<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05539
Description |
Mediator of RNA polymerase II transcription subunit 13 |
Sequence | MSPHAPTSVSNLQQPPTPIDHLLDKNTPAPTPTDQHDNKSITASPYVHQTPSVEPPTYAEHGNAAGGGGSQSLNAAPGSVPQQPATPTPATAGAAATTTATTTTSATAAGTGTAGAATGAGAGAGGATQCGTISVKKLEMQQQAPQQVLAIKQEPGLARISQVQQQQQQQVPLASSALEAVTNLFNLYKPPQLTLKDGDSVYDEEWLKDVYDFSFQETWDNLPVKRPKLNESAKQRRPRYARNLYEGHTHFKPLMPSPGSVYGPLLSIEGSAAALGAAGEGSSSGGGGGGLVGIAGGAGAGAGGAYGGASSADEADNALGGSGSGSGSGNMTATTTGNSFFQGLDIKTEPGLHSPCKESKSTSTAGSGSAGNNLFTAEGLNPSLNDLEQLFETSSNDECSSVQIHTPPDSNNPSNGGCSAVSNTIDELKRSTAVASAVVAAVVASSGAGSIQAEDLTKMFPTPPSHEQQHPNSSPCQTDVVMTDLSVDTTTNNSSSTTTNVGVAVGLGVVLKMVKQEYSVELGSPVEEPIDDWSYVYRPPQQEKFVGSSRYAPLTNLPSQTQPPLQIPANCYYNPTWSHSQKSRAATLAKAAAAQQQQQQLQKHQQLQQRIQQHQQLQQQHQQQQLQLQQQQQQQHKHQQLHELLSAGPRTPMNAAMPSPSTTTTATTTVPQPLSSGGSQLLLNQLNCPQAPPGSSMQQLMQRAGMSPIPSPGGPGVVPFPRSSPMHLGGMRQTPTHPPPPYPYELAAASPATSTSSYLNKQYNSQEPPGHPHTPQSVHHVMFGPMSAGAGGSGGAGAGLMPAGDGSKLAMMQYSGGGAGSTGLGSSSSSSVAAAAAAAAAAMSLLQELPEVNSVLINILLYDTALNVFRDHNFDSSSVCVCNADTQKIGNIRGADSGLYVPLPGSSFNPFPSQRLLNSHPAGTPYNPFGGSASGGGGGGGGGGGGMRMISAFGGGLDSSPVAALSGAGSVHHGHGPNGGSSSSSCTPPSSNPHITGYVDDDPVECTCGFSAVVNRRLSHRAGLFYEDELEITGIVDDPARHKQPTLLSLIQSLCRKGNNNHNHNHNNKSVNEPVGKELEKLTTTTTTTSGQQQQQQQLEQLAHAIFDLLLDQCSIIQTSSSSVHRALQSHRRRMSRQRRLFGQNSASLASIANVLEFTDAHDVVSLALEQARLAFESQRMDMNMLEFGHNNHHGQQHNPHQHSQHPHHPHQPHPAQHSQQLTAFQAAPALRQKLLVLGSSRLTVHKWPYLPVGFTRSNKEIVRTMNAIQPMLQSAFHCKSRGGAAGSKDASSYNTVSGPLTWRQFHRLAGRASGQCEPQPIPSVVVGYEKDWISVAPHSIHYWDKFLLEPYSYARDVVYVVVCPDNEHVAASTRTYFRELSSTYEMCKLGRHTPIRGWEGVLQVGTEREAPLTPLDDWLRTLDHAPLAEQIRRYAVAFLYQLAPYLSRVPGDKTLLNPPDASASGSHSTKAPGAVPPSAAEHPHEPVIKLEPGTEPTPATQSSSNSSSGGAGGAGQEQDSKADVKAGGDSKPALVLGDPLGMGETLEDINPSAIVLYVVNPFTFASDSFELERLALIALLRCYAELLKAVPDSVRAQMNIQIISLEAIMELGPCGNRRRFSDEIKCLALNIFSQCRRHLVHAQPVKSLTGFGTAANMEAFLKTKDEPNRRAYKMYTAPFVLAPMHERNDKTDFSRAAGSMHGQNETRYSVMYCNYCLSEDQSWLLATATDERGELLEKVCINIDVPNRARRRKAPARYVALRKLMDFVMGLISQTSQMWRLVIGRIGRIGHSELKSWSYLLSKQQLQKASKQFKDMCKQCTLMYPPTILSACLVTLEPDAKLRVMPDQFTPDERFSQISMQNPLSTPQDVTCTHILVFPTSAVCASFTRQFQNEPQVDDDFIFGEEEGNEDFSDADIGDLFWDSAHMDRVSNHGSPGRMEDNRSWQSAGGNNFKCTPPQEVEEVGSLNQQPISVGYMVSTAPTGRMPAWFWSACPHLEDVCPVFLKTALHLHVPNIQIADDILNSTNAHQSANDHPLDSTLTADVLRFVLEGYNALSWLALDSNTHDRLSCLPINVQTLMDLYYLTAAIA |
Length | 2091 |
Position | Middle |
Organism | Drosophila virilis (Fruit fly) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota>
Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea>
Drosophilidae> Drosophila.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.429 |
Instability index | 54.67 |
Isoelectric point | 6.17 |
Molecular weight | 223756.31 |
Publications | PubMed=17994087
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364134
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP05539
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 82.75| 16| 16| 596| 611| 1
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596- 611 (31.62/14.67) QQQQQLQ.KHQQLQQRI
612- 628 (27.97/12.17) QQHQQLQqQHQQQQLQL
630- 643 (23.16/ 8.88) QQQQQQH.KHQQLHE..
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
6| 1112.25| 355| 648| 3| 380| 2
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15- 213 (255.17/99.74) .......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PPTPIDHLLDKNT.PAPTPT.......................................................................................DQHDNKSIT....ASPYVHQTPSVEPPTYAEHGNAAGGGGSQSlnaAPGSVP....QQPATP....TPATAGAAATTTATTTTSATAAGTGTAGAATG..AGAGAGGATQCGTISVKKLEMQQQAPQQVLAIKQEPGLARISQVQQQQQQQVPLASSALEAVTNLFNLYKPPQLTLkDGDSV......YDEEWLKDVYDF
214- 380 (176.22/69.75) SFQETWDNLPVKRPKLNESAKQRRPRYA.RNLYEGHTHF......KPLMPsPGSVYGP.....LLSIEGSAAALGAAGEGSSSGGGGGGLvGiAGGAGAGAGGAYGGA..SSADEADNALG....GSGSGSGSGNMTAT.TTGNSFFQGLdIKTEPgLHSPCKESKSTSTAGSGSAGnnLFTAEGL................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
468- 577 (98.30/26.20) ...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................npslndleqlfetssndecssvqihtppdsnnpsnggcsavsntidelkrstavasavvaavvassgagsiqaedltkmfptppsheQQHPNSSPC....QTDVVMTDLSVDTTT.............................................................NNSSSTTTN..VGVAVG....LGVV....LKMVKQEYSVELGSPVEEPIDDWSYVYRPPQQEKFVGSSRYAPLTNLPSQTQPP.LQI.PANCY......YNPTW.......
647- 872 (346.75/120.07) AGPRTPMNAAMPSPSTTTTATTTVP....QPLSSGGSQLllnqlnCPQAP.PGSSMQQ.....LMQ.........RAGMSPIPSPGGPGV..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................vPFPRSS.......................................................................................PMHLGG...........MRQTPTHPPPPYPYELAAASPATSTS.....SYLN....KQYNSQ....EPPGHPHTPQSVHHVMFGPMSAGAGGSG...G..AGAGLMPA...GDGS..KLAMMQYS..........GGGAGSTGLGSSSSSSVAAAAAAAAAAMSL..LQELPEV.....NSVlinillYDTA.LNVFRDH
873- 1030 (161.74/49.89) NF....DSSSVCVCN.ADTQKIGNIRGAdSGLY............VPL...PGSSFNPfpsqrLLNSHPAGTPYNPFG.GSASGGGGGG..G.GGGGGMRMISAFGGGldSSPVAALSGAGsvhhGHGPNGGSSSSSCTpPSSNPHITGY.VDDDP.VECTCGFSAVVNRRLSHRAG..LFYEDEL................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
1412- 1543 (74.07/17.17) ..........................................................................................................................................................................................eitgivddparhkqptllsliqslcrkgnnnhnhnhnnksvnepvgkelekltttttttsgqqqqqqqleqlahaifdllldqcsiiqtssssvhralqshrrrmsrqrrlfgqnsaslasianvleftdahdvvslaleqarlafesqrmdmnmlefghnnhhgqqhnphqhsqhphhphqphpaqhsqqltafqaapalrqkllvlgssrltvhkwpylpvgftrsnkeivrtmnaiqpmlqsafhcksrggaagskdassyntvsgpltwrqfhrlagrasgqcepqpipsvvvgyekdwisvaphsihywdkfllepysyardvvyvvvcpdnehvaastrtyfrelsstyemcklgrhtpirgwegvlqvgtereaPLTPLDDWLRTLD.HAPLAE.......................................................................................QIR.RYAVAflyqLAPYLSRVPGDKTLLNPPD.ASASGSHSTK...APGAVPpsaaEHPHEPviklEPGTEP.TPATQSSSNSS..SGGAGGAGQEQDskADVKAGGDSKPALVLGDPLGM...............................................................................
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 172.62| 52| 166| 1827| 1879| 3
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1827- 1879 (89.02/58.99) PTILSACLVTLEPDAKLRVmPD.QFTPDERFSQISMQNPLSTPQDVTCT.HILVF
1996- 2049 (83.59/50.50) PHLEDVCPVFLKTALHLHV.PNiQIADDILNSTNAHQSANDHPLDSTLTaDVLRF
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