<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05647

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMAMNGGSLEDCYSNVYALTELNGLKWRCFLTPSNSPRGIPIQSDPILKAYGKCLRDGLLCTWRRKPLQMSTQPEPLPLPSFTNEILLIDECLLGSAANGINYEVRVLFFQALHTMIERSMAHDGFVRFGRWFTRPLREPLFGLQRLLPRYFFVHGGNTVCMTVNAQRQPPLLRLCRRYIVDFDTILDLHFDSVFDACPICSCNTSIRARELGLYITPPDVLRMPAHLQQAQIGSWSGFALEQANVCTCGFSAVRHRYLSLCSGLFPEDSREATAIEHSVAPVNGLGAEVGLQASSQIWLAQEVSFDASSNSEYVLSQVDATELIALSILTPGNRSRNTNQPILQFFHPWGLQVINPREAEWRGLLCDIGPILERALQPKACTPIHDDDISSPEPIPYINVAAEKDAIRAAPHVVRHWEHLSLGPIDQPKDVLYLAVVPDIYGVIVHLRCKILYLRMYERMRFGRHIAWPTGVDGRDGCVRVGCRTQSGKYPTETTTLDFLNLVEFFMNFQHCSQFALQLFTQQMEENVLQLVTERDDLFERATFRETLALDWRAKRASVAAVALAVEQRLAEIYKFTLPKLLTLDAAEQGGSVVAPEPLPTEPPLEPEDVPVDDPGTLPHVVVIYVFNPFTWGTEFRSGLFTRVATLAVMRAFNTVCLRLPSYRRSQLQLEIIPMEQVTDLLGCLPDYTNESGTSQSLLENIRFNLFCCIIQATVLSVYSQPRVLTADCIRSVQARCMTRFGPGSSLLDSLDEWERSGTNVPSNPYHLAPPPLLYQKYENGRVLQSSDEQVLYVTYCVAGSDWLCVTVTDSLGRLNDNCLINLRTRHDHHIYKYRQQTQILDAMGRLWTYILGILSMETRNWRLVIGRLGRIGHGEFRAWTYLLNKTALKRHSARLKEVCTACAQMPGCTGTPSILSACLVSTEPEPYLRVFPGFTFMDEMNCLSKKARSAAPDDTSITHIMVFPTSADIQLGSTDQHAVGEDDWDFSDMDIPQDGNDLGDDFLSSSNFRAAGNSFFSENTADVSMENQPLATGFYVSTAPAADVPDWFWASCPSAKNRTPVHLKSSLHINVPLVHQGDEFLQGKAAAGDKQEKESAHPLDSTRTDEVLRHVLETYNALSWLNIDVVSGERRSCLPVHMQALNRLYHSVARLIM
Length1154
PositionMiddle
OrganismAngiostrongylus costaricensis (Nematode worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Strongylida> Metastrongyloidea> Angiostrongylidae> Angiostrongylus.
Aromaticity0.09
Grand average of hydropathy-0.131
Instability index48.63
Isoelectric point5.74
Molecular weight129585.60
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05647
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.90|      18|     202|     378|     414|       1
---------------------------------------------------------------------------
   36-   54 (29.22/23.40)	PRGIP.....IQSDPIlKAYGKCL
  392-  414 (27.68/17.91)	PEPIPyinvaAEKDAI.RAAPHVV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     210.78|      57|     494|     131|     188|       2
---------------------------------------------------------------------------
  131-  188 (101.36/75.05)	WFTRpLREPLFGLQRLLPRYFFVHGGNTVCMTVNA.....QRQPPLLRL.CRRYIVDFDTILDL
  632-  681 (84.52/56.68)	WGTE.FRSGLFTRVATLA...VMRAFNTVCLRLPS.....YRRSQL.....QLEIIPMEQVTDL
  696-  731 (24.90/10.50)	.............QSLLENIRF....NLFCCIIQAtvlsvYSQPRVLTAdCIR...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     282.62|      89|     493|     421|     625|       4
---------------------------------------------------------------------------
  446-  545 (152.15/209.02)	HLRCKILYLRMYERMRF....GRHIAWPT.GVDGRD.GCVRV.........GC....RTQSG....KYPTETTTLDflnlveffmNFQHCSQFALQLFTqqMEENVLQLVTERDDLFERATFR
  767-  878 (130.47/49.00)	HLAPPPLLYQKYENGRVlqssDEQVLYVTyCVAGSDwLCVTVtdslgrlndNClinlRTRHDhhiyKYRQQTQILD.........AMGRLWTYILGILS..METRNWRLVIGRLGRIGHGEFR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.75|      13|      75|    1000|    1014|       6
---------------------------------------------------------------------------
 1000- 1014 (19.29/21.24)	GDDFLSSSNfrAAGN
 1078- 1090 (23.46/16.80)	GDEFLQGKA..AAGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.36|      18|     521|      73|      90|       7
---------------------------------------------------------------------------
   73-   90 (33.68/20.53)	PEPLPL.PSFTNEILLIDE
  596-  614 (30.69/17.91)	PEPLPTePPLEPEDVPVDD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05647 with Med13 domain of Kingdom Metazoa
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