<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05537

Description "Uncharacterized protein, isoform C"
SequenceMMADHLDEPPQKRAKIDQSTLRFLEENLPDELVSSNSGWSDQLSTTGGGVNVVSTATGVGTGGPNKPPTQGPGSGVVPPQMNGAGGGGDDGSGNAGSGAAGSQLRQMQHHQHLQHFLQQQQQGNKGAGGGMVVPGMNQLGSKSPSLQSPNTGGIQVTTQMGMVNSMPMSISNNGNNGMNAIPGMNSIAQGNLGNMVLTNSGGMGTIGGTGLVNTLKQPVAASLMNAVPGSVGVSSVSGAAPSQGMHMQNGPMMGRMVGQQHLLRGPHLMGAGASGGSGPGGVVGVGGGPRMQNPNMQLGQINNMPYGVGNYGTPSSNNPQQQQQLLAQQMAQRGGGGVVAPNMSAGMPQGNRPIGTVVPMSSLGGDGPPPGSGGLVGNPQQQQQLAAANAQMNPQQQQQPPSAQQSALGPRAPQPNQLLGHSQQQQQQPGTSQQQAISSGVASSVSGPAPAPGSMSDERKKQIQQHLMLLLHAHKCNRRENMNPNREVCSVNYCKAMKAVLAHMATCKQSKDCTMQHCTSSRQILLHYKTCQRSDCIICYPFRQNHSLFQNASGAGGGPTGAANASPLQQQQQQQQLAQGQPQVSQNPSGVGVGVGVGVDSKQVAQSTGTGGTQNTAIVLPQQQTPGATNVPKSNTDLAQQQQQQVQQQELRRFESVGSIGQVGPVSAGMLGVPGQGMPPGIRMQGTPSVRVLGVQPGAGGAISGGVPVPGQNVLPGANDVTSLQQQQAQAAQQGGQLMLQGCNTSTGRRRAIPNMVEQQPNAQQSVQQQQQLGNIPAPLSVNVGFNNANFVGVGEKQQLGSQSDQMAKLKLQAQSQAQVQAHVSVVSAGAPGTGNSTAGASVLMPADTTGVANSSSSGSNSSNAGAGSAGSAGGAGGAPGSGSDSEKDWRESVTADLRNHLVHKLVQAIFPTSDPTTMQDKRMHNLVSYAEKVEKDMYEMAKSRSEYYHLLAEKIYKIQKELEEKRLKRKEQHQQQMLQMQQGGPNSGVVNPTSVPNNSLQQQPGQGVRPIISPMGSGGGGPSGMVQQQMRPQAPGMGSGASQQQTAAGQANMVAVAASMRSHSPGGNMLAIQQQQQRMQFPQQQQPVQGNMLVGPSGPSPGGMVANPVLSPFNTQQTMQSASSVGGGPGILTSPVTAQQQQQQQQQQQQQQQQQQFINANGSSGGQNSQISEIMKQRLLQQHQQQTNAAMLLPQSPFSNATPIQQPQQLQQQSNAFNSPMQQKAQQPPGSVLNNMPPTPTSLDALTAGAPNAGAGGIGSGTVTAPSPSPSFMSNGPIGTPSNNPPSVSSLMQPLSNRAATPPYIPTSPVPATSASGLAASSTPASAAATCANSGSSSNISSTSSSVITTTAVTAVVSTPISCASGATQTSTTATSGNVNSTPVSSTVLLVARSNSDNTATGRVMSTSSSLSSQMAALEAAARDNDDETPSPAGANDTNGSNGGGSSGGGGMSSKGKLDSIKQEDEIKKEFMDDSCGGNGDSSQMDCSTGGKGKNVNNDGTSMLKIDLKSEDGAAGDVKIKSEPMDVDESAVVGGIATGANGDGGGGSDGKDDINGAIDGVSAGIASDIKIKSETKPMVPEPLAPNAGDKKKKCQFNPEELRTALLPTLDKLYRQEPESVPFRYPVDPQALGIPDYFEIVKKPMDLGTIRNNILNGKYSDPWEYVDDVWLMFDNAWLYNRKTSRVYRYCTKLSEVFEAEIDPVMQALGYCCGRKYTFNPQVLCCYGKQLCTIPRDAKYYSYQNRYTFCQKCFNDIQGDTVTLGDDPLQSQTQIKKDQFKEMKNDHLELEPFVDCQECGRKQHQICVLWLDSIWPGGFVCDNCLKKKNSKRKENKFNAKRLPTTKLGVYIETRVNNFLKKKEAGAGEVHIRVVSSSDKCVEVKPGMRRRFVEGGEMMQEFPYRAKALFAFEEVDGIDVCFFGMHVQEYGSECPAPNTRRVYIAYLDSVHFFRPRQYRTAVYHEILLGYMDYVKQLGYTMAHIWACPPSEGDDYIFHCHPTDQKIPKPKRLQEWYKKMLDKGMIERIIQDYKDILKQAMEDKLGSAAELPYFEGDFWPNVLEESIKELDQEEEEKRKQAEAAEAAAAANLFSAEDNEVSGDGKKKGQKKAKKSNKSKAAQRKNSKKSNEHQSGNDLSAKIYATMEKHKEVFFVIRLHSAQSAASLAPIQDPDPLLTCDLMDGRDAFLTLARDKHYEFSSLRRAQFSTLSMLYELHNQGQDKFVYTCNNCKTAVETRYHCTVCDDFDLCTVCKEKVGHPHKMEKLGFDLDDGSAPADLKQANPQEARKQSIQRCIQSLVHACQCRDANCRLPSCQKMKRVVQHTKNCKRKTNGGCPICKQLIALCCYHAKHCQEQKCPVPFCPNIKLKLKQQQLQQKLQQQQLLRRRVALMSRTAAPTALPGPAVSGPVVAAGGVGVGVPVVGMSGVAVSQQVMSGPASILPSSGGGMSPSTVPVPSPVSGAVIAGMTSPHPHQPGIGMKPGGHSPSPNVLQVVKQVQEEAARQQVPHGGSFGKGVPMAPPVMQRPMGVGVPNQGAMGGMVGNQLTGNVGVVPGGGQMPSGGNCNNVLNSNNLLPMDQWGGGGGPQQRYANNTPNQQGMRQPNQLMQQNIQQQQMLGIPSNQLGVGVGVGGSVGTGQMPVVGAGVSMGGGGAAHGIGLGAPIGAATSGGGVRPPGAQGVGGGGTGGAGPNMVNGPPLNTQTLAQIMQKIKNNPTNESNQHILSILKQNPQIMAAIIKQRQQSQINAAAGGAGGAGGALQAGNGPQTPQQQQQQQQVMQQQQMQHMMNQQQQGPGPGPQQMGPGQQQQVSLMQGAQQPQQGPPHQRMANMQNTAMMLPNLPPGITNQGGMVPNQNWTKMRYMQMNQYPPPYPQRQRGPHMGVAGQPQFPGGTTGNFNAGSAGNVTGVQVAGTTVGSGAAGTVSDQYSMANAAASNMLQQQQTVGGAGVKPVPQQQQQQMGVIPPGMQQQPMQQQQQQQMMQAVAAGGGGMTGTNPQNALPGGSSGPTGPGSNVMGPPTPHTLQQQLMQTARSSPPIRSPQPTPSPRSAPSPRGPSASPRAQPSPHHVMSSHSPAPQGPHDGLHNHGMHHQSPLPAVPQDVGVSGVSVGVNAGNVGNAGGSLPDASDQLSKFVERL
Length3132
PositionTail
OrganismDrosophila virilis (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila.
Aromaticity0.04
Grand average of hydropathy-0.568
Instability index55.16
Isoelectric point8.98
Molecular weight329283.57
Publications
PubMed=17994087

Function

Annotated function Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation. 
GO - Cellular Component
cytoplasm	GO:0005737	IEA:UniProtKB-SubCell
nucleus	GO:0005634	IEA:UniProtKB-KW

GO - Biological Function
histone acetyltransferase activity	GO:0004402	IEA:UniProtKB-UniRule
transcription coregulator activity	GO:0003712	IEA:InterPro
zinc ion binding	GO:0008270	IEA:InterPro

GO - Biological Process
regulation of transcription, DNA-templated	GO:0006355	IEA:InterPro
rhythmic process	GO:0048511	IEA:UniProtKB-KW









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05537
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            13|     832.66|      65|      65|    1059|    1123|       1
---------------------------------------------------------------------------
  255-  321 (49.33/ 7.37)	...RM..V.....GQ...................QHLLRGPH.LMGagA.S....GGSgP..G...GVVgvgGGPRMQNPNMQ.....LGQI..........NNMPY............GvgnygTP..S.....S.N.............NP..QQ
  424-  500 (45.60/ 6.09)	QQQQQPGT.....SQ...................QQAISSGV.ASS..V.S....GPA.P............APGSMSDERKK...QIQQHL...mlllhahKCNRR............E.....NM..N.....P.NrevcsvnyckaMKAV....
  571-  641 (58.15/10.39)	QQQQQQLA.....QG...................QPQVSQN.......P.S....GVG.V..GvgvGVD...SKQVAQSTGTG...GTQNTAivlpqqqtpgA...T............N.....VP..K.....S.N...........TDLA..QQ
 1016- 1075 (72.38/15.27)	MGSGGGGP.....SG...................M..VQQQM...R..P.Q....APG.M..G...SG....ASQQQTAAGQA...NMVAVA..........ASMRS............H.....SP..G.....G.N...........MLAI..QQ
 1076- 1141 (100.95/25.07)	QQQRMQFP.....QQ...................QQPVQGNM.LVG..P.S....GPS.P..G...GMV...ANPVLSPFNTQ...QTMQSA..........SSV.G............G.....GP..G...ilT.S...........PVTA..QQ
 1142- 1207 (68.15/13.82)	QQQQQQ.......QQ...................QQQQQQQQ.FIN..A.N....G.S.S..G...G.....QNSQISEIMKQ...RLLQQH....qqqtnaAMLLP............Q.....SP..F.....S.N...........ATPI..QQ
 2428- 2493 (65.46/12.90)	SQQVMSGP.asilPS...................SGGGMSPS.TVP..V.......PS.PvsG...AVI...AGM.TSP.HPH...Q.PGIG..........MKPGG............H.....SP..S.....P.N...........VLQV..VK
 2532- 2576 (55.55/ 9.50)	QGAMGGMV..........................GNQLTGNV.............GVV.P..G...G......GQMPSGGNCN...NVLNS.............................................nN...........LLPM..DQ
 2577- 2664 (47.82/ 6.85)	WG.GGGGP.....QQryanntpnqqgmrqpnqlmQQNIQQQQ.MLG..I.PsnqlGVG.V..G....V.....GGSV.GTGQM...PVVGAG..........VSMGG............G.....GA..AhgiglG.A...........PIGA..AT
 2665- 2737 (47.20/ 6.64)	SGGGVR.P.....PG...................AQGVGGGG.T......G....GAG.P..N....MV...NGP...PLNTQtlaQIMQKI..........KNNPTnesnqhilsilkQ.....NP..Q.....I.............MAAIikQR
 2795- 2861 (78.24/17.28)	PQQMGPGQ.....QQ...................QVSLMQGA.QQP..Q.Q....GP..P..H...QRM...ANMQNTAMMLP...NLPPGI..........TNQGG............M.....VP..N.....Q.N........wtkMRYM..QM
 2951- 3015 (82.56/18.76)	QQQQQMGVippgmQQ...................QPMQQQQQ.QQM..M.Q....AVA.A..G...G.....GG..MTGTNPQ...NALPGG..........SS.GP............T.....GP..G.....S.N...........VMGP..PT
 3020- 3088 (61.27/11.46)	QQQLMQTA.....RS...................SPPIRSPQpTPS..PrS....APS.P..R...GPS...ASPRAQP.SPH...HVMSSH..........S.PAP............Q.....GPhdG...lhN.H...........GMHH..QS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     282.84|      72|      73|    1239|    1311|       2
---------------------------------------------------------------------------
 1245- 1317 (117.80/40.48)	DALTAGAPNAGAGGI..GS.GTVTA.PSP....SPSFM..SNGPIGTPSNNPPSVSSLMQPLSNRAATPPYIPTSPVpATSAS
 1318- 1385 (71.88/22.88)	.GLAASSTPASAAATcaNS.GSSSNiSST....SSSVI..TTTAVTAVVSTPISCASGATQTST.TATSGNVNSTPV......
 1393- 1437 (54.18/16.14)	.................................ARSNS..DNTATGRVMSTSSSLSSQMAAL..EAAARDNDDETPS.PAGAN
 1439- 1489 (38.98/ 9.07)	TNGSNGGGSSGGGGM..SSkGKLDS.IKQedeiKKEFMddSCGGNGDSSQMDCS.............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     111.65|      23|      23|    2290|    2312|       3
---------------------------------------------------------------------------
 2226- 2250 (31.60/19.19)	NNCktaVETRYHCTVC.DDFDlCTV..C
 2290- 2312 (46.47/32.40)	QRC...IQSLVHACQC.RDAN.CRLPSC
 2316- 2336 (33.59/20.96)	KRV...VQ...HTKNCkRKTN.GGCPIC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     100.48|      21|      23|      45|      65|       4
---------------------------------------------------------------------------
   45-   65 (35.10/12.13)	TTGGGVNVVSTA.TGVGTGGPN
   69-   90 (38.62/14.34)	TQGPGSGVVPPQmNGAGGGGDD
 2396- 2414 (26.76/ 6.89)	TALPGPAVSGPV.VAAGGVG..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.83|      23|      23|    1514|    1536|       5
---------------------------------------------------------------------------
 1528- 1553 (35.81/16.11)	VDESAVVGGiatGANGDGGGG.SDGKD
 3097- 3123 (29.02/11.25)	VGVSGVSVGvnaGNVGNAGGSlPDASD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     390.71|      69|      69|     705|     773|       6
---------------------------------------------------------------------------
   93-  160 (79.37/22.76)	..GNAG.................SGAA...GSQL.RQMQHHQHLQHFL...........QQQQQGnkgagGGMVVP.GMNQ.L..GSKS.PSLQSPNTGGIQVTTQM..
  676-  740 (66.43/17.73)	QGMPPGirmqgtpsvrvlgvqpgAGGA.........................................isGGVPVP.GQNV.LPGANDV.TSLQQQQAQAAQQGGQLML
  741-  812 (91.46/27.46)	QGCNTS.................TGRR...RAIP.NMVEQQPNAQQSV...........QQQQQL.....GNIPAPlSVNVgFNNANFVgVGEKQQLGSQSDQMAKLKL
  813-  866 (60.76/15.53)	QA..QS................................QAQVQAHVSV...........VSAGAP....gTGNSTA.GASV.LMPA.DT.TGVANSSSSGSNSSN..AG
  867-  923 (52.68/12.39)	AGSAGS.................AGGA...GGAPgSGSDSEKDWRESV.............TADL...rnHLVHKL.VQAI.FP.TSDP.TTMQDKR............
 2746- 2794 (40.00/ 7.46)	AGGAGG.................AGGAlqaGNGP.QTPQQQQQ.QQQVmqqqqmqhmmnQQQQ........G.PGP.G...............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.02|      11|      27|    1710|    1725|       7
---------------------------------------------------------------------------
 1710- 1725 (21.85/25.21)	YCCGRKYTFnpqvlC..C
 1740- 1752 (21.17/10.80)	YSYQNRYTF.....CqkC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.79|      29|     199|    1554|    1596|       8
---------------------------------------------------------------------------
 1496- 1524 (50.56/29.46)	NVNN..DGTS...MLKIDLKSE.......DGA..AGDVKIKSE
 1554- 1596 (30.23/50.94)	DINGaiDGVSagiASDIKIKSEtkpmvpePLApnAGDKKKKCQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.27|      19|      23|    2874|    2896|       9
---------------------------------------------------------------------------
 2874- 2896 (29.15/27.53)	GPhmgVAGqPQFPGGTTGNFNAG
 2899- 2917 (34.12/16.80)	GN...VTG.VQVAGTTVGSGAAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.50|      17|      23|     492|     513|      10
---------------------------------------------------------------------------
  492-  513 (25.15/19.00)	NYCKAmkavLAHMATCkQSKDC
  516-  536 (30.34/18.32)	QHCTSsrqiLLHYKTC.QRSDC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.54|      23|      23|    1776|    1798|      11
---------------------------------------------------------------------------
 1753- 1774 (19.88/ 8.46)	...FNDIQGDTVTLgdDPLQSQTQI
 1776- 1798 (40.98/27.29)	KDQFKEMKNDHLEL..EPFVDCQEC
 1802- 1823 (41.68/27.92)	QHQICVLWLDSIWP..GGFV.CDNC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     115.31|      26|      31|     341|     369|      17
---------------------------------------------------------------------------
  344-  369 (46.39/23.04)	SAGM...PQGNRPIGTV..VPMSSLGGDGPP
  372-  401 (39.18/11.26)	SGGLvgnPQQQQQLAAA.nAQMNPQQQQQPP
 1208- 1230 (29.74/ 7.74)	.......PQQLQQQSNAfnSPMQ.QKAQQPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.24|      20|      23|     925|     947|      19
---------------------------------------------------------------------------
  925-  947 (29.72/38.34)	HNLvsyAEK...VEKDMYEMAKSRSE
  950-  972 (27.51/22.91)	HLL...AEKiykIQKELEEKRLKRKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.89|      26|     198|    2057|    2082|      21
---------------------------------------------------------------------------
 2023- 2047 (21.10/10.91)	...IERIIQDykdiL..KQAMED..KLGSAAE
 2057- 2082 (40.61/28.93)	PNVLEESIKE....L..DQEEEEKRKQAEAAE
 2087- 2108 (17.18/ 7.29)	ANLFSAEDNE....VsgDGKKKGQKK......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.42|      15|      21|     979|     993|      22
---------------------------------------------------------------------------
  979-  993 (30.27/14.94)	LQMQQGGPNSGVVNP
 1001- 1015 (27.15/12.26)	LQQQPGQGVRPIISP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      99.81|      23|      60|     162|     184|      23
---------------------------------------------------------------------------
  162-  184 (40.50/17.31)	MVNSMPM.SISNNGNNGMNAIPGM
  186-  208 (24.18/ 6.97)	SIAQGNLgNMVLTNSGGMGTIGG.
  223-  245 (35.13/13.91)	LMNAVPG.SVGVSSVSGAAPSQGM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05537 with Med15 domain of Kingdom Metazoa
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