<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05634

Description "Uncharacterized protein, isoform B"
SequenceMLSMLQEKRPLKRTRLGPPDIYPQDAKQREDELTPTNVKHGFTTTPPLSDEFGTAHSSNVNASRVSAFFSGVLAKKEELMTLPDTGRKKQQINCKDNFWPVSPRRKCIVDAWFKDLAGNKPLLSLAKRAPSFNKKEEIFITLCENQVNMQRATWFIKLSAAYTLSFTESKNKKRSIYDPAAEWTGNMIKFMKELLPKLQEYYQQTHDKASSNGSHSAGLTTASSGNSNGISVNSSGGNAAPPSATANVIPVPSMSSPLPPIHSPANGQPSTAGGVVGSGSVIPPAGALGGGVSSGPGGPGGCSANSSTAVGAPVPPGSSISGIGSQFEDSRNALKYWKYCHQLSKYMYEESLLDRQEFLNWILDLLDKMRTQASFDEPLKKLVLSFALQYMHDFVQSERLCRKMAYIVSKKLAQLLNAAVEQQGIKDVDGGVGAGAGGGENKLQHDPFELALQEQMSCPHHRDIVLYLSTILQIITIECPTALVWSGIAAHRAPSSLVGSPLDHLPLAPSVLPMPTRCPRTNTEIRRQLRAAESEIVLRTQHAEQRWFASKWLSAGKNHYTKVLATLDHLDTHCFDRMEQCNSIDTLYVHIFPRRRDEDQQDPQQQQQPRPVYEPKQDKDTVRILCEWAVSSQRWGEHRAMVVANLLDKRQIDVTSTPSEQSSDKEDKDSLASGAGLIDGLPVFQHVLMHFLDHDAPVLDDHLSSAQQRTEFTNLVQLFSALIRHDVFSHNAYMHTLISRGDLLSLESVLASKASTTATKSSPAAAATQATTTHGFDDDPFGGGIDFKHNEFDDSNVDDDLDKLVQNIKEKGQHDAPDSPKIGPPGDGEPSTGGAGGSISRHYVYTKHFPIPQDESSYSSESNQRYILLFGVGKERDEKKHAVKKMSKEIGKLFTKKFSIDVAEGGKVKKHSRNEFNFEATTAKCQQMAYFDQHVVTAQCAANVLEQLNGFALGNNNYLPVQEHVAFLFDLMELALNIYSLLELCDNLLKELPEVEHQLQLKKSNMVRGYTTSLALYIVSILRRYHSCLLLSPEQTLSVFEGVCRTIRHVNNPSECSSAERCILAYLSDLHESCVLLQGKEQSTEYYQQLQCIKRFKDIFNTPEQLSLPPQGYNPQLLQELFVAPRRGGKLEPHWLRQLHESSANVYSFVSNAVIAVCRETDNERLNDVALACAELTASCNVLSEEWIAALQSLCSGSKSPRYPHLGGQVDIGQGKTHNALAVFVCILVARHCFSLADFVSKFALPTLARSVSAGGGEMSVDAEAGARLTCHLVLKLFKTLEIPQPGMYSVSTSPNPLHAVGSDFSIRLSCDRHLLVGAHKTIPIAAVLAVLKAILIVVDNAALKTSMAGGTGSSSSGGVGGAFGSGKRSGFNTPVHPGSTPKSNEQRPADLSQILGTSDLQLGNSLTSEQEALQQPSVGGLEQISLLEFAQAVLKQICAQEHVLERCLKNAEGLCDMIIDEMLTAKQAQRVLHMICYPEAEFNIISELDQRAMIVRILENLGQWTLRISWLDLQLMYRQSMGNNAELNVWLDTVARAAIDVFHMEEIILPGSLKATHKPKPSTWLVAPLIAKLTPAVQGRILRVAGQVLESMNYFSKVSKSDCNSSGSGDEREKSNSCHSSNSYGIGGVAARNKKMPLNYQPFLGLILTCLKGQDEYKENLLVSLYSQLSQCLQSFAELDTIGGTDEPQAREEILDALQLRFSLVGGMFEAIQKNSTPTTDWAILLAQLVCQGVVDLSCNRELFTTVVDMLATLVHSTLVSDSQSERDENKKLYLNLMKKLKKEIGEKNNASIRVIRQLLPLYKQPTEVIACEHAGMDTKGNKICDMEKKQLRISDKQRISVWDILEGHKNPAPLSWVWFGAVKLERKPLTYEEAHRNLKYHTHSLVKPSSYYYEPLPLPPEDIEPVPEKICIKDEMMKADTPSSVDQSPSAVVGTGRGRGKGTTTRKRKPKNPKTPPVVNTQQQQPQLAPQPQQPPNVQQQQQQMQQQQQHMQQQQMQPNQMGMQMNMPQFAPNPNMMQQSALMQQQQQMQQMGTNQLQQQLNVGGGNGQQNPQMNFMQQGPGGGAAGPQGLPGQQQQQQWHNAPQQQQPPQQYHNHYAPHQQNMQSNRIERPPQNANSKQALSQMLRQRQPFQQQQQQQPGGGFNPMQQQQPQAQQQPGPQQQQMNPNQMRQQQMTAQQNPQSVAAFNAMQQQQQQNAQQQQQQMNPNQQQQQFMRGGNMRPGMAPNQMNQMNMGGQGIPQNSMMQQQMTQGMVGMVNPNANQMMQTGGAQGGNGVGVGVGVGVGVGVTTGANPNMGMGGMPQQGMMQQQAQQQPQQQVQFQNFQNQYQQQQQQQQQQGMQQQGGGVGVGVGVGMAPNQQQQQQANMMGNFNPQMQQANRNNPDFMAAAAAQQQQQQQQQRGVPGGMMAGNRGQYINQAPNVTMSNMMGPGPGGVGVGVGVGVGQVPPYARQQPAGGGKPGVLSTQQQFQQQQQQQQLRHQQMMQMQGMGGGGGGGMGAGPQQASGAGVGGGGGGMVQQQQSMNQQQTPNLVAQLQRQNMMGQQQQYQHQPPPY
Length2557
PositionKinase
OrganismDrosophila pseudoobscura pseudoobscura (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.06
Grand average of hydropathy-0.541
Instability index54.71
Isoelectric point7.94
Molecular weight281414.46
Publications
PubMed=15632085
PubMed=17994087
PubMed=23185243

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05634
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     141.02|      16|      18|    2491|    2506|       1
---------------------------------------------------------------------------
 2074- 2089 (25.52/ 6.44)	LPGQQQQQQW.....HNAPQQ
 2200- 2214 (28.38/ 8.17)	NAQQQ.QQQM.....NPNQQQ
 2300- 2320 (27.10/ 7.39)	GMGGMPQQGMmqqqaQQQPQQ
 2334- 2346 (27.92/ 7.89)	QQQQQQQQGM........QQQ
 2491- 2506 (32.11/10.43)	GMGGGGGGGM.....GAGPQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     199.75|      19|      64|    2280|    2298|       2
---------------------------------------------------------------------------
 1971- 1992 (29.07/ 7.27)	APQPQQ.PpnvQ.QQQQQ..MQQQQQ
 1994- 2009 (28.71/ 7.07)	MQQQQM........QPNQ..MGMQMN
 2046- 2065 (27.36/ 6.36)	VGGGN......GqQNPQMnfMQQGPG
 2145- 2162 (31.27/ 8.44)	GGFNPM.Q...Q.QQPQA...QQQPG
 2218- 2236 (27.89/ 6.64)	MRGGNMrP...G.MAPNQ..MNQ.MN
 2237- 2253 (26.70/ 6.00)	MG.GQG.I.....PQNSM..MQQQMT
 2514- 2531 (28.76/ 7.10)	GGGGGM.V...Q.QQ.QS..MNQQQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     167.72|      32|      76|    2372|    2403|       3
---------------------------------------------------------------------------
 2016- 2045 (39.23/10.61)	.NPNMMQQSALMQQQQQMQQ........mGT.N..................QLQQQL.N.
 2124- 2169 (35.35/ 8.81)	ALSQMLR..QRQPFQQQQQQ..........QPGggfnpmqqqqpqaqqqpgPQQQQM.N.
 2351- 2383 (48.17/14.75)	GVG..VGVGMAPNQQQQQQA......nmmGNFN..................PQMQQA.NR
 2384- 2425 (44.96/13.26)	NNPDFMAAAAAQQQQQQQQQrgvpggmmaGNRG..................QYINQApNV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.33|      19|     156|    2266|    2288|       4
---------------------------------------------------------------------------
 2266- 2288 (31.64/25.30)	QMMqtGGAQGGngVGVGVGVGVG
 2429- 2447 (41.69/20.60)	NMM..GPGPGG..VGVGVGVGVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     113.48|      25|     278|    2175|    2199|       5
---------------------------------------------------------------------------
 2175- 2199 (44.34/17.79)	QQQMTAQQNPQSVAAFNAMQQQQQQ
 2454- 2478 (44.66/17.98)	RQQPAGGGKPGVLSTQQQFQQQQQQ
 2540- 2553 (24.49/ 6.16)	RQNMMGQQ........QQYQHQ...
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05634 with Med12 domain of Kingdom Metazoa
Unable to open file!