Description | Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MDDEEYMKPMLPTVPEKCGPPVIPLGHLIEFAVQQIFHELTVLSELLPKKLDSDRKISIVQFAHSTRVLFIKLLAVVKWVKSSKKFESCASICYFLDQQSQYFVDTADRLVQLAREELVFARLPIFQVALAVDVLTVGTFPRLPLCIKSRFIPDPPITSREEACVLARLNQVIQYRLSSYGTKLSPRISKTVIRNGMVTMTVNGEFEVSLTLLGERPATKWTLLNIKILVEDYEIGFGTKLVHPLQVNMLHNVLQLRMDKSLEPLEEVYNLLHSFAQMLQLDVLFCQATQVFSGDMCQYAAIERYDRNMGILTLAYWLKRTHNRYTSQYKIKIFIDKENQHNGLRVRHFPVGKGLPYIDDRSGRLSINRLLSETVGVRCRERLLRIRERLGLLKPPVIVSLTGRAAPTLTYPLLGAQSHADEMLVVSVNDFSGNVIAVVRALGSCTELRELEQLIDDRVPLQTITDKMERLRILLMLERYRKAVAPLPVRIVPENVFCARLSSLPELPPDRICLQFIKEEMYYLIVSFTPNGQIGVNIDMYLLSNVERKLNMVRLHPSQLLTTLPESSFLSGKSDDDLEPPTKRRRWLGDKRLLTSAVAT |
Length | 600 |
Position | Tail |
Organism | Brugia timori |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Brugia. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.012 |
Instability index | 39.90 |
Isoelectric point | 9.01 |
Molecular weight | 68561.59 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082 |
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP05679 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 263.07| 88| 96| 358| 452| 1 --------------------------------------------------------------------------- 358- 452 (132.87/97.75) IDDRSGRLSINRLLSetvgvRCRERLLRIRERLGLLKPPV.IVS...LTGR..AAPTLTYPLLGAQSHADEM..LVVSVNDfSGNV.IAVVRALGSCTElRELE 455- 551 (130.19/78.15) IDDRVPLQTITDKME.....RLRILLMLERYRKAVAPLPVrIVPenvFCARlsSLPELPPDRICLQFIKEEMyyLIVSFTP.NGQIgVNIDMYLLSNVE.RKLN --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 96.10| 29| 236| 73| 101| 2 --------------------------------------------------------------------------- 73- 101 (50.32/35.29) LLAVVKWVKSS.KKFESCASICYFLDQQSQ 311- 340 (45.78/31.51) ILTLAYWLKRThNRYTSQYKIKIFIDKENQ --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) KRLLTSAVAT 2) KRRRWLG | 591 583 | 600 589 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab