPDCLTEYTSHLACTEDGQGNWSVPGIQYETRTLFFKALHNLIERNMLKNGYIRIGKYFTRPYEVPSSDRIRCSPNYVNGISFNFFVHGENIVCATVSVQRQPTLFRLSRRHLDLGKKQPVILGPWSMRAVLLPEQPRIVDSVTPILQQQLPTSQCGSFTSSSATYSSSYREPSSSVAHQINPVASSSIDDTCNSSHDGVGTISKAAVDKLWSEWLQFFCLIVNVERNLSSADTVGYIGYTENTSQAKSSLPKMVLVDVDGVHMWYPSSLIVVQASDDLLMRQSEKTVNDDDSDFFNSGSSSSSFTARTPPATGGHSRLRSTPSFRKRKKRLSECDVGSNAERHNAMYGAMVNGARAAQRFFEESFIAPANNRRKENTESPSSSGLGLLMSAATSDDDCRWNFTDGMRRKDREEGCGCHQCRCARQQSSGTAAIPNISSQCLTSQQGMYACISQEPSQSCCTPINLQSNGSSLEARKERSAIFHRRPSSCTRSPSPPRSPPWEKKILATSSETVDSEHNLDWIRESYFRNSRSSSRSGRIDPLHEDRHICPKTPDASAITESPERRRVQKNSVQMFGKIGSCKPIYQNLSPTSRPRSPACDTSQTESLNRMQSKDYSSSDFTSLSTRKHGHPIMEQQPNLINSMRLKKGKTSKGRKRKAHEKLEWSGIESLDVSFLTSKVGEDGEDGDDINFTCSDEFKLRECKLKVKDESVESSSSRSAVPQIESSLTSISTQAQDGVRSLPVFSQIGSVLPSSTGVNLTPSIFTSDCDTQPLYLDDCNPSTIAMIERRSPVDTVVTDSVHLSPPASNERVEPTQILGGTVANVMARVGGPPSVGDYMIYPTPPSVDATQSQQFSPQNTLIQTNPTSILYPPTVSYMAAAAATAVNLCHNIPPTQLPPSIISETDITTEAVSTVRRELDSDDERLLGKLHYSINENPVYGKFMKLEMALSGKFAGNILAKEFLSLEGKDCRVLEGVYADQLKLIKTAVAAREKRRKVGRAPDYLFMRERFRNLAPHSSFTSVRHYRMPCNNGHMLSSHCLPTLQMIPHTISMSGVPSFVTSGPSFAGTSYNGNNSMMSLMMGNGCMPSGGTGIVQPMPGSSRMGVVHMNQQMSMAHLRPLTRFVSGCKKLIAEAVQFQMMFRCNMSGNLPAPHAVHSSDSYGIDSQSQASGEPPQPFSQAINHQYSAVHNVQAGSMMYAQSPHIMRPNTLMAQAQNPNLMCGPRTSQNSIMAVPPSIGSPNNGGLFGNRLMNMPPVMDTAAVPSSNMSNSTRTHPEGKSLVLAVLLQDTVLDLHYDSVFDACPICSCNGSIRAKELGVYITPPEVLRQPPAQQQLIVSKPTSGFYNSTSNSCNCGFSAVRHRYLSMKAGLFAEDAKEATDINETQNQPAIPHTIWFDSMSGRDMNFIALLREQTLVRDLGGLLDHVTLLSLQCERASQTERIGSDSTKHCEYIISEVDQRELPLVFQAACEVACMEMNCRRPPHDVRSVLLHDWGVQVSNEMREPRESECMALLQEIGPILEESLRIARSSPLFGSNNIVEGPLTWRFFDRKALKAAGGMEDDSGPEAVPNIVVASEKDAVITSPQIIRLWEKMSLEPYDQPKDVLYIGVVPDNLICIEKTKKYLMDLSRMYEQCRFGRHIPFSREVLRDGLLRVPTRYPATNPGECDNFLNQVERHIGDNKSLITRLKVYMQYFENEMARILINNDDIFSRDKYRAALAENQMHSVPHVSMASHQCGGYGASSSDHMPPPSAPGSIIISGQSSEASQGPSSASGPSSAGATSSTIGESLTPDCSIGDGGAQNLTGFPSFMAEQLIADGVIAEDEPGTLPHVIVIYLVNPFLLGAEENPLVARVVTVALMRAFNALLYRLNNKRRPQLQLEMIALQSIFDYCGVSADFLKDERGRLNGYDQGRLEKSQNERLSSSDSLKTVAFSVYTHSRVVLPDIVRGILPKSMTRFGPASAMVDLLNELERKEPIYYKIPSKPFILAPPSPVMQRPNCDLMQINTDEAVLFVSYCLIGNDWLAATVTDHQGHSLDNCLINLRLKPDHKRVNMRYKQSTQIRDSLYRLWSYILGTLANGTRNWRLVIGRVGRIGHGEFKFWTQILSKSYLKQVGTRMKHVCRACHLMPGTSEVPGVLSACLVSLEPEAHLRVFPSSFQHDDRFLKNSRHRTLITPDDTSCTHILVFPTSPELNLDHQGGNGVAELEEDDFSNLLTEEIGEEFSELIGNGEDLMTNGTGPPPQSASFRLGGNTGIPSEYADVSIENQPLATGYYISTAPASDLPEWFWSACPSAKRRNPVHLKSSLHLNTPNVQQGDDISSFGKSTEACHHQLDSQATADVLRYVLEMYNALSWLNMDLVSGERRSCLPVHIQALMWLCNAVNRFIN
Length2478
PositionMiddle
OrganismElaeophora elaphi
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Elaeophora.
Aromaticity0.07
Grand average of hydropathy-0.381
Instability index58.70
Isoelectric point6.61
Molecular weight274487.79
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05694
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     180.06|      49|      51|     888|     936|       1
---------------------------------------------------------------------------
  888-  929 (64.40/35.28)	..........TDSVHL...SPPA..SNERVEPTQILGGTVANVMARVGGPPSVGDYM
  930-  981 (84.25/48.74)	IYPTPPSvdaTQSQQF...SPQN..TLIQTNPTSILYPPTVSYMAAAAATAVNLCHN
 1409- 1441 (31.41/12.92)	VYITPPE.........vlrQPPAqqQLIVSKPTSGFYNSTSN...............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     385.67|     154|     485|      38|     200|       2
---------------------------------------------------------------------------
   38-  147 (164.69/105.80)	..............................................................................................................................................................................................................................................................................................................................................................................................PVLSayARCL..QAGILCAWRR..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QPPQPSGTLAAMQLPDYRIDVVKE.LWVFWYS.H.EEPDCLTEYTS..HLACTEDGQGNWSVPGIQYETRTLFFKALHNLIERNMLKNGY..IRIGK
  148-  200 (22.84/24.80)	YFTR...PyEVPSSDRIRCSPN..YVNGISFNFFvhGENIVCATVSVQRQPTlfrlSR.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  525-  629 (139.78/83.00)	..........................................................rhldlgkkqpvilgpwsmravllpeqprivdsvtpilqqqlptsqcgsftsssatysssyrepsssvahqinpvasssiddtcnsshdgvgtiskaavdklwsewlqffclivnvernlssadtvgyigytentsqaksslpkmvlvdvdgvhmwypsslivvqasddllmrqsektvndddsdffnsgsssssftartppatgghsrlrstpsfrkrkkrlsecdvgsnaerhnamygamvngaraaqrffeesfiapannrrkentespsssglgllmsaatsdddcrwnftdgmrrkdreegcgchqcrcarqqssgtaaiPNIS..SQCLtsQQGMYACISQ..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EPSQSCCTPINLQSNGSSLEARKErSAIF....H.RRPSSCTRSPS.......PPRSPPWEKKILATSSETVDSEHNLDWIRESYFRNSRssSRSGR
  634-  684 (26.04/ 7.62)	HEDRhicP.KTPDASAITESPErrRVQKNSVQMF..GKIGSCKPIYQNLSPT....SR.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1263- 1319 (32.31/ 9.96)	....................................................................................................................................................................................................................................................................................................................................................................................................................prspacdtsqteslnrmqskdysssdftslstrkhghpimeqqpnlinsmrlkkgktskgrkrkaheklewsgiesldvsfltskvgedgedgddinftcsdefklrecklkvkdesvessssrsavpqiessltsistqaqdgvrslpvfsqigsvlpsstgvnltpsiftsdcdtqplylddcnpstiamierrspvdtvvtdsvhlsppasnerveptqilggtvanvmarvggppsvgdymiyptppsvdatqsqqfspqntliqtnptsilypptvsymaaaaatavnlchnipptqlppsiisetditteavstvrreldsdderllgklhysinenpvygkfmklemalsgkfagnilakeflslegkdcrvlegvyadqlkliktavaarekrrkvgrapdylfmrerfrnlaphssftsvrhyrmpcnnghmlsshclptlqmiphtismsgvpsfvtsgpsfagtsyngnnsmmslmmgngcmpsggtgivqpmpgssrmgvvhmnqqmsmahlrpltrfvsgckkliaeavqfqmmfrcnmsgnlpaphavhssdsygidsqsqasgEPPQPFSQAINHQYSAVH.NVQAG.SMMYAQSpHiMRPNTLMAQAQnpNLMCGPRTSQN......................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     185.13|      47|     479|    1324|    1370|       3
---------------------------------------------------------------------------
  814-  845 (35.26/ 9.96)	IESSLTSISTQAQDGVR..SLPVFSQIGSVlPSS..............
 1324- 1370 (81.75/31.36)	VPPSIGSPNNGGLFGNRLMNMPPVMDTAAV.PSSNMSNSTRTHPEGKS
 1822- 1865 (68.13/25.08)	...SMASHQCGGYGASSSDHMPPPSAPGSI.IISGQSSEASQGPSSAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     208.21|      66|     740|    1158|    1226|       8
---------------------------------------------------------------------------
 1158- 1226 (119.02/87.57)	GTSYNGNNSMmslMMGNGCMP..SGGTGIVQPMPG.SSRM.......GVVHMNQQMSMAH...LRPLTRFVSGCKK..LIAEAV
 1866- 1946 (89.19/57.33)	GPSSAGATSS...TIGESLTPdcSIGDGGAQNLTGfPSFMaeqliadGVIAEDEPGTLPHvivIYLVNPFLLGAEEnpLVARVV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.58|      27|     689|     757|     783|       9
---------------------------------------------------------------------------
  757-  783 (46.80/35.37)	GIESLDVSFLTSKVG...EDGEDGDDINFT
 1446- 1475 (41.78/30.64)	GFSAVRHRYLSMKAGlfaEDAKEATDINET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.57|      23|     740|    1093|    1115|      10
---------------------------------------------------------------------------
 1093- 1115 (42.24/29.39)	DYLFMRERFRNLAPHSSFTSVRH
 1798- 1820 (41.33/28.57)	DDIFSRDKYRAALAENQMHSVPH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.71|      26|     740|    1014|    1039|      11
---------------------------------------------------------------------------
 1014- 1039 (46.38/32.87)	ERLLGKLHYSINENPVYGKFMKLEMA
 1766- 1791 (46.33/32.82)	ERHIGDNKSLITRLKVYMQYFENEMA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.93|      23|      95|    1502|    1528|      12
---------------------------------------------------------------------------
 1502- 1528 (34.75/35.60)	RE...QTLVRDLGGLLDHvtllSLQCERAS
 1597- 1622 (33.18/22.79)	REsecMALLQEIGPILEE....SLRIARSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.28|      40|     205|     248|     289|      15
---------------------------------------------------------------------------
  248-  289 (66.78/52.39)	SFTSSSATYSSSYRE.PSSSVAHQINPVASSsiDDTCN.SSHDG
  455-  496 (62.50/42.16)	SFIAPANNRRKENTEsPSSSGLGLLMSAATS..DDDCRwNFTDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.41|      22|     689|     863|     884|      20
---------------------------------------------------------------------------
  863-  884 (41.54/30.16)	PL.YLDDCNPSTIAMIERRSPVD
 1554- 1576 (40.87/29.52)	PLvFQAACEVACMEMNCRRPPHD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05694 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AVHSSDSYGIDSQSQASGEPPQPFSQAINHQ
2) GGYGASSSDHMPPPSAPGSIIISGQSSEASQGPSSASGPSSAGATSSTIGESLTP
3) PIYQNLSPTSRPRSPACDTSQTESLNRMQSKDYSSSDFTSLSTRKHGHPIMEQQPNLINSMRLKKGKTSKGRKRKAHE
4) SSSRSGRIDPLHEDRHICPKTPDASAITESPERRRVQKNSVQMFG
5) TVVTDSVHLSPPASNERVEPTQILGGTVAN
1245
1829
674
623
885
1275
1883
751
667
914










Molecular Recognition Features






MoRF SequenceStartStop




NANANA