<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05552
Description |
Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MMNNYGNIMMDSPRSSPHGGRSPVVARQDSSGTLKTTISLGKTPTIIHTGPFYSMKEPPAKAELTGDKDLMTEYGLHHTLTKFKEKKFKESLASFLPNIPGINDLITHPVENSTLRSVIEKPPIGGKELLPLTPVQLAGFRLHPGPLPEQYRTTYATPARKHKNKHKKHKHKDGITTGGPESTLLESFSDSAGLETYEKKHKKQKRHEDDKERKKRKKEKKRKKKNQSPEPGGALGIGMPSGGGGGAAPAGMGGPVMGATAIMSNPMSSSGVGMGVGVGMNAGMGANSFSSSLQMQQQLSMQHQQQQQQMPSGALMGSVLSSGGNGPGGNAGNAGGGPGSLLMSQF |
Length | 346 |
Position | Head |
Organism | Drosophila mojavensis (Fruit fly) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota>
Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea>
Drosophilidae> Drosophila.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.720 |
Instability index | 61.13 |
Isoelectric point | 9.91 |
Molecular weight | 36685.49 |
Publications | PubMed=17994087
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
transcription factor binding GO:0008134 IEA:EnsemblMetazoa
|
GO - Biological Process | positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblMetazoa
|
Interaction
Repeat regions
Repeats |
>MDP05552
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 118.07| 32| 52| 257| 289| 1
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257- 289 (57.43/23.17) MGATAIMSNPMSSSGVGMGVGVGmNAGMGANSF
310- 341 (60.64/21.70) MPSGALMGSVLSSGGNGPGGNAG.NAGGGPGSL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 166.03| 51| 52| 128| 179| 2
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128- 173 (68.48/36.96) .......ELLPLTPV.QLAGFRLHPGPLPEQYRTTyATPARKHKNKHKKHKHKD
174- 226 (72.57/35.28) GITTGGpESTLLESFsDSAGLETYEKKHKKQKRHE.DDKERKKRKKEKKRKKKN
228- 249 (24.98/ 7.42) SPEPGG.ALGIGMPS.GGGG.....GAAP.........................
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 92.69| 30| 33| 40| 72| 3
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40- 72 (47.63/34.49) LGKTPTIIHTGPFysmKEPPAK..AELTGDKDLMT
76- 107 (45.06/24.63) LHHTLTKFKEKKF...KESLASflPNIPGINDLIT
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