<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05548

Description "Uncharacterized protein, isoform B"
SequenceMMADHLDEPPQKRVKMDQTDLYFLEDNLPDELVSSSSGWSDQLNTGGGGGGGVGGVVSTASGVVGAGGPNKPPTQGPGPGVVPPQMNGAGGGGDDGSGNGGSGAAGSQLRQLQHHQHLQQLLQHQQQGNKGAGGGMVVPGMNQLGSKSPNLQSPNTAGMQVATQMGMVNSMPMSISNNGNNGMNSIPGMNSIAQGNLGNMVLTNSGGMGTIGGAGLVNTLKQPGGASMMSTVPGSVGVSSVTGAAPSQGMHMQNGPMMGRMVGGQQHLLRGPHLMGGGAGGGNGPGGVVGAGGGPRMQNPNMQLGQINNMPYGVGNYGAPGSNNTQLLAQQMAQRGAGGVGGVVAPNMSAGMAQANRPIGTVVPMSNLGGDGAPPGAGGLVGNTQQQQQQLAAANAQMNSQQQQQQQPPGVQQGAMGPRAPQPNQLLGHSQQQQQQQQPGTSQQQQAIASGVASSVSVAAPAPASSNMTDERKKQIQQQLMLLLHAHKCNKRENMNPNREVCSVNYCKAMKAVLAHMATCKQSKDCPMQHCTSSRQILLHYKTCQRSDCIICSPFRQNNSLFQNASGGGGGGGAAVAPNASPLQQQQQQQQQQQQQQLPQGQQQVPQNPSGVGVGVGGGVGVGVGVGVDTKQVAQSAGTCGAPNTAIVLPQQQAAGASNVPKGNTDMGQQQQQQQHQQVQQQELRRFEGVGSIGQVGPVPAGMLGAPGQGMAPGIRMQGAPSVRVLGVQPGQPGSTMASGGVPVPVPVPGQNVLPGANDVGSLQQQQQQAAQAAQQSGQLMLQGCNTGTGGRRRALQNMVDQQQQPNAQQQSVQQQQQQQLGNIPAPLSVNVGFNNANFVGVGDKQQQQQQQQQQQQQLVGQSDQMTKLKLQAQAQAQVQAHVNVVSAGGAPGSGNSASGGASVLMPADTTGGANSASAGSNAVGTGAGGAAGGGAPGNGSDSEKDWRESVTADLRNHLVHKLVQAIFPTSDPTTMQDKRMHNLVTYAEKVEKDMYEMAKNRSEYYHLLAEKIYKIQKELEEKRLKRKEQHQQQLLQMQQGGPNSSVVNPTSVPNNALQQQQQPGQGVRPNISPMGGGGGGGGGPSGMMQQQMRPQAPGMGVGVGVGQQQQTAAGQANMVAVAASMRSHSPGGNMLAIQQQQRMQFPQQQQPGQGNMLVGPPGPSPGGMVANPVLSPFNTQQTMQSATAVGGGPGILTSPVPGQQQQQQQQQQQQQQQFINANGSSGAQNSQISEIMKQRLLQHQQQTNAAAMLLPQSPFNNATPIQQPQQQQQQQQQQQQQQQQQQQQQQQQQQTNAFSSPMQQKTQPPGSVLNNMPPTPTSLDALNAGAASAGAGSIGGGTVAAPSPSPSFMSNGPIGTPSNNPPSVSSLMQPLSNRAATPPYIPTSPVPATSASGLTASSTPASAAATCSSSGSGSSTSSSAVVTTTTVTTPLSCASSSGTTPTSTTTSTSGNGSATPASSTLLQMARSNSENSAPGRVMSSSSSLSSQMAALEAAARDNDDETPSPAGANDTNGSNGGSGGGMASKGKLDSIKQEDDIKKKFMDDSCGGNGDSSQMDCSTGGKGKNVNNDGTSMLKMEIKTEVGADVKPIKSDPMDVDESAVSSGIAGGANGDGTIGGSGVDSKDDINGAIDGVSSGLAADIKLKSETKPHVPEPLAPNAGDKKKKCQFNPEELRTALMPTLEKLYRQEPESVPFRYPVDPQALAIPDYFEIVKKPMDLGTIRSNILNGKYSDPWEYVDDVWLMFDNAWLYNRKTSRVYRYCTKLSEVFEQEIDPVMQALGYCCGRKYTFNPQVLCCYGKQLCTIPRDAKYYSYQNRYTFCQKCFNDIQGDTVTLGEDPQQSQTQIKKDQFKEMKNDHLELEPFVDCQECGRKQHQICVLWLDSIWPGGFVCDNCLKKKNSKRKENKFNAKRLPTTKLGVYIETRVNNFLKKKEASAGEVHIRVVSSSDKCVEVKPGMRRRFVEGGEMMQEFPYRAKALFAFEEVDGIDVCFFGMHVQEYGSECPAPNTRRVYIAYLDSVHFFRPRQYRTAVYHEILLGYMDYVKQLGYTMAHIWACPPSEGDDYIFHCHPTDQKIPKPKRLQEWYKKMLDKGMIERIIQDYKDILKQAMEDKLGSAAELPYFEGDFWPNVLEESIKELDQEEEEKRKQAEAAEAAAAANLFSIEDNEVSGDGKKKGQKKAKKSNKSKAAQRKNSKKSNEHQSGNDLSAKIYATMEKHKEVFFVIRLHSAQSAASLAPIQDPDPLLTCDLMDGRDAFLTLARDKHYEFSSLRRAQFSTLSMLYELHNQGQDKFVYTCNNCKTAVETRYHCTVCDDFDLCTVCKEKVGHPHKMEKLGFDLDDGSAPADLKQANPQEARKQSIQRCIQSLVHACQCRDANCRLPSCQKMKRVVQHTKNCKRKTNGGCPICKQLIALCCYHAKHCQEQKCPVPFCPNIKHKLKQQQLQQKLQQQQLLRRRVALMSRTAAPAALPGPAVSGPVVASGAVGVGGPVVGMSGVAVSQQVMSGQAAIMPAGGGGMSPSTVAVPSPVSGAVMAGMTSPHPHQPGIGMKPGGHSPSPNVLQVVKQVQEEAARQQVPHGGSFGKGVPMAPPVMQRPMGVGVSNQGGMGGMVSNVGGNQLAGNVGVVPGGGQLPSGANCNNILNANNLLPLDQWGGSGGPGQQRYTNNAPNQPGMRQPNQLMQQNIQQQQQQMMGMPPNQLGVGVGVGVGAGQMPVVGSGVNMGGGGAPHSIGLGSQIGAAASGGGVRPPGAQGVGGGGAGGAGPNMGNGPPLNTQTLAHIMQKIKNNPTNESNQHILNILKQNPQIMAAIIKQRQQSQINAAAGGAGGPPGAIQAGNGPQTPQQQQQQQQVMQQQQMQHMMNQQQQGPGPGPQQMGPGQQQQVSLMQAAQQQQQGPPHQRMANMQNTAMMLPNLPPGSQGGMVPNQNLNKMRYMPMNQYPPPYPQRQRGPHMGVFGQPPFPGGTAGNFNAGGGGNVSGIPVAGAAVGSGASGPGSDQYSMANAAASNMLQQQQGGGGAGVKPGPQQQQQQQQQQMGVMPPGMQQQQPMQQQQQQQQMMQVVAAGGGGMSSTNPQNTLPGGGGGPSGPGANVMGPPTPHTLQQQLMQSARSSPPIRSPQPTPSPRSAPSPRGPSASPRAQPSPHHVMSSHSPAPQGPHDGLHNHGMHHQSPLPGVPQDVGVSGVGVGVGVGVGVNAGNVGNAGGSLPDASDQLSKFVERL
Length3223
PositionTail
OrganismDrosophila mojavensis (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila.
Aromaticity0.04
Grand average of hydropathy-0.613
Instability index59.25
Isoelectric point8.98
Molecular weight338264.09
Publications
PubMed=17994087

Function

Annotated function Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation. 
GO - Cellular Component
cytoplasm	GO:0005737	IEA:UniProtKB-SubCell
nucleus	GO:0005634	IEA:UniProtKB-KW

GO - Biological Function
histone acetyltransferase activity	GO:0004402	IEA:UniProtKB-UniRule
transcription coregulator activity	GO:0003712	IEA:InterPro
zinc ion binding	GO:0008270	IEA:InterPro

GO - Biological Process
regulation of transcription, DNA-templated	GO:0006355	IEA:InterPro
rhythmic process	GO:0048511	IEA:UniProtKB-KW









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05548
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            16|    1026.82|      64|      64|    1200|    1263|       1
---------------------------------------------------------------------------
  252-  298 (56.53/ 8.43)	.........................................MQ......NGP.MM......GRM...........VG....GQ.QHLLRGP.........H.......LMGGG.......AG..G....GN...G...PGGVVG.........A.GGG..........P.......RM...................Q
  299-  385 (49.76/ 6.28)	NP.NM..QLGQinnmpygvgnygapgsnntqllaQQ.....MAQ..R..GAG.GV......GGV...........VA....PN.MSAGMAQ.........AnrpigtvVPMSN.......LG..GD...GA.........PPG............AGG..........L.......V.........G........NTQ
  386-  433 (50.57/ 6.54)	QQ.QQ..Q................................................................laaAN....AQ.MNS...Q..................QQQQ.......QQ.......PP...G......VQQ.........G.AMG..........P.......RA.......PQpnqllghsQQQ
  587-  671 (74.71/14.21)	QQ.QQ..QQQQ.......................QQqlpqgQQQ..V..PQN.PSgvgvgvGGG...........VG....VG.VGVGVDT.........K.......QVAQS.......AG..TC...GApntA...IVLPQQ.........Q.AAG..........AsnvpkgnTD.......MG........QQQ
  672-  725 (58.95/ 9.20)	QQ.QQ..HQQV.......................QQ.....QELrrF..EGV.GS......IG...................Q.VGPV.PA.........G.......MLGAP.......GQ..GM...AP...G...IRMQGA.........P.SVR..........V.............................
  766-  846 (51.94/ 6.97)	QQ.QQaaQAAQ.......................QS.....GQL..MlqGCN.TG......TGG......rrralQNmvdqQQ.QPNAQQQ.........S.......VQQQQ.......QQqlGN...IP...A...PLSVNV.........G.FNN..........A.......NF.....vgVG........DKQ
  847-  898 (52.03/ 7.00)	QQ.QQ..QQQQ.......................QQ.....QQL........vG.....................QS....DQ.MTKLKLQ.........A.......QAQAQ.......VQ..AHvnvVS...A...GGAPGS.........G..NS..........A.............................
 1060- 1141 (67.87/12.03)	QQ.QQ..PGQG.......................VR.....PNI..S..PMG.GG......GGG............G....GG..PSGMMQ.........Q.......QMRPQ.......AP..GM...GV...G..vGVGQQQ.........QtAAG.....qanmvA.......VAasmrshsPG..gnmlaiQQQ
 1142- 1206 (63.86/10.76)	QRmQF..PQQQ.......................QP.....GQ.......GN.ML......VGP...........PG....PS.PG..............G.......MVANPvlspfntQQ..TM...QS...AtavGGGPG.............................iltsPV.......PG........QQQ
 1207- 1273 (85.60/17.67)	QQ.QQ..QQQQ.......................QQ.....QQF..I..NAN.GS......SGA...........QN....SQ.ISEIMKQ.........R.......LLQHQ.......QQ..TN...AA...A...MLLPQS.........P.FNN..........A......tPI.....qqPQ........QQQ
 2570- 2613 (51.55/ 6.85)	QV.QE..EAAR.......................Q.......Q...V..PHG.GS......FG..................KG.VPMAPP..................VMQRP............M...GV...G...VS..NQ.........G.GMG..........G.............................
 2686- 2750 (67.42/11.89)	QQ.NI..QQQQ.......................QQ.....MMG..M..PPN.QL......GVG...........VG....VG.VGAGQMP.........V.......V...G.......SG..VN...MG...G...GGAPHSiglgsqigaA.ASG..........G.......GV....................
 2851- 2885 (68.46/12.22)	QQ.QQ..VMQQ.......................QQ.....MQH..M...............MN...........Q............QQQ...........................................G...P.GPGP.........Q.QMG...........................PG........QQQ
 2886- 2951 (68.21/12.14)	QV.SL..MQAA.......................QQ.....QQ......QGP.PH......QRM...........AN....MQ.NTAMMLP.........N.......LPPGS.......QG..GM...V...........PNQ.........N.LNKmrympmnqypP.......PY.......P.........QRQ
 2961- 3032 (64.17/10.86)	QP.PF..PGGT.......................AG.............NFN.AG......GGGnvsgipvagaaVG....SGaSGPGSDQysmanaaasN.......MLQQQ.......QG..G....GG...A...GVKPG..........................................PQ........QQQ
 3049- 3105 (95.18/20.71)	QQ.PM..QQQQ.......................QQ.....QQM..M..QVV.AA......GGG..................G.MSSTNPQ.........N.......TL..P.......GG..G.....G...G...PSGPGA.........N.VMG..........P.......PT.......PH........TLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     427.35|     105|     205|    1310|    1419|       2
---------------------------------------------------------------------------
  903-  953 (41.91/ 6.65)	SVL..MPADTT......GGA........NSASA....GSNA..VGTGAG..........GA.....A..GGGapGNGSDS.............EKDwrE..........SVTA........................................................
 1312- 1418 (186.71/69.90)	SVLNNMPPTPTSLDALNAGA........ASAGA....GSIG..GGTVAA..........PSPSPSFM..SNG..PIGTPS.............NNP..P..........SVSSLMQPLSNRA.ATPPYI..PTSPVPATSASGLtaSSTPAS......AAATCSSSGSG
 1419- 1480 (60.41/14.32)	................................................................SST..SSS..AVVTTT.............................TVTT...PLSC.A.SSSGTT..PTSTTTSTSGNG...SATPASstllqmARSNSENSAPG
 1482- 1626 (98.61/31.88)	.VMSSSSSLSSQMAALEAAArdnddetpSPAGAndtnGSNGgsGGGMASkgkldsikqeDDIKKKFMddSCG..GNGDSSqmdcstggkgknvNND..GtsmlkmeiktEVGADVKPIK....SDPMDV..DESAVSSGIAGG.......AN......GDGTIGGSGVD
 3120- 3164 (39.71/ 7.37)	................................................S..........PQPTPSPR..SA.......PS.............PRG..P..........SAS....P...RAqPSPHHVmsSHSPAPQGPHDGL.........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     371.14|      65|      78|      42|     118|       4
---------------------------------------------------------------------------
   42-  106 (124.51/33.05)	QLNTGGGGGGGVGGVVSTASGVVGAGGPNKPPTQGPG.PGV.VPPQMNG......AGGGGDDGSG.NGGSGAAG
  123-  185 (89.24/28.65)	QHQQQGNKGAG.GGMVVPGMNQLGSKSPN...LQSPNtAGMqVATQMGM......VNSMPMSISN.NGNNGMNS
 2476- 2526 (56.55/10.00)	........GPAVSGPV.VASGAVGVGG...PVVGMSG.VAV.SQQVMSGqaaimpAGGGGMSPS........T.
 2527- 2563 (54.33/ 9.20)	............VAVPSPVSGAVMAGMTSPHPHQ.PG.IGM.KP..............GGHSPSP.N.......
 2614- 2648 (46.50/ 6.38)	..............MVSNVGGNQLAG..........N.VGV.VP............GGGQL.PSGaNCNNILNA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     130.10|      27|      83|    2301|    2328|       5
---------------------------------------------------------------------------
  526-  552 (38.51/20.79)	CpmQHCTSSRQILLHYKTC..QRSD.CIIC.
 2301- 2327 (50.33/31.07)	C..NNCKTAVETRYHCTVC..DDFDLCTVCK
 2388- 2413 (41.27/23.19)	C..QKMKRVVQ...HTKNCkrKTNGGCPICK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     235.69|      53|      61|    2040|    2092|       7
---------------------------------------------------------------------------
 1970- 2019 (65.46/39.61)	...GEM..MQE.FPYRAKALFAFEEVDGIDVCFfgmHVQEYGSECPAPNT.RRVYIA
 2040- 2092 (98.54/63.78)	ILLGYMDYVKQ.LGYTMAHIWACPPSEGDDYIF...HCHPTDQKIPKPKRLQEWYKK
 2102- 2152 (71.68/44.16)	IIQDYKDILKQaMEDKLGSAAELPYFEGD...F...WPNVLEESIKELDQEEEEKRK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.37|      15|    1756|    1290|    1304|      14
---------------------------------------------------------------------------
 1290- 1304 (30.75/11.28)	QQQQQQTNAFSSPMQ
 3033- 3047 (33.61/13.20)	QQQQQQMGVMPPGMQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.58|      18|     469|    2346|    2363|      16
---------------------------------------------------------------------------
 2346- 2363 (33.36/13.75)	GSA...PADLKQAN.PQEARKQ
 2828- 2849 (24.22/ 7.59)	GGAggpPGAIQAGNgPQTPQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.28|      40|     201|    1629|    1670|      17
---------------------------------------------------------------------------
 1629- 1670 (64.39/50.65)	DDINGaiDGVSSG.....LAADIK...LKSETKPHVP.EPL..APNAGDKKKK
 1830- 1880 (53.90/35.29)	NDIQG..DTVTLGedpqqSQTQIKkdqFKEMKNDHLElEPFvdCQECGRKQHQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.74|      14|      15|    2779|    2792|      20
---------------------------------------------------------------------------
 2779- 2792 (25.08/14.11)	QTLAHIMQKIKNNP
 2795- 2808 (24.66/13.75)	ESNQHILNILKQNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.18|      10|     845|     434|     443|      29
---------------------------------------------------------------------------
  434-  443 (19.65/ 6.49)	QQQQQPGTSQ
 1280- 1289 (19.53/ 6.38)	QQQQQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      72.92|      14|     432|     311|     324|      30
---------------------------------------------------------------------------
  311-  324 (27.31/11.93)	PYGV.GNYGAPGSNN
  730-  743 (24.93/ 9.96)	PGQP.GSTMASGGVP
  745-  759 (20.68/ 6.44)	PVPVpGQNVLPGAND
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05548 with Med15 domain of Kingdom Metazoa
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