<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05540

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPTPLPLEQMPGANAGYLPAGQEGGPRINTMSMSVLIDFIIQRTYHELMVLAELLPRKTDMERKVEIYAYAARTRHLFTRLNALVKWGNSVSKVDKSSQIMSFLDKQNMLFVETADMLARMSRETLVRARLPNFHIPAAVEVLTTGTYNRLPTCIRERIVPPDAITPAEKRQTLLRLNQVIQHRLVTGKLLPQMREFRIRNGRVTFEVKHEFSVALTVMGDSPNVPWRLLDIDVLVEDKETGDGKSLVHPLQVNYIHQLIQARLVENPNALSEVYNCLHYFCQSLQLEVLYTQTLRLNYERLDDNNITVEEYVPGVKLTVSYWRDLKSELGYRLTVQSDPSEIGRPLVVVHVPSLGAKESAEVADRAVRSEHLSMERLIVHTVYIRSVSRLSDLKLEFQAFLKDVDFNLQGTPAILTVPVLSPCLRAEQIHITIDTHTGMFRCHVPKHLDCPITEEMQDCLNTDRSKLPALLSELRYWITHRRCEKTLQHLPATATETLPFLTLPEQELLQPGRHKIYVKLHRHPNIILVVQLKEKPAMPNEMEYTFHLGFVVFQKDENDVVDDSAKQLVSIVAQPPSEIPKLYTKLMRLIEFDTFVATHGPGTEVDEVSPHKRKSNGDILAPPAKQQKTIFPAYFIPELAHVVAMCDEKIPFLNLAQTLAKYRIPHSGLQVEANATSLVLKILALPQPGTNNQATTATGEQKPTPAPSTSSALPKIEPHVWDDLMRRVLSISVRSQTNKNSQVRIWVVEFVFYSTPLQSTHQKELGSRRTINLTYEQANHDFSKTVEDLLNDWSKIVYLYTLVYDFAEQLRNKRLSLGDMLVVKSYTYANLLLGYGPKKEVTCNIYWSVQSHGFRLTFVGGISAVNAHSMMRDQLAQHLNQQHSLTTIAHILHETYNPMSSIAKLPVLPLLGIPRPQVPVLSFCMLPQSPCLMRLTYQAVYCLELRFRANRLVSIRDGASSRFERNVIEEFTPIQGLKAFLSKYVDESAVYRGRAPHDDDNPLSPMGLEDNFGGPSSVTGVSAGGSSPFLGAGMRGPQSPRDSGLRFPAPHTPPSSSNPHTPASPHPSAGGGGGGGAQSHANFNLTSPPAPHMPHPSPGGLMPSSPLNPQPSPHMVHSPGPNTLYMQSHQDSPFTAMSPANNNWPGSPSMPRPSPRPGQSPEHKSTGGGGPGVGAADRNVTRGTLNRPWAGAVPTLLTHEALETLCRPSPHPNKDINVADMSPLERFLGCVYMRRQLHRNIQSEETLTALNSTEPGVVLFKVDGLQCQVMLNQLHMQSLHLKVTQLPPMPDKPTFQLSPDDLLVIEQYFDTRVAAPPYRPNALHSICRLLNLPGHVLKDFVQIMRLEMKPELGGDQLKWTVQMCMRMSPSAMPIVPIGSACVVLGRMKILFFLHITRIPYNGKDWKDSPSLVLPIVHDIATNLTQVAERREQVQSPTMSAASALLRRFADFGVQQNQCSLFPAVTELLTNLQITTDLPPPPPNQPIGPPVGVGVGVGVGVGVVGSSPNTMMPMQQLQPQVGHGPQLGPNPGGPQ
Length1536
PositionTail
OrganismDrosophila virilis (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila.
Aromaticity0.06
Grand average of hydropathy-0.248
Instability index53.98
Isoelectric point8.46
Molecular weight170839.80
Publications
PubMed=17994087

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05540
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     151.27|      29|      39|    1040|    1069|       1
---------------------------------------------------------------------------
 1040- 1069 (58.46/22.91)	QSPRDS..GLR..F.PA....PHTP..PSSSnPHTPASP.HP
 1080- 1098 (33.88/ 8.90)	QSHANF..NLT..SpPA....PHMP...............HP
 1099- 1123 (27.51/ 6.03)	.....SpgGLM..P.SS....PLNP.qPS...PHMVHSP.GP
 1129- 1165 (31.42/ 7.80)	QSHQDS..PFTamS.PAnnnwPGSPsmPRPS.PRPGQSPeH.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.65|      10|      95|    1070|    1079|       2
---------------------------------------------------------------------------
 1070- 1079 (22.43/ 9.30)	SAGGGGGG.GA
 1167- 1177 (18.22/ 6.36)	STGGGGPGvGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.61|      11|      23|     151|     161|       3
---------------------------------------------------------------------------
  151-  161 (20.38/11.73)	RLPTCIRERIV
  177-  187 (19.24/10.68)	RLNQVIQHRLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.87|      49|     103|     199|     251|       4
---------------------------------------------------------------------------
  199-  251 (77.20/67.73)	RIRNGRVTFEvKHEFSVALTV..MGD.SPNVPWRLldiDVLVEDKETGDGKSLVH.P
  302-  354 (72.67/50.72)	RLDDNNITVE.EYVPGVKLTVsyWRDlKSELGYRL...TVQSDPSEIGRPLVVVHvP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.57|      13|      54|    1287|    1304|       5
---------------------------------------------------------------------------
 1287- 1301 (23.48/ 9.63)	QLPPMPdkPTFQLSP
 1478- 1490 (29.09/ 8.06)	DLPPPP..PNQPIGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.31|      28|     480|    1007|    1039|       6
---------------------------------------------------------------------------
 1007- 1039 (49.36/38.35)	PMGLEDNFGgpssvTGVSAGGSSP.................FLGAGMRGP
 1491- 1535 (43.95/23.27)	PVGVGVGVG.....VGVGVVGSSPntmmpmqqlqpqvghgpQLGPNPGGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.83|      16|     480|     410|     426|       7
---------------------------------------------------------------------------
  410-  426 (27.25/17.96)	LQGTPAIlTVPVLSPCL
  912-  927 (32.57/17.80)	LLGIPRP.QVPVLSFCM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05540 with Med14 domain of Kingdom Metazoa
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